Abstract
The use of lipases as catalysts in organic synthesis was exemplified by the regiospecific preparation of 6-O-acyl ethyl glucosides using a lipase derived from Candida antarctica. Optimal reaction conditions were successfully predicted using an artificial neural network as computing tool. The fatty acyl glucosides were found to be efficient nonionic surface active materials usable in a wide range of applications. A novel lipase catalyzed synthesis of peroxycarboxylic acids and concomitant lipase mediated oxidation was investigated. Using this method, epoxides were generally obtained in high yields from the corresponding alkenes. Finally, the recent determination of the X-ray structure of a lipase inhibitor complex and studies of lipase inhibitor interactions provide novel insight into the mode of action and selectivity properties of lipases.
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© 1992 Springer Science+Business Media Dordrecht
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Björkling, F., Godtfredsen, S.E., Kirk, O., Patkar, S.A., Andresen, O. (1992). Lipase Catalyzed Organic Synthesis. In: Servi, S. (eds) Microbial Reagents in Organic Synthesis. NATO ASI Series, vol 381. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2444-7_20
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DOI: https://doi.org/10.1007/978-94-011-2444-7_20
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