Abstract
The stereospecificity of biomolecules is a characteristic feature of the molecular logic of living cells. Chiral natural products are usually present in only one of their possible chiral forms. Also, the configuration of molecules (natural or unnatural) is very important in their biological function. Asymmetric synthesis is a primary focus of activity in organic chemistry and enzymes offer a convenient alternative to conventional reagents as a means of expressing chirality in a synthetic scheme. We report here the chemoenzymatic synthesis (or approach) of natural products and bioactive compounds such as baclofen and fluoxetine (pharmaceuticals), amidinomycin and chloramphenicol (antibiotics), piperidine alkaloids, phospholipids and vitamin E.
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© 1992 Springer Science+Business Media Dordrecht
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Chênevert, R. et al. (1992). Chemoenzymatic Synthesis of Natural Products and Bioactive Compounds. In: Servi, S. (eds) Microbial Reagents in Organic Synthesis. NATO ASI Series, vol 381. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2444-7_11
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DOI: https://doi.org/10.1007/978-94-011-2444-7_11
Publisher Name: Springer, Dordrecht
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