Abstract
The role played by lactic acid bacteria in various biological functions of the host has been extensively reported. During the last two decades, numerous studies have demonstrated the anticarcinogenic properties of lactic acid bacteria and great emphasis has been laid on the antitumour activity exerted by yoghurt and by milks fermented with Lactobacillus acidophilus. Shahani et al. (1983) has demonstrated that, in mice fed with fermented colostrum, the growth of experimentally induced tumours was inhibited, but only in animals dosed before the onset of tumour growth. Reddy et al. (1983) and Ayebo et al. (1982) studied whether the antitumour effect was exerted by the presenee of lactic acid bacteria, by components of their cell wall, or by products formed as a consequence of the fermentation process. Ayebo et al. (1982) were able to isolate a dialysable antitumour component from yoghurt. Goldin and Gorbach (1980) demonstrated that in mice dosed with L. acidophilus there was a decrease in the incidence of the colon cancer induced by 1,2-dimethylhydrazine dihydrochloride. Kato et al. (1981, 1985) demonstrated that the intraperitoneal administration of L. casei inhibited tumour growth in both syngeneic and allogeneic mice. The effect depended on the dose and on the time of administration of L. casei; the antitumour activity was effective only in pre-treated animals.
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Perdigón, G., Alvarez, S. (1992). Probiotics and the immune state. In: Probiotics. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2364-8_7
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DOI: https://doi.org/10.1007/978-94-011-2364-8_7
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