Abstract
Vertebrates rely upon their livers for a multitude of functions (Arias et al., 1988; Zakim and Boyer, 1990). Notable examples include: the synthesis and secretion of plasma proteins and bile; the absorption, modification, storage and redistribution of nutrients absorbed from the diet by the gut; and the detoxification and elimination of potentially harmful xenobiotic compounds. These and many other crucial activities can be ascribed directly to the hepatocyte, the major epithelial cell of the liver. The remarkable ability of the hepatocyte to carry out this diverse group of processes derives in large part from its strategic positioning between blood plasma and bile and its attendant asymmetry. It is in this context that I will discuss selected aspects of what is presently known about the establishment and maintenance of hepatocyte surface polarity. By hepatocyte surface polarity I refer specifically to the compartmentalization of the hepatocyte surface (and plasma membrane) into structurally and functionally distinct domains which differ in molecular composition. Since relatively little is known about the compartmentalization of plasma membrane lipids by hepatocytes, this discussion will be, by necessity, focused upon the domain-specific plasma membrane proteins of hepatocytes.
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Bartles, J.R. (1992). The establishment and maintenance of hepatocyte surface polarity. In: Fleming, T.P. (eds) Epithelial Organization and Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2354-9_8
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