Skip to main content
SpringerLink
Log in

Trophectoderm biogenesis in the preimplantation mouse embryo

  • Chapter
Epithelial Organization and Development

Abstract

The trophectoderm epithelium is the first tissue to differentiate during mammalian development. It constitutes the wall of the spherical blastocyst and, after implantation, is the source of the major extra-embryonic lineages of the conceptus, notably trophoblastic giant cells, extra-embryonic ectoderm, ectoplacental cone and chorionic ectoderm (reviewed in Gardner, 1983; Gardner and Beddington, 1988). The trophectoderm differentiates gradually during cleavage of the fertilized egg. In the mouse, the process of epithelial biogenesis begins unambiguously at compaction in the 8-cell embryo when blastomeres become adhesive and flatten against each other, although certain biosynthetic events necessary for trophectoderm formation precede this stage. A functional epithelium is generated during the 32-cell stage, two cell cycles and about 24 hours after the embryo compacts. The newly-formed trophectoderm, with apical membranes facing outwards, engages in vectorial fluid transport to create the blastocoelic cavity. At the intervening cell divisions (8- to 16-cell stage and 16- to 32-cell stage), a proportion of prospective trophectoderm cells allocate one of their daughter cells to the embryo interior by differentiative cell division.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adler, R.R. and Ziomek, C.A. (1986) Cell specific loss of polarity-inducing ability by later stage mouse preimplantation embryos. Devl Biol., 114, 395–402.

    CAS  Google Scholar 

  • Adler, R.R. and Ziomek, C.A. (1989) Induction of murine 8-cell blastomere polarity by F9 embryonal carcinoma cells. Devl Biol., 135, 405–13.

    CAS  Google Scholar 

  • Allworth, A.E., Hildebrandt, J.D. and Ziomek, C.A. (1990) Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos. Devl Biol., 142, 129–37.

    CAS  Google Scholar 

  • Anderson, E. and Albertini, D.F. (1976) Gap junctions between the oocyte and companion follicle cells in the mammalian ovary. J. Cell Biol., 71, 680–6.

    PubMed  CAS  Google Scholar 

  • Anderson, J.M., Stevenson, B.R., Jesaitis, L.A., Goodenough, D.A. and Mooseker, M.S. (1988) Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin — Darby canine kidney cells. J. Cell Biol., 106, 1141–9.

    PubMed  CAS  Google Scholar 

  • Bevilacqua, A., Loch-Caruso, R. and Erickson, R.P. (1989) Abnormal development and dye coupling produced by antisense RNA to gap junction protein in mouse preimplantation embryos. Proc. Natn. Acad. Sci. USA, 86, 5444–8.

    CAS  Google Scholar 

  • Blaschuk, O.W., Sullivan, R., David, S. and Pouliot, Y. (1990) Identification of a cadherin cell adhesion recognition sequence. Devl Biol., 139, 227–9.

    CAS  Google Scholar 

  • Bloom, T.L. (1989) The effects of phorbol ester on mouse blastomeres: a role for protein kinase C in compaction? Development, 106, 159–71.

    PubMed  CAS  Google Scholar 

  • Bloom, T.L. (1991) Experimental manipulation of compaction of the mouse embryo alters patterns of protein phosphorylation. Molec. Reprod. Devel., 28, 230–44.

    CAS  Google Scholar 

  • Bloom, T.L. and McConnell, J. (1990) Changes in protein phosphorylation associated with compaction of the mouse preimplantation embryo. Molec. Reprod. Devel., 26, 199–210.

    CAS  Google Scholar 

  • Braude, P.R. (1979) Time-dependent effects of α-amanitin on blastocyst formation in the mouse. J. Embryol. Exp. Morph., 52, 193–202.

    PubMed  CAS  Google Scholar 

  • Chisholm J.C. and Houliston, E. (1987) Cytokeratin filament assembly in the preimplantation mouse embryo. Development, 101, 565–82.

    PubMed  CAS  Google Scholar 

  • Citi, S., Sabanay, H., Jakes, R., Geiger, B. and Kendrick-Jones, J. (1988) Cingulin, a new peripheral component of tight junctions. Nature, 333, 272–6.

    PubMed  CAS  Google Scholar 

  • Cooper, A.R. and MacQueen, H.A. (1983) Subunits of laminin are differentially synthesised in mouse eggs and early embryos. Devl Biol,, 96, 467–71.

    CAS  Google Scholar 

  • Cunningham, B.A., Leutzinger, Y., Gallin, W.J., Sorkin, B.C. and Edelman, G.M. (1984) Linear organization of the liver cell adhesion molecule L-CAM. Proc. Natn. Acad. Sci. USA., 81, 5787–91.

    CAS  Google Scholar 

  • Dardik, A. and Schultz, R.M. (1991) Protein secretion by the mouse blastocyst: differences in the polypeptide composition secreted into the blastocoel and medium. Biol. Reprod., 45, 328–33.

    PubMed  CAS  Google Scholar 

  • Dean, W.L. and Rossant, J. (1984) Effect of delaying DNA replication on blastocyst formation in the mouse. Differentiation, 26, 134–7.

    PubMed  CAS  Google Scholar 

  • DiZio, S.M. and Tasca, R.J. (1977) Sodium-dependent amino acid transport in preimplantation mouse embryos. III. Na+-K+-ATPase linked mechanism in blastocysts. Devl Biol., 59, 198–205.

    CAS  Google Scholar 

  • Ducibella, T. and Anderson, E. (1975) Cell shape and membrane changes in the 8-cell mouse embryo: prerequisites for morphogenesis of the blastocyst. Devl Biol., 47, 45–58.

    CAS  Google Scholar 

  • Ducibella, T., Albertini, D.F., Anderson, E. and Biggers, J.D. (1975) The preimplantation mammalian embryo: characterization of intercellular junctions and their appearance during development. Devl Biol., 45, 231–50.

    CAS  Google Scholar 

  • Ducibella, T., Ukena, T., Karnovsky, M. and Anderson, E. (1977) Changes in cell surface and cortical cytoplasmic organization during early embryogenesis in the preimplantation mouse embryo. J. Cell Biol., 74, 153–67.

    PubMed  CAS  Google Scholar 

  • Dziadek, M. and Timpl, R. (1985) Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells. Devl Bio., 111, 372–82.

    CAS  Google Scholar 

  • Emerson, J.A. (1988) Disruption of the cytokeratin filament network in the preimplantation mouse embryo. Development, 104, 219–34.

    PubMed  CAS  Google Scholar 

  • Evsikov, S.V., Morozova, L.M. and Solomko, A.P. (1990) The role of the nucleocytoplasmic ratio in development regulation of the early mouse embryo. Development, 109, 323–8.

    PubMed  CAS  Google Scholar 

  • Fenderson, B.A., Eddy, E.M. and Hakomori, S. (1990) Glycoconjugate expression during embryogenesis and its biological significance. BioEssays, 12, 173–9.

    PubMed  CAS  Google Scholar 

  • Flach, G., Johnson, M.H., Braude, P.R., Taylor, R. and Bolton, V.N. (1982) The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J., 1, 681–6.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P. (1987) A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst. Devl Biol., 119, 520–31.

    CAS  Google Scholar 

  • Fleming, T.P. (1990) Cell differentiation in the mouse preimplantation embryo, in Mechanism of Fertilization: plants to humans (ed. B. Dale), NATO ASI Series, Vol. H45, Springer-Verlag, Berlin, pp. 679–97.

    Google Scholar 

  • Fleming, T.P. and Goodall, H. (1986) Endocytic traffic in trophectoderm and polarised blastomeres of the mouse preimplantation embryo. Anat. Rec., 216, 490–503.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P. and Hay, M.J. (1991) Tissue-specific control of expression of the tight junction polypeptide ZO-1 in the mouse early embryo. Development, 113, 295–304.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P. and Johnson, M.H. (1988) From egg to epithelium. A. Rev. Cell Biol., 4, 459–485.

    CAS  Google Scholar 

  • Fleming, T.P. and Pickering, S.J. (1985) Maturation and polarisation of the endocytotic system in outside blastomeres during mouse preimplantation development. J. Embryol Exp. Morph., 89, 175–208.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P., Cannon, P.M. and Pickering, S.J. (1986a) The cytoskeleton, endocytosis and cell polarity in the mouse preimplantation embryo. Devl Biol., 113, 406–19.

    CAS  Google Scholar 

  • Fleming, T.P., Garrod, D.R. and Elsmore, A.J. (1991) Desmosome biogenesis in the mouse preimplantation embryo. Development, 112, 527–39.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P., McConnell, J., Johnson, M.H. and Stevenson, B.R. (1989) Development of tight junctions de novo in the mouse early embryo: control of assembly of the tight junction-specific protein, ZO-1. J. Cell Biol., 108, 1407–18.

    PubMed  CAS  Google Scholar 

  • Fleming, T.P., Pickering, S.J., Qasim, F. and Maro, B. (1986b) The generation of cell surface polarity in mouse 8-cell blastomeres: the role of cortical microfilaments analysed using cytochalasin D. J. Embryol. Exp. Morph., 95, 169–91.

    PubMed  CAS  Google Scholar 

  • Gardiner, C.S., Williams, J.S. and Menino, A.R. (1990) Sodium/potassium adenosine triphosphatase α- and β-subunit and α-subunit mRNA levels during mouse embryo development in vitro. Biol. Reprod., 43, 788–94.

    PubMed  CAS  Google Scholar 

  • Gardner, R.L. (1983) Origin and differentiation of extraembryonic tissues in the mouse. Int. Rev. Exp. Path., 24, 63–133.

    PubMed  CAS  Google Scholar 

  • Gardner, R.L. and Beddington, R.S.P. (1988) Multi-lineage ‘stem’ cells in the mammalian embryo. J. Cell Sci., 10 (Suppl.), 11–27.

    CAS  Google Scholar 

  • Gilula, N.B., Epstein, M.L. and Beers, W.H. (1978) Cell-to-cell communication and ovulation: a study of the cumulus — oocyte complex. J. Cell Biol., 78, 58–75.

    PubMed  CAS  Google Scholar 

  • Goodall, H. (1986) Manipulation of gap junctional communication during compaction of the mouse early embryo. J. Embryol Exp. Morph., 91, 283–96.

    PubMed  CAS  Google Scholar 

  • Goodall, H. and Johnson, M.H. (1984) The nature of intercellular coupling within the preimplantation mouse embryo. J. Embryol. Exp. Morph., 79, 53–76.

    PubMed  CAS  Google Scholar 

  • Handyside, A.H. (1980) Distribution of antibody- and lectin-binding sites on dissociated blastomeres of mouse morulae: evidence for polarisation at compaction. J. Embryol. Exp. Morph., 60, 99–116.

    PubMed  CAS  Google Scholar 

  • Handyside, A.H., Edinin, M. and Wolf, D.E. (1987) Polarized distribution of membrane components on two-cell mouse embryos. Roux’s Arch. Devl Biol., 196, 273–8.

    Google Scholar 

  • Harvey, M.C. and Kaye, P.L. (1990) Insulin increases the number of the inner cell mass and stimulates morphological development of mouse blastocysts in vitro. Development, 110, 963–7.

    PubMed  CAS  Google Scholar 

  • Heyner, S., Smith, R.M. and Schultz, G.A. (1989) Temporally regulated expression of insulin and insulin-like growth factors and their receptors in early mammalian development. BioEssays, 11, 171–6.

    PubMed  CAS  Google Scholar 

  • Houliston, E. and Maro, B. (1989) Posttranslational modification of distinct microtubule subpopulations during cell polarization and differentiation in the mouse preimplantation embryo. J. Cell Biol., 108, 543–51.

    PubMed  CAS  Google Scholar 

  • Houliston, E., Pickering, S.J. and Maro, B. (1987) Redistribution of microtubules and pericentriolar material during the development of polarity in mouse blastomeres. J. Cell Biol., 104, 1299–308.

    PubMed  CAS  Google Scholar 

  • Houliston, E., Pickering, S.J. and Maro, B. (1989) Alternative routes for the establishment of surface polarity during compaction of the mouse embryo. Devl Biol., 134, 342–50.

    CAS  Google Scholar 

  • Hyafil, F., Morello, D., Babinet, C. and Jacob, F. (1980) A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Cell, 21, 927–34.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H. and Maro, B. (1984) The distribution of cytoplasmic actin in mouse 8-cell blastomeres. J. Embryol. Exp. Morph., 82, 97–117.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H. and Maro, B. (1985) A dissection of the mechanisms generating and stabilising polarity in mouse 8- and 16-cell blastomeres: the role of cytoskeletal elements. J. Embryol Exp. Morph., 90, 311–34.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H. and Maro, B. (1986) Time and space in the mouse early embryo: a cell biological approach to cell diversification. In: Experimental Approaches to Mammalian Embryonic Development (eds J. Rossant and R.A. Pedersen), Cambridge University Press, New York, pp. 35–66.

    Google Scholar 

  • Johnson, M.H. and Ziomek, C.A. (1981a) Induction of polarity in mouse 8-cell blastomeres: specificity, geometry and stability. J. Cell Biol., 91, 303–8.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H. and Ziomek, C.A. (1981b) The foundation of two distinct cell lineages within the mouse morula. Cell, 24, 71–80.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H., Chisholm, J.C, Fleming, T.P. and Houliston, E. (1986a) A role for cytoplasmic determinants in the development of the mouse early embryo? J. Embryol. Exp. Morph., 97 (Suppl.), 97–121.

    PubMed  Google Scholar 

  • Johnson, M.H., Maro, B. and Takeichi, M. (1986b) The role of cell adhesion in the synchronisation and orientation of polarisation in 8-cell mouse blastomeres. J. Embryol. Exp. Morph., 93, 239–55.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H., Pickering, S.J., Dhiman, A., Radcliffe, G.S. and Maro, B. (1988) Cytocortical organisation during natural and prolonged mitosis in mouse 8-cell blastomeres. Development, 102, 143–58.

    PubMed  CAS  Google Scholar 

  • Jones, J. and Schultz, R.M. (1990) Pertussis toxin-catalyzed ADP-ribosylation of a G protein in mouse oocytes, eggs, and preimplantation embryos: developmental changes and possible functional roles. Devl Biol., 139, 250–62.

    CAS  Google Scholar 

  • Kaye, P.L., Schultz, G.A., Johnson, M.H., Pratt, H.P. and Church, R.B. (1982) Amino acid transport and exchange in preimplantation mouse embryos. J. Reprod. Fertil., 65, 367–80.

    PubMed  CAS  Google Scholar 

  • Kemler, R., Gossler, A., Mansouri, A. and Vestweber, D. (1990) The cell adhesion molecule uvomorulin, in Morphoregulatory Molecules (eds G.M. Edelman, B.A. Cunningham and J.-P. Thiery), Neurosciences Institute Publication, Wiley, Chichester, pp. 41–56.

    Google Scholar 

  • Kidder, G.M. and McLachlin, J.R. (1985) Timing of transcription and protein synthesis underlying morphogenesis in preimplantation mouse embryos. Devl Biol., 112, 265–75.

    CAS  Google Scholar 

  • Kidder, G.M. and Watson, A.J. (1990) Gene expression required for blastocoel formation in the mouse, in Early Embryo Development and Paracrine Relationships (UCLA Symposia on Molecular and Cellular Biology, New Series Vol. 117) (eds S. Heyner and L.M. Wiley), Alan R. Liss, New York, pp. 97–107.

    Google Scholar 

  • Kimber, S.J. (1990) Glycoconjugates and cell surface interactions in pre- and peri-implantation mammalian embryonic development. Int. Rev. Cytol., 120, 53–167.

    PubMed  CAS  Google Scholar 

  • Latham, K.E., Garrels, J.I., Chang, C and Solter, D. (1991) Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages. Development, 112, 921–32.

    PubMed  CAS  Google Scholar 

  • Lee, S., Gilula, N.B. and Warner, A.E. (1987) Gap junctional communication and compaction during preimplantation stages of mouse development. Cell, 51, 851–60.

    PubMed  CAS  Google Scholar 

  • Lehtonen, E. and Reima, I. (1986) Changes in the distribution of vinculin during preimplantation mouse development. Differentiation, 32, 125–34.

    PubMed  CAS  Google Scholar 

  • Lehtonen, E., Ordonez, G. and Reima, I. (1988) Cytoskeleton in preimplantation mouse development. Cell Differentiation, 24, 165–78.

    PubMed  CAS  Google Scholar 

  • Leivo, I., Vaheri, A., Timpl, R. and Wartiovaara, J. (1980) Appearance and distribution of collagens and laminin in the early mouse embryo. Devl Biol., 76, 100–14.

    CAS  Google Scholar 

  • Levy, J.B., Johnson, M.H., Goodall, H. and Maro, B. (1986) Control of the timing of compaction: a major developmental transition in mouse early development. J. Embryol. Exp. Morph., 95, 213–37.

    PubMed  CAS  Google Scholar 

  • Lo, C.W. and Gilula, N.B. (1979) Gap junctional communication in the preimplantation mouse embryo. Cell, 18, 399–409.

    PubMed  CAS  Google Scholar 

  • Magnuson, T., Demsey, A. and Stackpole, C.W. (1977) Characterization of intercellular junctions in the preimplantation mouse embryo by freeze-fracture and thin-section electron microscopy. Devl Biol., 61, 252–61.

    CAS  Google Scholar 

  • Manejwala, F.M. and Schultz, R.M. (1989) Blastocoel expansion in the preimplantation mouse embryo: stimulation of sodium uptake by cAMP and possible involvement of cAMP-dependent protein kinase. Devl Biol., 136, 560–3.

    CAS  Google Scholar 

  • Manejwala, F.M., Cragoe, E.J. and Schultz, R.M. (1989) Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. Devl Biol., 133, 210–20.

    CAS  Google Scholar 

  • Manejwala, F.M., Kali, E. and Schultz, R.M. (1986) Development of activatable adenylate cyclase in the preimplantation mouse embryo and a role for cyclic AMP in blastocoel formation. Cell, 46, 95–103.

    PubMed  CAS  Google Scholar 

  • Maro, B., Houliston, E. and de Pennart, H. (1988) Microtubule dynamics and cell diversification in the mouse preimplantation embryo. Protoplasma, 145, 160–6.

    Google Scholar 

  • Maro, B., Johnson, M.H., Pickering, S.J. and Flach, G. (1984) Changes in actin distribution during fertilization of the mouse egg. J. Embryol. Exp. Morph., 81, 211–37.

    PubMed  CAS  Google Scholar 

  • Maro, B., Johnson, M.H., Pickering, S.J. and Louvard, D. (1985) Changes in the distribution of membraneous organelles during mouse early development. J. Embryol. Exp. Morph., 90, 287–309.

    PubMed  CAS  Google Scholar 

  • McLachlin, J.R. and Kidder, G.M. (1986) Intercellular junctional coupling invpreimplantation mouse embryos: effect of blocking transcription or translation. Devl Biol., 117, 146–55.

    CAS  Google Scholar 

  • McLachlin, J.R., Caveney, S. and Kidder, G.M. (1983) Control of gap junction formation in early mouse embryos. Devl Biol., 98, 155–64.

    CAS  Google Scholar 

  • Merz, E.A., Brinster, R.L., Brunner, S. and Chen, H.Y. (1981) Protein degradation during preimplantation development of the mouse. J. Reprod. Fertil., 61, 415–18.

    PubMed  CAS  Google Scholar 

  • Mulnard, J.G. and Huygens, R. (1978) Ultrastructural localization of nonspecific alkaline phosphatase during cleavage and blastocyst formation in the mouse. J. Embryol. Exp. Morph., 44, 121–31.

    PubMed  CAS  Google Scholar 

  • Nishi, M., Kumar, N.M. and Gilula, N.B. (1991) Developmental regulation of gap junction gene expression during mouse embryonic development. Devl Biol., 146, 117–30.

    CAS  Google Scholar 

  • Nuccitelli, R. and Wiley, L. (1985) Polarity of isolated blastomeres from mouse morulae: detection of transcellular ion currents. Devl Biol., 109, 452–63.

    CAS  Google Scholar 

  • O’Shea, K.S., Liu, L.-H.J., Kinnunen, L.H. and Dixit, V.M. (1990) Role of extracellular matrix protein thrombospondin in the early development of the mouse embryo. J. Cell Biol., 111, 2713–23.

    Google Scholar 

  • Ozawa, M., Ringwald, M. and Kemler, R. (1990) Uvomorulin — catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Natn. Acad. Sci. U.S.A., 87, 4246–50.

    CAS  Google Scholar 

  • Pemble, L.B. and Kaye, P.L. (1986) Whole protein uptake and metabolism by mouse blastocysts. J. Reprod. Pert., 78, 149–57.

    CAS  Google Scholar 

  • Peyrieras, N., Hyafil, F., Louvard, D., Ploegh, H.L. and Jacob, F. (1983) Uvomorulin: a non-integral membrane protein of early mouse embryo. Proc. Natn. Acad. Sci. U.S.A., 80, 6274–7.

    CAS  Google Scholar 

  • Pickering, S.J., Maro, B., Johnson, M.H. and Skepper, J.N. (1988) The influence of cell contact on the division of mouse 8-cell blastomeres. Development, 103, 353–63.

    PubMed  CAS  Google Scholar 

  • Pierce, K.E. and Calarco, P.G. (1990) Establishment and maintenance of a regionalized glycoprotein distribution during early mouse development. Devl Biol., 137, 56–67.

    CAS  Google Scholar 

  • Pinto-Correia, C., Goldstein, E.G., Bennett, V. and Sobel, J.S. (1991) Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Devl Biol., 146, 301–11.

    CAS  Google Scholar 

  • Prather, R.S. and First, N.L. (1986) Reprogramming of murine blastocoele formation. J. Exp. Zool., 237, 347–50.

    PubMed  CAS  Google Scholar 

  • Pratt, H.P.M. (1985) Membrane organization in the preimplantation mouse embryo. J. Embryol. Exp. Morph., 90, 101–21.

    PubMed  CAS  Google Scholar 

  • Pratt, H.P.M. (1989) Marking time and making space: chronology and topography in the early mouse embryo. Int. Rev. Cytol., 117, 99–130.

    PubMed  CAS  Google Scholar 

  • Reeve, W.J.D. (1981a) Cytoplasmic polarity develops at compaction in rat and mouse embryos. J. Embryol. Exp. Morph., 62, 351–67.

    PubMed  CAS  Google Scholar 

  • Reeve, W.J.D. (1981b) The distribution of ingested horseradish peroxidase in the 16-cell mouse embryo. J. Embryol. Exp. Morph., 66, 191–207.

    PubMed  CAS  Google Scholar 

  • Reeve, W.J.D. and Ziomek, C.A. (1981) Distribution of microvilli on dissociated blastomeres from mouse embryos: evidence for surface polarization at compaction. J. Embryol. Exp. Morph., 62, 339–50.

    PubMed  CAS  Google Scholar 

  • Ringwald, M., Schuh, R., Vestweber, D. et al. (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J., 6, 3647–53.

    PubMed  CAS  Google Scholar 

  • Schatten, H., Cheney, R., Balczon, R. et al. (1986) Localisation of fodrin during fertilization and early development of sea urchin and mice. Devl Biol., 118, 457–66.

    CAS  Google Scholar 

  • Schultz, G.A. (1986) Molecular biology of the early mouse embryo. Biol. Bull., 171, 291–309.

    CAS  Google Scholar 

  • Sepulveda, S. and Izquierdo, L. (1990) Effect of cell contact on regionalization of mouse embryos. Devl Biol., 139, 363–9.

    CAS  Google Scholar 

  • Shirayoshi, Y., Okada, T.S. and Takeichi, M. (1983) The calcium-dependent cell — cell adhesion system regulates inner cell mass formation and cell surface polarization in early mouse development. Cell, 35, 631–8.

    PubMed  CAS  Google Scholar 

  • Smith, R.K.W. and Johnson, M.H. (1985) DNA replication and compaction in the cleaving embryo of the mouse. J. Embryol. Exp. Morph., 89, 133–48.

    PubMed  CAS  Google Scholar 

  • Smith, R. and McLaren, A. (1977) Factors affecting the time of formation of the mouse blastocoel. J. Embryol. Exp. Morph., 41, 79–92.

    PubMed  CAS  Google Scholar 

  • Sobel, J.S. (1983) Cell — cell contact modulation of myosin organisation in the early mouse embryo. Devl Biol., 100, 207–13.

    CAS  Google Scholar 

  • Sobel, J.S. and Alliegro, M.A. (1985) Changes in the distribution of a spectrin-like protein during development of the preimplantation mouse embryo. J. Cell Biol., 100, 333–6.

    PubMed  CAS  Google Scholar 

  • Stevenson, B.R., Siliciano, J.D., Mooseker, M.S. and Goodenough, D.A. (1986) Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol., 103, 755–66.

    PubMed  CAS  Google Scholar 

  • Surani, M.A.H. and Barton, S.C. (1984) Spatial distribution of blastomeres is dependent on cell division order and interactions in mouse morulae. Devl Biol., 102, 335–43.

    CAS  Google Scholar 

  • Surani, M.A.H., Barton, S.C. and Burling, A. (1980) Differentiation of 2-cell and 8-cell mouse embryos arrested by cytoskeletal inhibitors. Expl Cell Res., 125, 275–86.

    CAS  Google Scholar 

  • Surani, M.A.H., Kimber, S.J. and Handyside, A.H. (1981) Synthesis and role of cell surface glycoproteins in preimplantation mouse development. Expl Cell Res., 133, 331–9.

    CAS  Google Scholar 

  • Sutherland, A.E. and Calarco-Gillam, P.G. (1983) Analysis of compaction in the preimplantation mouse embryo. Devl Biol., 100, 328–38.

    CAS  Google Scholar 

  • Van Winkle, L.J. and Campione, A.L. (1991) Ouabain-sensitive Rb+ uptake in mouse eggs and preimplantation conceptuses. Devl Biol., 146, 158–66.

    Google Scholar 

  • Vestweber, D., Gossler, A., Boller, K. and Kemler, R. (1987) Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos. Devl Biol., 124, 451–6.

    CAS  Google Scholar 

  • Vorbrodt, A., Konwinski, M., Solter, D. and Koprowski, H. (1977) Ultra-structural cytochemistry of membrane-bound phosphatases in preimplantation mouse embryos. Devl Biol., 55, 117–34.

    CAS  Google Scholar 

  • Wartiovaara, J., Leivo, I. and Vaheri, A. (1979) Expression of the cell surface-associated glycoprotein, fibronectin, in the early mouse embryo. Devl Biol., 69, 247–57.

    CAS  Google Scholar 

  • Watson, A.J. and Kidder, C.M. (1988) Immunofluorescence assessment of the timing of appearance and cellular distribution of Na/K-ATPase during mouse embryogenesis. Devl Biol., 126, 80–90.

    CAS  Google Scholar 

  • Watson, A.J., Damsky, C.H. and Kidder, G.M. (1990a) Differentiation of an epithelium: factors affecting the polarized distribution of Na+, K+-ATPase in mouse trophectoderm. Devl Biol., 141, 104–14.

    CAS  Google Scholar 

  • Watson, A.J., Pape, C, Emanuel, J.R., Levenson, R. and Kidder, G.M. (1990b) Expression of Na, K-ATPase α and ß subunit genes during preimplantation development of the mouse. Devl Genet., 11, 41–8.

    CAS  Google Scholar 

  • Wiley, L.M. (1987) Trophectoderm: the first epithelium to develop in the mammalian embryo. Scanning Microsc., 2, 417–26.

    Google Scholar 

  • Wiley, L.M. and Obasaju, M.F. (1988) Induction of cytoplasmic polarity in heterokaryons of mouse 4-cell-stage blastomeres fused with 8-cell- and 16-cell-stage blastomeres. Devl Biol., 130, 276–84.

    CAS  Google Scholar 

  • Wiley, L.M. and Obasaju, M.F. (1989) Effects of phlorizin and ouabain on the polarity of mouse 4-cell/16-cell stage blastomere heterokaryons. Devl Biol., 133, 375–84.

    CAS  Google Scholar 

  • Wiley, L.M., Kidder, G.M. and Watson, A.J. (1990) Cell polarity and development of the first epithelium. BioEssays, 12, 67–73.

    PubMed  CAS  Google Scholar 

  • Wiley, L.M., Lever, J.E., Pape, C. and Kidder, G.M. (1991) Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Devl Biol., 143, 149–61.

    CAS  Google Scholar 

  • Winkel, G.K., Ferguson, J.E., Takeichi, M. and Nuccitelli, R. (1990) Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo. Devl Biol., 138, 1–15.

    CAS  Google Scholar 

  • Ziomek, C.A. (1987) Cell polarity in the preimplantation mouse embryo, in The Mammalian Preimplantation Embryo (ed. B.D. Bavister), Plenum Press, New York, pp. 23–42.

    Google Scholar 

  • Ziomek, C.A. and Johnson, M.H. (1980) Cell surface interactions induce polarisation of mouse 8-cell blastomeres at compaction. Cell, 21, 935–42.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, University of Southampton, UK

    Tom P. Fleming

Authors
  1. Tom P. Fleming
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO9 3TU, UK

    Tom P. Fleming

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Fleming, T.P. (1992). Trophectoderm biogenesis in the preimplantation mouse embryo. In: Fleming, T.P. (eds) Epithelial Organization and Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2354-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-2354-9_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5040-1

  • Online ISBN: 978-94-011-2354-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation