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Epithelial Organization and Development pp 1–52Cite as

Intercellular junctions and cell adhesion in epithelial cells

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Abstract

The intercellular junctions of epithelial cells are of four types (Figures 1.1 and 1.2). There are two types of adhesive or adherens junctions, firstly desmosomes or maculae adherentes, and secondly the so-called intermediate junctions, often zonular in structure, the zonulae adherentes. Tight junctions are also generally zonular in structure and are called zonulae occludentes to denote their function of occluding the paracellular epithelial channels. Gap junctions, like desmosomes, are punctate structures that provide low resistance channels between cells for the purpose of metabolic co-operation and intercellular communication. Since tight and gap junctions are dependent upon intercellular binding between their structural components, they also contribute to intercellular adhesion as well as performing their specialized functions. In addition to these intercellular junctions, cell adhesion receives a contribution from non-junction adhesion molecules which are present on parts of the cell membrane having no apparent ultrastructural specialization. Our purpose is to review the current state of knowledge of these intercellular junctions and non-junctional adhesion mechanisms with specific reference to epithelial cells.

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    David R. Garrod & Jane E. Collins

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    Tom P. Fleming

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Garrod, D.R., Collins, J.E. (1992). Intercellular junctions and cell adhesion in epithelial cells. In: Fleming, T.P. (eds) Epithelial Organization and Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2354-9_1

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