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Chirospecific synthesis of amino acids and analogues

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Book cover Amino Acids

Abstract

Proline and its analogues demonstrate a wide range of biological activity, inview of that we have synthesized amino acid analogues having pyrrolidine ring starting from Af-carbamoylpyroglutamate (1). In this process we have established regio-selective mono-addition reaction, stereospecific substitution at C-4 and pyrrolidine ring formation.

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Tohoku University, Aobayama, Sendai, 980, Japan

    Tomihisa Ohta, Akio Hosoi, Toshihiko Kimura, Nobuaki Sato & Shigeo Nozoe

  2. Basic Research Department, Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, 210, Japan

    Kunisuke Izawa

Authors
  1. Tomihisa Ohta
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  2. Akio Hosoi
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  3. Toshihiko Kimura
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  4. Nobuaki Sato
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  5. Kunisuke Izawa
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  6. Shigeo Nozoe
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Vienna, A-1090, Vienna, Austria

    Gert Lubec

  2. T. H. Morgan School of Biological Sciences and The Graduate Center for Toxicology, University of Kentucky, 40506-0225, Lexington, Kentucky, USA

    Gerald A. Rosenthal

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© 1990 ESCOM Science Publishers B.V.

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Ohta, T., Hosoi, A., Kimura, T., Sato, N., Izawa, K., Nozoe, S. (1990). Chirospecific synthesis of amino acids and analogues. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_2

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  • DOI: https://doi.org/10.1007/978-94-011-2262-7_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-72199-04-1

  • Online ISBN: 978-94-011-2262-7

  • eBook Packages: Springer Book Archive

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