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Histiocytic disorders

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Paediatric Neoplasia

Part of the book series: Current Histopathology ((CUHI,volume 22))

Abstract

This is a complex group of reactive and neoplasmic disorders that originate generally from at least two different subsets of immune accessory cell: (a) the dendritic cell system (DCS) and (b) the mononuclear phagocyte system (MPS) 1-3. Immunohistochemistry and electron microscopy are often important in their differentiation4.

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References

  1. Favara B.E., McCarthy R.C., Mierau G.W. Histiocytosis X. Hum Pathol. 1983:14;663–76.

    Article  PubMed  CAS  Google Scholar 

  2. Nezelof C, Barbey S. Histiocytosis: nosology and pathobiology. Pediatr Pathol. 1985:3:1–41.

    Article  PubMed  CAS  Google Scholar 

  3. Headington J.T., Cerio R. Dendritic cells and the dermis. Am J Dermatopathol. 1990:12:217–220.

    Google Scholar 

  4. The Writing Group of the Histiocyte Society. Histiocytosis syndromes in children. Lancet. 1987:1:208–9.

    Google Scholar 

  5. Goldberg J, Nezelof C. Lymphohistiocytosis: a multi-factorial syndrome of macrophage activation. Clinicopathological study of 38 cases. Hematol Oncol. 1986;4:275–89.

    Article  PubMed  CAS  Google Scholar 

  6. Maennle D.L., Grierson H.L., Gnarra D.G., Weisenburger D.D. Sinus histiocytosis with massive lymphadenopathy: a spectrum of disease and dysfunction. Pediatr Pathol. 1991;11:399–412.

    Article  PubMed  CAS  Google Scholar 

  7. Lichtenstein L. Histiocytosis X. Integration of eosinophilic granuloma of bone, ‘Letterer-Siwe disease’, and’ schuller-Christian disease’ as related manifestations of a single nosologic entity. Arch Pathol. 1953;56:84–102.

    CAS  Google Scholar 

  8. Jaffe R. Pathology of histiocytosis X. Perspect Pediatr Pathol. 1987;9:4–47.

    PubMed  CAS  Google Scholar 

  9. Nezelof C. Histiocytosis X: histological and histogenetic study. Perspect Pediatr Pathol. 1979;5:153–78.

    PubMed  CAS  Google Scholar 

  10. Steinman R.M. Dendritic cells. Transplantation. 1981;31:151–5.

    Article  PubMed  CAS  Google Scholar 

  11. Webster S.M., Beabout J.W., Unni K.K., Dahlin D.C. Langerhans’ cell granulomatosis (histiocytosis X) of bone in adults. Am J Surg Pathol. 1982;6:413–26.

    Article  Google Scholar 

  12. Basset F, Nezelof C, Ferrans V.J. The histiocytoses. Pathol Annu. 1983;18:27–78.

    PubMed  Google Scholar 

  13. McCullough C.J. Eosinophilic granuloma of bone. Acta Orthop Scand. 1980;51:389–98.

    Article  PubMed  CAS  Google Scholar 

  14. McCaffrey T.V., McDonald T.J. Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope. 1979;89:1735–42.

    Article  PubMed  CAS  Google Scholar 

  15. Motoi M, Helbron D, Kaiserling E, Lennert K. Eosinophilic granuloma of lymph nodes-a variant of histiocytosis X. Histopathology. 1980;4:585–606.

    Article  PubMed  CAS  Google Scholar 

  16. Kjeldsberg C.R., Kim H. Eosinophilic granuloma as an incidental finding in malignant lymphoma. Arch Pathol Lab Med. 1980;104:137–40.

    PubMed  CAS  Google Scholar 

  17. Reid H, Fox H, Whittaker J.S. Eosinophilic granuloma of lymph nodes. Histopathology. 1977;1:31–7.

    Article  PubMed  CAS  Google Scholar 

  18. Leblanc A. Hadchouel M, Jehan P, Odievre M, Alagille D. Obstructive jaundice in children with histiocytosis X. Gastroenterology. 1981;80:134–9.

    PubMed  CAS  Google Scholar 

  19. Egeler R.M., Schipper M.E.I., Heymans H.S.A. Eur J Pediatr. 1980;149:325–9.

    Article  Google Scholar 

  20. Dehner L.P. Gastrointestinal tract. In: Dehner L.P. editor. Pediatric surgical pathology, 2nd edn. Baltimore: Williams & Wilkins; 1987:360.

    Google Scholar 

  21. Tamura T. Umetsu M, Motoya H, Yokoyama S. Congenital Letterer-Siwe disease associated with protein losing enteropathy. Eur J Pediatr. 1980;135;77–80.

    Article  PubMed  CAS  Google Scholar 

  22. Risdall R.J., Dehner L.P., Duray P, Kobrinsky N, Robison L, Nesbit M.E. Histiocytosis X (Langerhans’ cell histiocytosis). Arch Pathol Lab Med. 1983;107:59–63.

    PubMed  CAS  Google Scholar 

  23. Alexis J.B., Poppiti R.J., Turbat-Herrera E, Smith M.D. Congenital self-healing reticulohistiocytosis. Report of a case with 7-year follow-up and review of the literature. Am J Dermatopathol. 1991;13:189–94.

    Article  PubMed  CAS  Google Scholar 

  24. Dehner L.P., Bamford J.T., McDonald E.C. Spontaneous regression of congenital cutaneous histiocytosis X: Report of a case with discussion of nosology and pathogenesis. Pediatr Pathol. 1983;1:99–106.

    Article  PubMed  CAS  Google Scholar 

  25. Kanitakis J, Zambruno G, Schmitt D, Cambazard F, Jacquemier D, Thivolet J. Congenital self-healing histiocytosis (Hashimoto-Pritzker). An ultrastructural and immunohistochemical study. Cancer. 1988;61:508–16.

    Article  PubMed  CAS  Google Scholar 

  26. Tahan R.T., Pastel-Levy C, Bhan A.K., Mihn M.C. Juvenile xanthothogranuloma. Clinical and pathologic characterization. Arch Pathol Lab Med. 1989;113:1057–61.

    PubMed  CAS  Google Scholar 

  27. Sonoda T, Hashimoto H, Enjoji M. Juvenile xanthogranuloma. Clinicopathologic analysis and immunohistochemical study of 57 patients. Cancer. 1985;56:2280–6.

    Article  PubMed  CAS  Google Scholar 

  28. Seo S, Whan Min K, Mirkin D. Juvenile xanthogranuloma. Arch Pathol Lab Med. 1986;110:911–15.

    PubMed  CAS  Google Scholar 

  29. Janney C.G., Hurt M.A. Santa Cruz D.J. Deep juvenile xanthogranuloma. Subcutaneous and intramuscular forms. Am J Surg Pathol. 1991;15:150–9.

    Article  PubMed  CAS  Google Scholar 

  30. White W, Garen P. Juvenile xanthogranuloma of the paravertebral soft tissue in infancy: a report of two cases. Pediatr Pathol. 1991;11:105–13.

    Article  PubMed  CAS  Google Scholar 

  31. Gianotti F, Caputo R, Ermacora E, Gianni E. Benign cephalic histiocytosis. Arch Dermatol. 1986;122:1038–43.

    Article  PubMed  CAS  Google Scholar 

  32. Barsky B.L., Lao I. Barsky S, Rhee H.L. Benign cephalic histiocytosis. Arch Dermatol. 1984;120:650–5.

    Article  PubMed  CAS  Google Scholar 

  33. Farquhar J.W., Claireaux A.E. Familial haemophagocytic reticulosis. Arch Dis Child. 1952;27:519–25.

    Article  PubMed  CAS  Google Scholar 

  34. Henter J.I. Elinder G, Ost A and the FHL Study Group of the Histiocyte Society. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. Semin Oncol. 1991;18:29–33.

    PubMed  CAS  Google Scholar 

  35. Spritz R.A. The familial histiocytoses. Pediatr Pathol. 1985;3:43–57.

    Article  PubMed  CAS  Google Scholar 

  36. Janka G.E. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr. 1983;140:221–30.

    Article  PubMed  CAS  Google Scholar 

  37. Henter J.I., Elinder G. Cerebromeningeal haemophagocytic lymphohistiocytosis. Lancet. 1992;339:104–7.

    Article  PubMed  CAS  Google Scholar 

  38. Gilbert E.F., ZuRhein G.M., Webster S.M. et al. Familial hemophagocytic lymphohistiocytosis: report of four cases in two families and review of the literature. Pediatr Pathol. 1985;3:59–92.

    Article  PubMed  CAS  Google Scholar 

  39. Wieczorek R, Greco M.A. McCarthy K, Bonetti F, Knowles D.M. Familial erythrophagocytic lymphohistiocytosis: immunophenotypic, immunohistochemical. and ultrastructural demonstration of the relation to sinus histiocytes. Hum Pathol. 1986;17:55–63.

    Article  PubMed  CAS  Google Scholar 

  40. Risdall R.J., McKenna R.W., Nesbit M.E., Krivit W, Balfour H.H., Simmons R.L., Brunning R.D. Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979;44:993–1002.

    Article  PubMed  CAS  Google Scholar 

  41. McKenna R.W., Risdall R.J., Brunning R.D.. Virus associated hemophagocytic syndrome. Hum Pathol. 1981;12:395–8.

    Article  PubMed  CAS  Google Scholar 

  42. Arya S, Hong R, Gilbert E.F. Reactive haemophagocytic syndrome. Pediatr Pathol. 1985;3:129–41.

    Article  PubMed  CAS  Google Scholar 

  43. Mroczek E.C., Weisenburger D.D., Lipscomb Grierson H, Markin R, Purtilo D.T. Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. Arch Pathol Lab Med. 1987;111:530–5.

    PubMed  CAS  Google Scholar 

  44. Chen R.L., Su I.J., Lin K.H. Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. Am J Clin Pathol. 1991;96:171–6.

    PubMed  CAS  Google Scholar 

  45. McClain K, Gehrz R, Grierson H, Purtillo D, Filipovich A. Virus-associated histiocytic proliferations in children. Am J Ped Hemat/Oncol. 1988;10:196–205.

    Article  CAS  Google Scholar 

  46. Goldberg J, Nezelof C. Lymphohistiocytosis: a multi-factorial syndrome of macrophagic activation. Clinico-pathological study of 38 cases. Hematol Oncol. 1986;4:275–89.

    Article  PubMed  CAS  Google Scholar 

  47. Buckley P.J., O’Laughlin S, Komp D.M. Histiocytes in familial and infection-induced/idiopathic hemophagocytic syndromes may exhibit phenotypic differences. Pediatr Pathol. 1992;12:51–66.

    Article  PubMed  CAS  Google Scholar 

  48. Rosai J, Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87:63–70.

    PubMed  CAS  Google Scholar 

  49. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagnost Pathol. 1990;7:19–73.

    CAS  Google Scholar 

  50. Foucar E, Rosai J, Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy. Ear, nose and throat manifestations. Arch Otolaryngol. 1978;104:687–93.

    Article  PubMed  CAS  Google Scholar 

  51. Buchino J.J., Byrd R.P., Kmetz D.R. Disseminated sinus histiocytosis with massive lymphadenopathy. Its pathological aspects. Arch Pathol Lab Med. 1982;106:13–16.

    PubMed  CAS  Google Scholar 

  52. Zucker J.M., Caillaux J.M., Vanel D, Gerard-Marchant R. Malignant histiocytosis in childhood. Clinical study and therapeutic results in 22 cases. Cancer. 1980;45:2821–9.

    Article  PubMed  CAS  Google Scholar 

  53. Jurco S, Starling K, Hawkins E. Malignant histiocytosis in childhood: morphological considerations. Hum Pathol. 1983;14:1059–65.

    Article  PubMed  Google Scholar 

  54. Chan J.K.C., Ng C.S., Hui P.K., et al. Anaplastic large cell Ki-1 lymphoma. Delineation of two types. Histopathology. 1989;15:11–34.

    Article  PubMed  CAS  Google Scholar 

  55. Ishii E, Hara T, Okumura J, et al. Malignant histiocytosis in infants: surface marker analysis of malignant cells in two cases. Med Ped Oncol. 1987;15:102–8.

    Article  CAS  Google Scholar 

  56. Weiss L.M., Trela M.J., Cleary M.L. Turner R.R., Warnke R.A. Sklar J. Frequent immunoglobulin and T-cell receptor gene rearrangements in ‘histiocytic’ neoplasms. Am J Pathol. 1985;121:369–73.

    PubMed  CAS  Google Scholar 

  57. Flynn K.J., Dehner L.P., Gajl-Peczalska K.J., Dahl M.V., Ramsay N, Wang N. Regressing atypical histiocytosis: a cutaneous proliferation of a typical neoplastic histiocytes with unexpectedly indolent biological behaviour. Cancer. 1982;49:959–70.

    Article  PubMed  CAS  Google Scholar 

  58. Dehner L.P. Case 5. Ki-1 lymphoma. Pediatr Pathol. 1991;11:183–90.

    Article  PubMed  CAS  Google Scholar 

  59. Rosner F, Grunwald H.W. Association of T cell acute lymphoblastic leukaemia and histiocytic medullary reticulosis. Am J Med. 1984;77:910–14.

    Article  PubMed  CAS  Google Scholar 

  60. Chen T.K., Nesbit M.E., McKenna R, Kersey J.H. Histiocytic medullary reticulosis in acute lymphocytic leukaemia of T cell origin. Am J Dis Child. 1976;130:1262–4.

    PubMed  CAS  Google Scholar 

  61. Yin Liu J.A. Kumaran T.O., Marsh G.W., Rossiter M, Catovksy D. Complete recovery of histiocytic medullary reticulosis-like syndrome in a child with acute lymphoblastic leukemia. Cancer. 1983;51:200–2.

    Article  Google Scholar 

  62. Jaffe E.S., Costa J, Fauci A.S., Cossman J, Tsokos M. Malignant lymphoma and erythrophagocytosis simulating malignant histioocytosis. Am J Med. 1983;75:741–9.

    Article  PubMed  CAS  Google Scholar 

  63. Chan E.Y.T., Pi D, Chan G.T.C., Todd D, Ho F.C.S. Peripheral T-cell lymphoma presenting as hemophagocytic syndrome. Hematol Oncol. 1989;7;275–85.

    Article  PubMed  CAS  Google Scholar 

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© 1993 S. Variend

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Variend, S. (1993). Histiocytic disorders. In: Paediatric Neoplasia. Current Histopathology, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2224-5_9

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  • DOI: https://doi.org/10.1007/978-94-011-2224-5_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4986-3

  • Online ISBN: 978-94-011-2224-5

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