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Histiocytic disorders

Chapter
Part of the Current Histopathology book series (CUHI, volume 22)

Abstract

This is a complex group of reactive and neoplasmic disorders that originate generally from at least two different subsets of immune accessory cell: (a) the dendritic cell system (DCS) and (b) the mononuclear phagocyte system (MPS) 1-3. Immunohistochemistry and electron microscopy are often important in their differentiation4.

Keywords

Eosinophilic Granuloma Sinus Histiocytosis Birbeck Granule Malignant Histiocytosis Urticaria Pigmentosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Favara B.E., McCarthy R.C., Mierau G.W. Histiocytosis X. Hum Pathol. 1983:14;663–76.PubMedCrossRefGoogle Scholar
  2. 2.
    Nezelof C, Barbey S. Histiocytosis: nosology and pathobiology. Pediatr Pathol. 1985:3:1–41.PubMedCrossRefGoogle Scholar
  3. 3.
    Headington J.T., Cerio R. Dendritic cells and the dermis. Am J Dermatopathol. 1990:12:217–220.Google Scholar
  4. 4.
    The Writing Group of the Histiocyte Society. Histiocytosis syndromes in children. Lancet. 1987:1:208–9.Google Scholar
  5. 5.
    Goldberg J, Nezelof C. Lymphohistiocytosis: a multi-factorial syndrome of macrophage activation. Clinicopathological study of 38 cases. Hematol Oncol. 1986;4:275–89.PubMedCrossRefGoogle Scholar
  6. 6.
    Maennle D.L., Grierson H.L., Gnarra D.G., Weisenburger D.D. Sinus histiocytosis with massive lymphadenopathy: a spectrum of disease and dysfunction. Pediatr Pathol. 1991;11:399–412.PubMedCrossRefGoogle Scholar
  7. 7.
    Lichtenstein L. Histiocytosis X. Integration of eosinophilic granuloma of bone, ‘Letterer-Siwe disease’, and’ schuller-Christian disease’ as related manifestations of a single nosologic entity. Arch Pathol. 1953;56:84–102.Google Scholar
  8. 8.
    Jaffe R. Pathology of histiocytosis X. Perspect Pediatr Pathol. 1987;9:4–47.PubMedGoogle Scholar
  9. 9.
    Nezelof C. Histiocytosis X: histological and histogenetic study. Perspect Pediatr Pathol. 1979;5:153–78.PubMedGoogle Scholar
  10. 10.
    Steinman R.M. Dendritic cells. Transplantation. 1981;31:151–5.PubMedCrossRefGoogle Scholar
  11. 11.
    Webster S.M., Beabout J.W., Unni K.K., Dahlin D.C. Langerhans’ cell granulomatosis (histiocytosis X) of bone in adults. Am J Surg Pathol. 1982;6:413–26.CrossRefGoogle Scholar
  12. 12.
    Basset F, Nezelof C, Ferrans V.J. The histiocytoses. Pathol Annu. 1983;18:27–78.PubMedGoogle Scholar
  13. 13.
    McCullough C.J. Eosinophilic granuloma of bone. Acta Orthop Scand. 1980;51:389–98.PubMedCrossRefGoogle Scholar
  14. 14.
    McCaffrey T.V., McDonald T.J. Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope. 1979;89:1735–42.PubMedCrossRefGoogle Scholar
  15. 15.
    Motoi M, Helbron D, Kaiserling E, Lennert K. Eosinophilic granuloma of lymph nodes-a variant of histiocytosis X. Histopathology. 1980;4:585–606.PubMedCrossRefGoogle Scholar
  16. 16.
    Kjeldsberg C.R., Kim H. Eosinophilic granuloma as an incidental finding in malignant lymphoma. Arch Pathol Lab Med. 1980;104:137–40.PubMedGoogle Scholar
  17. 17.
    Reid H, Fox H, Whittaker J.S. Eosinophilic granuloma of lymph nodes. Histopathology. 1977;1:31–7.PubMedCrossRefGoogle Scholar
  18. 18.
    Leblanc A. Hadchouel M, Jehan P, Odievre M, Alagille D. Obstructive jaundice in children with histiocytosis X. Gastroenterology. 1981;80:134–9.PubMedGoogle Scholar
  19. 19.
    Egeler R.M., Schipper M.E.I., Heymans H.S.A. Eur J Pediatr. 1980;149:325–9.CrossRefGoogle Scholar
  20. 20.
    Dehner L.P. Gastrointestinal tract. In: Dehner L.P. editor. Pediatric surgical pathology, 2nd edn. Baltimore: Williams & Wilkins; 1987:360.Google Scholar
  21. 21.
    Tamura T. Umetsu M, Motoya H, Yokoyama S. Congenital Letterer-Siwe disease associated with protein losing enteropathy. Eur J Pediatr. 1980;135;77–80.PubMedCrossRefGoogle Scholar
  22. 22.
    Risdall R.J., Dehner L.P., Duray P, Kobrinsky N, Robison L, Nesbit M.E. Histiocytosis X (Langerhans’ cell histiocytosis). Arch Pathol Lab Med. 1983;107:59–63.PubMedGoogle Scholar
  23. 23.
    Alexis J.B., Poppiti R.J., Turbat-Herrera E, Smith M.D. Congenital self-healing reticulohistiocytosis. Report of a case with 7-year follow-up and review of the literature. Am J Dermatopathol. 1991;13:189–94.PubMedCrossRefGoogle Scholar
  24. 24.
    Dehner L.P., Bamford J.T., McDonald E.C. Spontaneous regression of congenital cutaneous histiocytosis X: Report of a case with discussion of nosology and pathogenesis. Pediatr Pathol. 1983;1:99–106.PubMedCrossRefGoogle Scholar
  25. 25.
    Kanitakis J, Zambruno G, Schmitt D, Cambazard F, Jacquemier D, Thivolet J. Congenital self-healing histiocytosis (Hashimoto-Pritzker). An ultrastructural and immunohistochemical study. Cancer. 1988;61:508–16.PubMedCrossRefGoogle Scholar
  26. 26.
    Tahan R.T., Pastel-Levy C, Bhan A.K., Mihn M.C. Juvenile xanthothogranuloma. Clinical and pathologic characterization. Arch Pathol Lab Med. 1989;113:1057–61.PubMedGoogle Scholar
  27. 27.
    Sonoda T, Hashimoto H, Enjoji M. Juvenile xanthogranuloma. Clinicopathologic analysis and immunohistochemical study of 57 patients. Cancer. 1985;56:2280–6.PubMedCrossRefGoogle Scholar
  28. 28.
    Seo S, Whan Min K, Mirkin D. Juvenile xanthogranuloma. Arch Pathol Lab Med. 1986;110:911–15.PubMedGoogle Scholar
  29. 29.
    Janney C.G., Hurt M.A. Santa Cruz D.J. Deep juvenile xanthogranuloma. Subcutaneous and intramuscular forms. Am J Surg Pathol. 1991;15:150–9.PubMedCrossRefGoogle Scholar
  30. 30.
    White W, Garen P. Juvenile xanthogranuloma of the paravertebral soft tissue in infancy: a report of two cases. Pediatr Pathol. 1991;11:105–13.PubMedCrossRefGoogle Scholar
  31. 31.
    Gianotti F, Caputo R, Ermacora E, Gianni E. Benign cephalic histiocytosis. Arch Dermatol. 1986;122:1038–43.PubMedCrossRefGoogle Scholar
  32. 32.
    Barsky B.L., Lao I. Barsky S, Rhee H.L. Benign cephalic histiocytosis. Arch Dermatol. 1984;120:650–5.PubMedCrossRefGoogle Scholar
  33. 33.
    Farquhar J.W., Claireaux A.E. Familial haemophagocytic reticulosis. Arch Dis Child. 1952;27:519–25.PubMedCrossRefGoogle Scholar
  34. 34.
    Henter J.I. Elinder G, Ost A and the FHL Study Group of the Histiocyte Society. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. Semin Oncol. 1991;18:29–33.PubMedGoogle Scholar
  35. 35.
    Spritz R.A. The familial histiocytoses. Pediatr Pathol. 1985;3:43–57.PubMedCrossRefGoogle Scholar
  36. 36.
    Janka G.E. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr. 1983;140:221–30.PubMedCrossRefGoogle Scholar
  37. 37.
    Henter J.I., Elinder G. Cerebromeningeal haemophagocytic lymphohistiocytosis. Lancet. 1992;339:104–7.PubMedCrossRefGoogle Scholar
  38. 38.
    Gilbert E.F., ZuRhein G.M., Webster S.M. et al. Familial hemophagocytic lymphohistiocytosis: report of four cases in two families and review of the literature. Pediatr Pathol. 1985;3:59–92.PubMedCrossRefGoogle Scholar
  39. 39.
    Wieczorek R, Greco M.A. McCarthy K, Bonetti F, Knowles D.M. Familial erythrophagocytic lymphohistiocytosis: immunophenotypic, immunohistochemical. and ultrastructural demonstration of the relation to sinus histiocytes. Hum Pathol. 1986;17:55–63.PubMedCrossRefGoogle Scholar
  40. 40.
    Risdall R.J., McKenna R.W., Nesbit M.E., Krivit W, Balfour H.H., Simmons R.L., Brunning R.D. Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979;44:993–1002.PubMedCrossRefGoogle Scholar
  41. 41.
    McKenna R.W., Risdall R.J., Brunning R.D.. Virus associated hemophagocytic syndrome. Hum Pathol. 1981;12:395–8.PubMedCrossRefGoogle Scholar
  42. 42.
    Arya S, Hong R, Gilbert E.F. Reactive haemophagocytic syndrome. Pediatr Pathol. 1985;3:129–41.PubMedCrossRefGoogle Scholar
  43. 43.
    Mroczek E.C., Weisenburger D.D., Lipscomb Grierson H, Markin R, Purtilo D.T. Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. Arch Pathol Lab Med. 1987;111:530–5.PubMedGoogle Scholar
  44. 44.
    Chen R.L., Su I.J., Lin K.H. Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. Am J Clin Pathol. 1991;96:171–6.PubMedGoogle Scholar
  45. 45.
    McClain K, Gehrz R, Grierson H, Purtillo D, Filipovich A. Virus-associated histiocytic proliferations in children. Am J Ped Hemat/Oncol. 1988;10:196–205.CrossRefGoogle Scholar
  46. 46.
    Goldberg J, Nezelof C. Lymphohistiocytosis: a multi-factorial syndrome of macrophagic activation. Clinico-pathological study of 38 cases. Hematol Oncol. 1986;4:275–89.PubMedCrossRefGoogle Scholar
  47. 47.
    Buckley P.J., O’Laughlin S, Komp D.M. Histiocytes in familial and infection-induced/idiopathic hemophagocytic syndromes may exhibit phenotypic differences. Pediatr Pathol. 1992;12:51–66.PubMedCrossRefGoogle Scholar
  48. 48.
    Rosai J, Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87:63–70.PubMedGoogle Scholar
  49. 49.
    Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagnost Pathol. 1990;7:19–73.Google Scholar
  50. 50.
    Foucar E, Rosai J, Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy. Ear, nose and throat manifestations. Arch Otolaryngol. 1978;104:687–93.PubMedCrossRefGoogle Scholar
  51. 51.
    Buchino J.J., Byrd R.P., Kmetz D.R. Disseminated sinus histiocytosis with massive lymphadenopathy. Its pathological aspects. Arch Pathol Lab Med. 1982;106:13–16.PubMedGoogle Scholar
  52. 52.
    Zucker J.M., Caillaux J.M., Vanel D, Gerard-Marchant R. Malignant histiocytosis in childhood. Clinical study and therapeutic results in 22 cases. Cancer. 1980;45:2821–9.PubMedCrossRefGoogle Scholar
  53. 53.
    Jurco S, Starling K, Hawkins E. Malignant histiocytosis in childhood: morphological considerations. Hum Pathol. 1983;14:1059–65.PubMedCrossRefGoogle Scholar
  54. 54.
    Chan J.K.C., Ng C.S., Hui P.K., et al. Anaplastic large cell Ki-1 lymphoma. Delineation of two types. Histopathology. 1989;15:11–34.PubMedCrossRefGoogle Scholar
  55. 55.
    Ishii E, Hara T, Okumura J, et al. Malignant histiocytosis in infants: surface marker analysis of malignant cells in two cases. Med Ped Oncol. 1987;15:102–8.CrossRefGoogle Scholar
  56. 56.
    Weiss L.M., Trela M.J., Cleary M.L. Turner R.R., Warnke R.A. Sklar J. Frequent immunoglobulin and T-cell receptor gene rearrangements in ‘histiocytic’ neoplasms. Am J Pathol. 1985;121:369–73.PubMedGoogle Scholar
  57. 57.
    Flynn K.J., Dehner L.P., Gajl-Peczalska K.J., Dahl M.V., Ramsay N, Wang N. Regressing atypical histiocytosis: a cutaneous proliferation of a typical neoplastic histiocytes with unexpectedly indolent biological behaviour. Cancer. 1982;49:959–70.PubMedCrossRefGoogle Scholar
  58. 58.
    Dehner L.P. Case 5. Ki-1 lymphoma. Pediatr Pathol. 1991;11:183–90.PubMedCrossRefGoogle Scholar
  59. 59.
    Rosner F, Grunwald H.W. Association of T cell acute lymphoblastic leukaemia and histiocytic medullary reticulosis. Am J Med. 1984;77:910–14.PubMedCrossRefGoogle Scholar
  60. 60.
    Chen T.K., Nesbit M.E., McKenna R, Kersey J.H. Histiocytic medullary reticulosis in acute lymphocytic leukaemia of T cell origin. Am J Dis Child. 1976;130:1262–4.PubMedGoogle Scholar
  61. 61.
    Yin Liu J.A. Kumaran T.O., Marsh G.W., Rossiter M, Catovksy D. Complete recovery of histiocytic medullary reticulosis-like syndrome in a child with acute lymphoblastic leukemia. Cancer. 1983;51:200–2.CrossRefGoogle Scholar
  62. 62.
    Jaffe E.S., Costa J, Fauci A.S., Cossman J, Tsokos M. Malignant lymphoma and erythrophagocytosis simulating malignant histioocytosis. Am J Med. 1983;75:741–9.PubMedCrossRefGoogle Scholar
  63. 63.
    Chan E.Y.T., Pi D, Chan G.T.C., Todd D, Ho F.C.S. Peripheral T-cell lymphoma presenting as hemophagocytic syndrome. Hematol Oncol. 1989;7;275–85.PubMedCrossRefGoogle Scholar

Copyright information

© S. Variend 1993

Authors and Affiliations

  1. 1.Department of HistopathologySheffield Children’s HospitalSheffieldUK

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