Abstract
In 1921, James Ewing1 described a primary malignant tumour of bone in which he emphasized the perivascular arrangement of the tumour cells. A wide age range is affected but the neoplasm predominates in the second decade. It is the second most common malignant tumour of bone in children. The most common affected sites are the pelvis and femur and there is a modest male predominance. Babies and toddlers are affected in 2% of cases2.The most frequent symptoms are pain and swelling.
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References
Ewing J. Diffuse endothelioma of the bone. Proc New York Pathol Soc. 1921;21:17–18.
Siegal G.P., Schoppe J., Foulkes M., Kissane J.M., Askin F.B. Ewing’s sarcoma in babies and toddlers; a clinicopathological report from the Intergroup Ewing’s Sarcoma Study Group (Abstract). Lab Invest. 1983;48:13P.
Kissane J.M., Askin F.B., Foulkes M, Stratton L.B., Shirley S.F. Ewing’s sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing’s Sarcoma Study. Hum Pathol. 1983;14:773–9.
Kissane J.M., Askin F.B., Nesbit M.E. Jr et al. Sarcomas of the bone in childhood: pathologic aspects. Cancer Inst Monogr. 1981;56:29–41.
Lichtenstein L, Jaffe H.L. Ewing’s sarcoma of bone. Am J Pathol. 1947;23:43–77.
Dahlin D.C., Coventry M.B., Scanlon P.W. Ewing’s sarcoma: a critical analysis of 165 cases. J Bone Jt Surg. 1961;43A:185–92.
Povysil C, Matejovsky A. Ultrastructure of Ewing’s tumour. Virchows Arch (pathol Anat). 1977;374:303–16.
Mahoney J.P., Alexander R.W. Ewing’s sarcoma. A light-and electron-microscopic study of 21 cases. Am J Surg Pathol. 1978;2:283–98.
Jaffe R, Santamaria M, Yunis E.J. et al. The neuroectodermal tumor of bone. Am J Surg Pathol. 1984;8:885–98.
Hartman K.R., Triche T.J., Kinsella T.J., Miser J.S. Prognostic value of histopathology in Ewing’s sarcoma. Cancer. 1991;67:163–71.
Aurias A. Rimbaut C., Buffe D., Dubousset J, Mazabraud A. Chromosomal translocations in Ewing’s sarcoma. N Engl J Med. 1983;309:496–7.
Turc-Carel C, Philip I. Berger M.P., Philip T. Lenoir G.M. Chromosomal translocation in Ewing’s sarcoma. N Engl J Med. 1983;309:497–8.
Nance C.L., Roberts W.M., Miller G.R. Ewing’s sarcoma mimicking osteomyelitis. South Med J. 1967;60:1044–50.
Cabanela M.E., Franklin H.S., Beabout J.W., Dahlin D.C. Osteomyelitis appearing as neoplasms: a diagnostic problem. Arch Surg. 1974;109;68–72.
Sim F.H., Unni K.K., Beabout J.W., Dahlin D.C. Osteosarcoma with small cells simulating Ewing’s tumour. J Bone Jt Surg. 1979;61A:207–15.
Salvador A.H., Beabout J.W., Dahlin D.C. Mesenchymal chondrosarcoma-observation in 30 new cases. Cancer. 1971;28:605–15.
Jacobson S.A. Polyhistiocytoma: a malignant tumor of bone and extraskeletal tissue. Cancer. 1977;40:2116–30.
Ayala A.G., Ro J.Y., Raymond A.K. et al. Small cell osteosarcoma: a clinicopathologic study of 27 cases. Cancer. 1989;64:2162–73.
Churg A. Ringus J. Ultrastructural observations on the histogenesis of alveolar rhabdomyosarcoma. Cancer. 1978;41:1355–61.
Kadin M.E., Bensch K.G. On the origin of Ewing’s tumor. Cancer.1971;27;257–73.
Schmidt D, Mackay B, Ayala A.G. Ewing’s sarcoma with neuroblastoma-like features. Ultrastruct Pathol. 1982;3:143–51.
Moll R, Lee I, Gould V.E. et al. Immunohistochemical analysis of Ewing’s tumors. Am J Pathol. 1987;127:288–304.
Ambros I.M., Ambros P.F., Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors. Cancer. 1991;67:1886–93.
Angervall L, Enzinger F.M. Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer. 1975;36:240–51.
Soule E.H., Newton W Jr, Moon T.E., Tefft M. Extraskeletal Ewing’s sarcoma. Cancer. 1978;42:259–64.
Rud N.P., Reiman H.M., Pritchard D.J., Frassica F.J., Smithson W.A. Extraosseous Ewing’s sarcoma. Cancer. 1989;64:1548–53.
Tefft M, Vawter G.F., Mitus S, Paravertebral ‘round-cell’ tumours in children. Radiology. 1969;92:1501–9.
Miettinen M, Lehto V.P., Virtanen I. Histogenesis of Ewing’s sarcoma. An evaluation of intermediate filaments and endothelial cell markers. Virchows Arch (pathol Anat). 1982;41:277–84.
Carter R.L. Al-Sam S.Z., Corbett R.P., Clinton S. A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing’s sarcoma and other round cell tumours in children. Histopathology. 1990;16:461–7.
Ushigome S., Shimoda T, Takaki K et al. Immunocytochemical and ultrastructural studies of the histogenesis of Ewing’s sarcoma and putatively related tumors. Cancer. 1989;64:52–62.
Donner L, Triche T.J., Israel M.A. Seeger R.C., Reynolds C.P. A panel of monoclonal antibodies which discriminate neuroblastoma from Ewing’s sarcoma, rhabdomyosarcoma, neuroepithelioma, and hemapoietic malignancies. Prog Clin Biol Res. 1985;175:347–66.
Lipinski M, Braham K, Philip I et al. Neuroectoderm-associated antigens on Ewing’s sarcoma cell lines. Cancer Res. 1987;47:183–7.
Liombart-Bosch A Blanche R, Peydro-Olaya A. Ultrastructural study of 28 cases of Ewing’s sarcoma: typical and atypical forms. Cancer. 1978;41;1362–73.
Hou-Jensen K, Priori E, Dmochowski L. Studies on ultrastructure of Ewing’s sarcoma of bone. Cancer. 1972;29:280–6.
Dickman P.S., Triche T.J. Extraosseous Ewing’s sarcoma versus primitive rhabdomyosarcoma. Diagnostic criteria and clinical correlation. Hum Pathol. 1986;17:881–93.
Cavazzana A.O., Miser J.S., Jefferson J, Triche T.J. Experimental evidence for a neural origin of Ewing’s sarcoma of bone. Am J Pathol. 1987;127:507–18.
Wigger H.J., Salazar G.H., Blanc W.A. Extraskeletal Ewing’s sarcoma. An ultrastructural study. Arch Pathol Lab Med. 1977;101:446–9.
Meister P, Gokel J.M. Extraskeletal Ewing’s sarcoma. Virchows Arch (pathol Anat). 1978;378:173–9.
Navas-Palacios J.J., Aparicio-Duque R., Valdes M.D. On the histogenesis of Ewing’s sarcoma. An ultrastructural immunohistochemical and cytochemical study. Cancer. 1984;53:1882–901.
Nascimento A.G., Unni K.K., Pritchard D.J., Cooper K.L., Dahlin D.C. A clinicopathological study of 20 cases of large-cell (atypical) Ewing’s sarcoma of bone. Am J Clin Pathol. 1980;4:29–36.
Liombart-Bosch A Blanche R, Peydro-Olaya A. Round cell sarcomas of bone and their differential diagnosis (with particular emphasis on Ewing’s sarcoma and reticulosarcoma). Hum Pathol. 1982;17:113–45.
Phillips R.F., Higginbotham N.L. The curability of Ewing’s endothelioma of bone in children. J Pediatr. 1967;70:391–7.
Stratton B, Askin F.B., Kissane J.M. Intramyofiber skeletal muscle invasion in Ewing’s sarcoma of the bone: clinicopathological observations from the Intergroup Ewing’s Sarcoma Study. Am J Pediatr Hematol Oncol. 1982;4:231–5.
McKeon C, Thiele C.J., Ross R.A. et al. Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing’s sarcoma and neuroepithelioma. Cancer Res. 1988;48:4307–11.
Shimada H, Newton W.A. Soule E.H., Qualman S.J., Aoyama C, Maurer H.M. Pathologic features of extraosseous Ewing’s sarcoma. A report from the Intergroup Rhabdomyosarcoma Study. Hum Pathol. 1988;19:442–53.
Whang-Peng J, Triche T.J., Knuten T, Miser J, Douglass E.C., Israel M.A. Chromosome translocation in peripheral neuroepithelioma. N Engl J Med. 1984;311:584–5.
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© 1993 S. Variend
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Variend, S. (1993). Ewing’s sarcoma. In: Paediatric Neoplasia. Current Histopathology, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2224-5_8
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DOI: https://doi.org/10.1007/978-94-011-2224-5_8
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