Wilms’ tumour and the nephroblastoma complex
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Nephroblastoma is the most common renal neoplasm of childhood1. Of all childhood malignancies it has the highest probability of long-term survival with an overall cure rate of approximately 90%2. It is universally accepted as a malignant embryonal neoplasm arising from the primitive blastema of the kidney. In the National Wilms’ Tumor Study (NWTS) in the USA the mean age at diagnosis for sporadic unilateral cases was 45 months, with 80% of cases diagnosed in the first 5 years of life. The random risk for developing Wilms’ tumour has been estimated to be 1 in 10000 births. At diagnosis, 6% of tumours are bilateral2; patients with bilateral tumours tend to present at a younger age3. Congenital Wilms’ tumours have been reported on rare occasions4.
KeywordsUterine Fibroid Cystic Nephroma Mesoblastic Nephroma Multilocular Cyst Congenital Mesoblastic Nephroma
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