Abstract
The recognition that impairment of mucosal defence might play a part in the pathogenesis of peptic ulcération predates the identification of H. pylori by more than 70 years. In 1910 Schwarz hypothesized that peptic ulcer is a product of self digestion, which results from a ‘disproportion in the normal balance between the autopeptic power of gastric juice and the protective forces of the gastric mucous membrane’. Since this time various abnormalities of mucosal defence have been identified in peptic ulceration, but their importance in pathogenesis has remained unclear (Fig. 1).
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References
Quigley EM, Turnberg LA. pH of the microclimate lining human gastric and duodenal mucosa in vivo. Studies in control subjects and in duodenal ulcer patients. Gastroenterology. 1987;92:1876–1884.
Talley NJ, Ormand JE, Frie CA et al. Stability of pH gradients in vivo across the stomach in Helicobater pylori gastritis, dyspepsia, and health. Am J Gastroenterol. 1992;87:590–594.
Kelly SM, Crampton JR, Hunter JO. Helicobacter pylori increases gastric antral juxtamucosal pH. Dig Dis Sci. 1993;38:129–131.
Allen A, Cunliffe WJ, Pearson JP et al. The adherent gastric mucus gel barrier in man and changes in peptic ulceration. J Intern Med. 1990;228(Suppl l):83–90.
Sarosiek J, Marshall BJ, Peura DA et al. Gastroduodenal mucus gel thickness in patients with Helicobacter pylori: a method for assessment of biopsy specimens. Am J Gastroenterol. 1991;86:729–734.
Younan F, Pearson JP, Allen A et al. Changes in the structure of mucus gel on the mucosal surface of the stomach in association with peptic ulcer disease. Gastroenterology. 1982;82:827–831.
Sellers LA, Allen A, Morris ER et al. Mechanical characterization and properties of gastrointestinal mucus gel. Biorheology. 1987;24:615–623.
Kazi JL, Sinniah R, Zaman V et al. Ultrastructural study of Helicobacter pylori-associated gastritis. J Pathol. 1990;161:65–70.
Baczako K, Melzner I, Malfertheiner P et al. In vitro glycoprotein synthesis and secretion by gastric mucosal tissue of patients with gastritis. Am J Gastroenterol. 1986;81:346–353.
Liau YH, Lopez RA, Slomiany A et al. Helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of gastric sulfomucin. Biochem. Biophys Res Commun. 1992;184:1411–1417.
Slomiany BL, Bilski J, Sarosiek J et al. Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Biochem Biophys Res Commun. 1987;144:307–314.
Baxter A, Campbell CJ, Cox DM et al. Proteolytic activities of human Campylobacter pylori and ferret gastric Campylobacter-like organism. Biochem Biophys Res Commun. 1989; 163:1–7.
Sidebotham RL, Batten JJ, Karim QN et al. Breakdown of gastric mucus in presence of Helicobacter pylori. J Clin Pathol. 1991;44:52–57.
Murty VL, Sarosiek J, Slomiany A et al. Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein. Biochem Biophys Res Commun. 1984;121:521–529.
Slomiany BL, Kasinathan C, Slomiany A. Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-No1). Am J Gastroenterol. 1989;84:1273–1277.
Slomiany BL, Piotrowski J, Slomiany A. Effect of sucralfate on the degradation of human gastric mucus by Helicobacter pylori protease and lipases. Am J Gastroenterol. 1992;87: 595–599.
Langton SR, Cesareo SD. Helicobacter pylori associated phospholipase A2 activity: a factor in peptic ulcer production? J Clin Pathol. 1992;45:221–224.
Wassef MK, Lin YN, Horowitz MI. Phospholipid-deacylating enzymes of rat stomach mucosa. Biochim Biophys Acta. 1978;528:318–330.
Martin GP, Marriot C, Kellaway IW. Direct effect of bile salts and phospholipids on the physical properties of mucus. Gut. 1978;19:103–107.
Hills BA, Butler BD, Lichtenberger LM. Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol. 1983;244:G561–568.
Lichtenberger LM, Richards JE, Hills BA. Effect of 16,16-dimethyl Prostaglandin E2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. Gastroenterology. 1985;88:308–314.
Spychal RT, Marrero JM, Saverymuttu SH et al. Measurement of surface hydrophobicity of human gastrointestinal mucosa. Gastroenterology. 1989;97:104–111.
Spychal RT, Goggin PG, Marrero JM et al. Surface hydrophobicity of gastric mucosa in peptic ulcer disease: relationship to gastritis and Campylobacter pylori infection. Gastroenterology. 1990;98:1250–1254.
Goggin PM, Marrero JM, Spychal RT et al. Surface hydrophobicity of gastric mucosa in Helicobacter pylori infection: effect of clearance and eradication. Gastroenterology. 1992;103:1486–1490.
Johnson REJ, Dettre RH. Wettability and contact angles. Surf Colloid Sci. 1969;2:85–153.
Adamson AW. Physical chemistry of surfaces, 4th edn. New York: Wiley, 1982.
Slomiany BL, Nishikawa H, Piotrowski J et al. Lipolytic activity of Campylobacter pylori: effect of sofalcone. Digestion. 1989;43:33–40.
Goddard PJ, Kao YJ, Lichtenberger LM. Luminal surface hydrophobicity of gastric mucosa is dependent on a surface mucus gel. Gastroenterology. 1990;98:361–370.
Goggin PM, Northfield TC. Anatomical and biochemical basis of gastric mucosal hydrophobicity of isolated pig gastric mucosa. J Physiol. 1989;422:65P.
Nardone G, Laccetti P, Civiletti C et al. Phospholipid composition of human gastric mucosa: a study of endoscopic biopsy specimens. Gut. 1993;34:456–460.
Saita H, Murakami M, Teramura S et al. Helicobacter pylori has an ulcerogenic action in the ischemic stomach of rats. J Clin Gastroenterol. 1992;14(Suppl. l):S122–126.
Pfeiffer A, Aronbayev J, Schmidt T et al. Gastric emptying, esophageal 24-hour pH and gastric potential difference measurements in non-ulcer dyspepsia. Gastroenterol Clin Biol. 1992;16:395–400.
Fukuda T, Kimura S, Arakawa T. Possible role of leukotrienes in gastritis associated with Campylobacter pylori. J Clin Gastroenterol. 1990;12(Suppl. l):S131–134.
Taha AS, Boothman P, Holland P et al. Gastric mucosal Prostaglandin synthesis in the presence of Campylobacter pylori in patients with gastric ulcers and non-ulcer dyspepsia. Am J Gastroenterol. 1990;85:47–50.
Cryer B, Faust TW, Goldschmiedt M et al. Gastric and duodenal mucosal Prostaglandin concentrations in gastric or duodenal ulcer disease: relationships with demographics, environmental and histological factors, including Helicobacter pylori. Am J Gastroenterol. 1992;87:1747–1754.
Taha AS, Fraser WD, Kelly RW et al. Inhibition of human gastric cyclic AMP production by Helicobacter pylori protein — possible involvement of mucosal Prostaglandin E2. Aliment Pharmacol Ther. 1991;5:379–389.
Lunde OC, Kvernebo K. Gastric blood flow in patients with gastric ulcer measured by endoscopic laser doppler flowmetry. Scand J Gastroenterol. 1988;23:546–550
Bui HX, del Rosario A, Sonbati H et al. Helicobacter pylori affects the quality of experimental gastric ulcer healing in a new animal model. Exp Mol Pathol. 1991;55:261–268.
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Goggin, P., Northfield, T. (1993). Mucosal defence. In: Northfield, T., Mendall, M., Goggin, P.M. (eds) Helicobacter pylori Infection. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2216-0_7
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DOI: https://doi.org/10.1007/978-94-011-2216-0_7
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