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Pathogenesis of infections due to persistent bacteria at mucosal surfaces

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Helicobacter pylori Infection

Abstract

Helicobacter pylori and Campylobacter fetus are two spiral Gram-negative bacteria that have evolved lifestyles centred on long-term persistence in the mucus gel overlapping epithelial tissues. Since the discovery of H. pylori in 1983 there has been intense interest in this organism because of its relationship to ulcer disease, among other maladies. However, the pathophysiology of H. pylori infection is largely unknown. In this chapter I review the major points that have been learned about H. pylori pathogenesis, and then review what is known about the pathogenesis of C. fetus infection. It is hoped that bringing together information about these two different organisms that contend with parallel constraints can provide new insights.

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Authors
  1. Martin Blaser
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Editors and Affiliations

  1. Department of Medicine, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK

    T.C. Northfield (Professor of Gastroenterology), M. Mendall (Lecturer in Gastroenterology) & P. M. Goggin (Research Fellow) (Professor of Gastroenterology),  (Lecturer in Gastroenterology) &  (Research Fellow)

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© 1993 Springer Science+Business Media Dordrecht

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Blaser, M. (1993). Pathogenesis of infections due to persistent bacteria at mucosal surfaces. In: Northfield, T., Mendall, M., Goggin, P.M. (eds) Helicobacter pylori Infection. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2216-0_4

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  • DOI: https://doi.org/10.1007/978-94-011-2216-0_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4982-5

  • Online ISBN: 978-94-011-2216-0

  • eBook Packages: Springer Book Archive

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