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Cellular responses to the membrane attack complex

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Complement in Health and Disease

Part of the book series: Immunology and Medicine ((IMME,volume 20))

Abstract

Complement was first identified over a century ago as a result of the observation that fresh serum caused lysis of bacteria and erythrocytes -activities we now recognize as being mediated by the membrane attack complex (MAC). It is not surprising that, until recently, the MAC was considered by the majority of immunologists, and even by complementologists, as a lytic entity whose only role was to kill target cells. The concept that the MAC might also cause more subtle (and often more pathologically relevant) changes in target cells has only recently gained widespread recognition. This is particularly relevant when targets are nucleated and metabolically active, although important non-lethal changes may also be induced in non-nucleated cells.

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  1. B. P. Morgan
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Editors and Affiliations

  1. Department of Immunology, University of Leicester, Leicester, UK

    K. Whaley

  2. Institut für Medizinische Mikrobiologie, University of Mainz, Mainz, Germany

    M. Loos

  3. University of Iowa, Iowa City, Iowa, USA

    J. M. Weiler

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Morgan, B.P. (1993). Cellular responses to the membrane attack complex. In: Whaley, K., Loos, M., Weiler, J.M. (eds) Complement in Health and Disease. Immunology and Medicine, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2214-6_12

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  • DOI: https://doi.org/10.1007/978-94-011-2214-6_12

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