Abstract
Primary biliary cirrhosis (PBC) is a form of chronic obstructive non-suppurative granulomatous cholangitis. Females are afflicted eight times as often as males and the typical patient is in her fifth or sixth decade.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Hadziyannis. S., Scheuer, P. J., Feizi, T., Naccarato, R., Doniach, D. and Sherlock, S. (1970). Immunological and histological studies in primary biliary cirrhosis. J. Clin. Pathol., 23. 95–98
Beswick, D. R., Klatskin, G. and Boyer. J. L. (1985). Asymptomatic primary biliary cirrhosis—long term follow-up and natural history. Gastroenterology. 89. 267–271
Wight, D. G. D. (1993). Cholestasis and extrahepatic bile ducts. In Wight, D. G. D. (ed.). Liver, Biliary Tract and Exocrine Pancreas. Vol. 11. Systemic Pathology. Symmers, W. S. C., series ed. 3rd edn. Edinburgh: Churchill Livingstone
Triger, D. R. (1980). Primary biliary cirrhosis: an epidemiological study. Br. Med. J.. 281, 772–775
Krams. S. M., Surh. C. D., Coppel, R. L. Ansari, A., Ruebner, B. and Gershwin, M. E. (1989). Immunization of experimental animals with dihydrolipoamide acetyltransferase as a possible purified recombinant polypeptide generates mitochondrial antibodies but not primary biliary cirrhosis. Hepatology, 9, 411–416
Hopf, U., Moller, B., Stemerowicz, R., Lobeck, H., Rodloff, A., Freudenberg, M., Galanos, C. and Huhn, D. (1989). Relation between Escherichia colt rough-forms in gut, lipid A in liver and primary biliary cirrhosis. Lancet, 2, 1419–1421
Nakanuma, Y. and Kono, N. (1991). Expression of H LA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: an immunohistochemical study. Hum. Pathol., 22. 431–436
Epstein, O., Thomas, H. C. and Sherlock, S. (1980). Primary biliary cirrhosis is a dry gland syndrome with features of chronic graft-vshost disease. Lancet, 1, 1166–1168
Krams, S. M., Dorshkind, K. and Gershwin. M. E. (1989). Generation of biliary lesions after transfer of human lymphocytes into severe combined immuno-deficient (SCID) mice. J. Exp. Med., 170, 1919–1930
Rubin, E., Schaffner. F. and Popper, H. (1965). Primary biliary cirrhosis. Chronic non-suppurative destructive cholangitis. Am. J. Pathol., 46, 387–407
Scheuer, P. J. (1967). Primary biliary cirrhosis. Proc. Roy. Soc. Med., 60, 1257–1260
Ludwig, J., Dickson, E. R. and McDonald. G. S. A. (1978). Staging of chronic non-suppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virch. Arch. A. Path. Anat. Histol., 379. 103–112
Portmann, B., Popper, H., Neuberger, J. and Williams, R. (1985). Sequential and diagnostic features in primary biliary cirrhosis. Gastroenterology, 88. 1777–1790
MacSween, R. N. M. and Portmann, B. C. (1987). Diseases of the intrahepatic bile ducts. In MacSween, R. N. M., Anthony. P. P. and Scheuer, P. J. (eds). Pathology of the liver. 2nd edn. pp. 424–453. Edinburgh: Churchill Livingstone
Janssens, A. R., Bosman, F. T., Ruiter, D. J. and Van den Hamer, C. J. (1984). Immunohistochemical demonstration of the cytoplasmic copper-associated protein in the liver in primary biliary cirrhosis: its identification as metallothionein. Liver, 4. 139–147
Berg. P. A., Weber. P., Oehring, J., Lindenborn-Fotinos, J. and Stechemesser, E. (1985). Significance of different types of mito chondrial antibodies in primary biliary cirrhosis. In Brunner. H. and Thaler, H. (eds). Hepatology: a Festschrift for Hans Popper. pp. 231–242. New York: Raven Press
Scheuer, P. J., Ashrafzadeh, P., Sherlock, S., Brown, D. and Dusheiko, G. (1992). The pathology of hepatitis C. Hepatology, 15, 567–571
Harrison, R. F. and Hübscher, S. G. (1991). The spectrum of bile duct lesions in end-stage primary sclerosing cholangitis. Histopathology, 19, 321–327
Christensen, E., Crowe, J., Doniach, D., Popper, H., Ranek, L. Rodes, J., Tygstrup, N. and Williams, R. (1980). Clinical pattern and course of disease in PBC based on an analysis of 236 patients. Gastroenterology. 78, 286–246
Markus, B. H., Dickson, E. R., Grambsch, P. M., Fleming, T. R.. Mazzaferro, V., Klintmalm, G. B. C., Wiesner, R. H., Van Thiel, D. H. and Starzl, T. E. (1989). Efficacy of liver transplantation in patients with primary biliary cirrhosis. N. Engl. J. Med., 320, 1709–1713
Dickson, E. R.. Grambsch, P. M., Flemming. T. R.. Fisher, L. D. and Langworthy, A. (1989). Prognosis in primary biliary cirrhosis: model for decision making. Hepatology, 10, 1–7
Goudie, B. M.. Burt. A. D., Macfarlane, G. J.. Boyle, P., Gillis, C. R., MacSween, R. N. M. and Watkinson, G. (1989). Risk factors and prognosis in primary biliary cirrhosis. Am J Gastroenterol.. 84, 713–716
Neuberger, J. M. (1989). Predicting prognosis in primary biliary cirrhosis. Gut, 30, 1519–1522
Bonsel, G. J., Klompmaker, I. J., Van’T Veer, F., Habbema, J. D. F. and Slooff, M. J. H. (1990). Use of prognostic models for assessment of value of liver transplantation in primary biliary cirrhosis. Lancet. 335, 493–497
Crowe, J., Christensen. E., Smith, M., Cochrane, M., Ranek, L. Watkinson, G., Doniach, D., Popper, H., Tygstrup, N. and Williams, R. (1980). Azathioprine in PBC: a preliminary report of an international trial. Gastroenterology, 78, 1005–1010
Vierling, J. M. (1990). Primary biliary cirrhosis. In Zakim, D. and Boyer, T. D. (eds). Hepatology. A textbook of liver disease. 2nd edn. pp. 1158–1205. Philadelphia: Saunders
Wiesner, R. H.. Ludwig, J., Lindor, K. D., Jorgensen, R. A., Baldus. W. P., Homburger, H. A. and Dickson, E. R. (1990). A controlled trial of cyclosporin in the treatment of primary biliary cirrhosis. N. Engl. J. Med., 322, 1419–1424
Poupon, R. E., Balkau, B., Eschwege, E. and Poupon, R. (1991). A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. N. Engl. J. Med., 324, 1548–1554
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1993 D. G. D. Wight
About this chapter
Cite this chapter
Wight, D.G.D. (1993). Primary Biliary Cirrhosis. In: Atlas of Liver Pathology. Current Histopathology, vol 23. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2212-2_17
Download citation
DOI: https://doi.org/10.1007/978-94-011-2212-2_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4980-1
Online ISBN: 978-94-011-2212-2
eBook Packages: Springer Book Archive