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Future developments in analytical supercritical fluid technology: some ideas from recent research

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Abstract

The future development of analytical supercritical fluid technology will be guided by many factors including the research efforts of instrument manufacturers, industrialists and academics. In this final chapter we shall attempt to pose some questions where research seems to be lacking and summarise some of the current directions of research into supercritical fluids. This will hopefully seed some ideas for new research and highlight areas where this research will show application benefits. The areas can be grouped under three main sections: Theory and Understanding, Instrumentation, and Special Techniques. However, it will soon become apparent to the reader that the sections are complementary as any new special techniques require an understanding of theory and the necessary instrumentation to make them work.

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References

  • Alexandrou, N. and Pawliszyn, J., (1989), Supercritical fluid extraction for the rapid determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in municipal incinerator fly ash. Anal. Chem., 61, 2770–2776.

    Article  CAS  Google Scholar 

  • Bartle, K.D., Clifford, A.A., Hawthorne, S.B., Langenfeld, J.J., Miller, D.J. and Robinson, R., (1990), A model for dynamic extraction using a supercritical fluid. J. Supercrit. Fluids, 3, 143–149.

    Article  CAS  Google Scholar 

  • Berg, B.E., Flaaten, A.M., Paus, J. and Greibrokk, T., (1992a), Extended use of solvent venting injection techniques for large sample volumes and coupled capillary columns in SFC. J. Microcol. Sep., 4, 227–232.

    Article  CAS  Google Scholar 

  • Berg, B.E., Flaaten, A.M., Paus, J. and Greibrokk, T., (1992b), Large volume injection in capillary SFC. Basic principles and recent progress. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction,Cincinnati, OH, USA, pp. 25–26.

    Google Scholar 

  • Berger, T.A., (1992), Recent developments in packed column SFC at Hewlett-Packard. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 27–28.

    Google Scholar 

  • Berger, T.A. and Deye, J.F., (1991a), Separation of benzenepolycarboxylic acids by packed column supercritical fluid chromatography using methanol—carbon dioxide mixtures with very polar additives. J. Chromatogr. Sci., 29, 141–146.

    CAS  Google Scholar 

  • Berger, T.A. and Deye, J.F., (1991b) Efficiency in packed column supercritical fluid chromatography using a modified mobile phase. Chromatographia, 31, 529–534.

    Article  CAS  Google Scholar 

  • Berger, T.A. and Wilson, W.H., (1992), A new supercritical fluid chromatograph. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 7–8.

    Google Scholar 

  • Bicking, M.K.L., Osterheim, J.A. and Dooley, E.M., (1992), A simplified experimental design strategy for optimising SFE conditions. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, p. 40.

    Google Scholar 

  • Bruce, M.L., Stephens, M.W. and Keobler, D.J., (1992), Variflow, the water proof variable restrictor. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, p. 41.

    Google Scholar 

  • Bruno, T.J. and Ely, J.F. (Eds), (1991), Supercritical Fluid Technology: Reviews in Modern Theory and Applications. CRC Press, Boca Raton, FL, USA.

    Google Scholar 

  • Consani, K.A. and Smith, R.D., (1990), Observations on the solubility of surfactants and related molecules in carbon dioxide at 50 °C. J. Supercrit. Fluids, 3, 51–65.

    Article  CAS  Google Scholar 

  • Cortes, H.J., Campbell, R.M., Himes, R.P. and Pfeiffer, C.D., (1992a), Online coupled liquid chromatography and capillary supercritical fluid chromatography—large-volume system for capillary SFC. J. Microcol. Sep., 4, 239–244.

    Article  CAS  Google Scholar 

  • Cortes, H.J., Campbell, R.M., Green, L.S., Himes, R.P. and Pfeiffer, C.D., (1992b), Online coupled liquid chromatography and large-volume injection system for capillary SFC. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 153–154.

    Google Scholar 

  • Foley, J.P., (1992), Comparison of simplex and window diagram optimisation strategies in SFC. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, OH, USA, pp. 97–98.

    Google Scholar 

  • Francis, A.W., (1954), Ternary systems of liquid carbon dioxide. J. Phys. Chem., 58, 1099–1114.

    Article  CAS  Google Scholar 

  • Fulton, J.L., Blitz, J.P., Tingey, J.M. and Smith, R.D., (1989), Reverse micelle and microemulsion phases in supercritical xenon and ethane: light scattering and spectroscopic probe studies. J. Phys. Chem., 93, 4198–4204.

    Article  CAS  Google Scholar 

  • Furton, K.G. and Rein, J., (1991), Effect of microextractor cell geometry on supercritical fluid extraction recoveries and correlations with supercritical fluid chromatographic data. Anal. Chim. Acta, 248, 263–270.

    Article  CAS  Google Scholar 

  • Gährs, H.J., (1984), Applications of atmospheric gases in high pressure extraction. Ber. Bunsenges. Phys. Chem., 88, 894–897.

    Article  Google Scholar 

  • Gale, R.W., Fulton, J.L. and Smith, R.D., (1987a), Organized molecular assemblies in the gas phase: reverse micelles and microemulsions in supercritical fluids. J. Amer. Chem. Soc., 109,920–921.

    Article  CAS  Google Scholar 

  • Gale, R.W., Fulton, J.L. and Smith, R.D., (1987b), Reverse micelle supercritical fluid chromatography. Anal. Chem., 59, 1977–1979.

    Article  CAS  Google Scholar 

  • Hawthorne, S.B., (1990), Analytical-scale supercritical fluid extraction. Anal. Chem., 62, 633A–642A.

    CAS  Google Scholar 

  • Hawthorne, S.B. and Miller, D.J., (1987), Directly coupled supercritical fluid extraction–gas chromatographic analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls from environmental solids. J. Chromatogr., 403, 63–76.

    Article  CAS  Google Scholar 

  • Hawthorne, S.B., Krieger, M.S. and Miller, D.J., (1988a), Analysis of flavor and fragrance compounds using supercritical fluid extraction coupled with gas chromatography. Anal. Chem., 60, 472–477.

    Article  CAS  Google Scholar 

  • Hawthorne, S.B., Miller, D.J. and Krieger, M.S., (1988b), Rapid extraction and analysis of organic compounds from solid samples using coupled supercritical fluid extraction/gas chromatography. Fresenius Z. Anal. Chem., 330, 211–215.

    Article  CAS  Google Scholar 

  • Hawthorne, S.B., Miller, D.J. and Krieger, M.S., (1989), Coupled SFE–GC: a rapid and simple technique for extracting, identifying, and quantitating organic analytes from solids and sorbent resins. J. Chromatogr. Sci., 27, 347–354.

    CAS  Google Scholar 

  • Hawthorne, S.B., Langenfeld, J.J., Miller, D.J. and Burford, M.D., (1992a), Comparison of supercritical CHC1F2, N2O and CO2 for the extraction of polychlorinated biphenyls and polycyclic aromatic hydrocarbons. Anal. Chem., 64, 1614–1622.

    Article  CAS  Google Scholar 

  • Hawthorne, S.B., Miller, D.J., Nivens, D.E. and White, D.C., (1992b), Supercritical fluid extraction of polar analytes using in situ chemical derivatization. Anal. Chem., 64, 405–412.

    Article  CAS  Google Scholar 

  • Hills, J.W., Hill, H.H. and Maeda, T., (1991a), Simultaneous supercritical fluid derivatisa-tion and extraction (SFDE). International Symposium on Supercritical Fluid Chromatography and Extraction, Park City, Utah, USA, pp. 113–114.

    Google Scholar 

  • Hills, J.W., Hill, H.H. and Maeda, T., (1991b), Simultaneous supercritical fluid derivatization and extraction. Anal. Chem., 63, 2152–2155.

    Article  CAS  Google Scholar 

  • Ho, J.S. and Tang, P.H., (1992), The simplex optimisation of supercritical fluid extraction of organics in a liquid—solid extraction cartridge. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 37–38.

    Google Scholar 

  • Hoefling, T.A., Enick, R.M. and Beckman, E.J., (1991), Microemulsions in near-critical and supercritical CO2. J. Phys. Chem., 95, 7127–7129.

    Article  CAS  Google Scholar 

  • Howdle, S.M., Jobling, M., Healy, M. and Poliakoff, M., (1991), Spectroscopic investigations of organometallic chemistry in supercritical fluids. Symposium on Spectroscopic Investigations in Supercritical Fluids, 201st American Chemical Society National Meeting, Atlanta, USA, Paper ANYL-2.

    Google Scholar 

  • Huang, E.B. and Pawliszyn, J., (1992), Statistical experimental design for optimisation and understanding of SFE of organic contaminants from soil samples. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, p. 39.

    Google Scholar 

  • Jobling, M., Howdle, S.M., Healy, M.A. and Poliakoff, M., (1990), Photochemical activation of carbon—hydrogen bonds in supercritical fluids: the dramatic effect of dihydrogen on the activation of ethane by [(η5-C5ME5)Ir(CO)2]. J. Chem. Soc., Chem. Commun., 1287–1290.

    Google Scholar 

  • Johnston, K.P., (1989), New directions in supercritical fluid science and technology. In Supercritical Fluid Science and Technology, ACS Symposium Series 406, American Chemical Society, Washington, DC, USA, pp. 1–12.

    Chapter  Google Scholar 

  • Johnston, K.P., Gupta, R., McFann, G. and Peck, D., (1992), Cosolvents, complexing agents, and organised molecular assemblies for enhanced solubilisation in SFE and SFC. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 33–34.

    Google Scholar 

  • Kaler, E.W., Billman, J.F., Fulton, J.L. and Smith, R.D., (1991), A small-angle neutron scattering study of intermicellar interactions in microemulsions of AOT, water, and near-critical propane. J. Phys. Chem., 95, 458–462.

    Article  CAS  Google Scholar 

  • Knowles, D.E. and Richter, B.E., (1991), The use of modified mobile phases in SFC: effects on the retention and stability of selected pesticides. J. High Resolut. Chromatogr., Chromatogr. Commun., 14, 689–691.

    CAS  Google Scholar 

  • Koski, I.J., Lee, E.D. and Lee, M.L., (1992), Solid phase injector for open tubular column SFC. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 13–14.

    Google Scholar 

  • Laintz, K.E., Wai, C.M., Yonker, C.R. and Smith, R.D., (1991), Solubility of fluorinated metal diethyldithiocarbamates in supercritical carbon dioxide. J. Supercrit. Fluids, 4, 194–198.

    Article  CAS  Google Scholar 

  • Langenfield, J.J., Burford, M.D., Hawthorne, S.B. and Miller, D.J. (1992), Effects of collection solvent parameters and extraction cell geometry on supercritical fluid extraction efficiencies. J. Chromatogr., 594, 297–307.

    Article  Google Scholar 

  • Lee, M.L. and Markides, K.E., (Eds), (1990), Analytical Supercritical Fluid Chromatography and Extraction. Chromatography Conferences, Provo, UT, USA.

    Google Scholar 

  • Lemert, R.M., Fuller, R.A. and Johnston, K.P., (1990), Reverse micelles in supercritical fluids. 3. Amino acid solubilization in ethane and propane. J. Phys. Chem., 94, 6021–6028.

    Article  CAS  Google Scholar 

  • Levy, J.M. and Guzowski, J.P., (1988), Characterization of gasolines using online multidimensional supercritical fluid extraction/capillary gas chromatography. Fresenius Z. Anal. Chem., 330, 207–210.

    Article  CAS  Google Scholar 

  • Levy, J.M. and Rosselli, A.C., (1989), Quantitative supercritical fluid extraction coupled to capillary gas chromatography. Chromatographia, 28, 613–616.

    Article  CAS  Google Scholar 

  • Levy, J.M., Guzowski, J.P. and Huhak, W.E., (1987), On-line multidimensional supercritical fluid chromatography/capillary gas chromatography. J. High Resolut. Chromatogr. Chromatogr. Commun., 10, 337–341.

    Article  CAS  Google Scholar 

  • Levy, J.M., Storozynsky, E. and Ravey, R.M., (1991), The use of alternative fluids in on-line supercritical fluid extraction—capillary gas chromatography. J. High Resolut. Chromatogr., Chromatogr. Commun., 14, 661–666.

    Article  CAS  Google Scholar 

  • Leyendecker, D., Leyendecker, D., Schmitz, F.P. and Klesper, E., (1987), Comparison of eluents in supercritical fluid chromatography. J. Liquid Chromatogr., 10, 1917–1947.

    Article  CAS  Google Scholar 

  • Liu, Z.Y., Farnsworth, P.B. and Lee, M.L., (1992), High-speed, thermally modulated SFEGC for the analysis of volatile organic compounds in solid matrices. J. Microcol. Sep., 4, 199–208.

    Article  CAS  Google Scholar 

  • Lopez-Avila, V. and Dodhiwala, N.S., (1990), Supercritical fluid extraction and its application to environmental analysis. J. Chromatogr. Sci., 28, 468–476.

    CAS  Google Scholar 

  • Lynch, T.P., (1991), Analytical applications of supercritical fluid extraction in the petroleum and petrochemical industry. Second International Symposium on Supercritical Fluids, Boston, MA, USA, pp. 437–440.

    Google Scholar 

  • Lynch, T.P., Roberts, I., Escott, R.E.A. and Carrott, M.J., (1991), Analytical applications of supercritical fluid extraction in the petroleum and petrochemical industry. Chromatographic Society Symposium on Extraction and Chromatography with Supercritical Fluids, Keele, UK, p. 3.

    Google Scholar 

  • Lynch, T.P., Escott, R.E.A., McDowell, P.G., Roberts, I. and Carrott, M.J., (1992), SFE for hyphenated techniques: applications from the petroleum and chemical industry. In Proceedings of the 4th International Symposium on Supercritical Fluid Chromatography and Extraction, Cincinnati, OH, USA, pp. 179–180.

    Google Scholar 

  • McHugh, M.A. and Krukonis, V.J., (1986), Supercritical Fluid Extraction: Principles and Practice. Butterworth, Boston, MA, USA.

    Google Scholar 

  • Miller, D.J., Hawthorne, S.B., Langenfeld, J.J. and White, D.C., (1991), SFE with chemical derivatisation for the recovery of polar and ionic analytes. International Symposium on Supercritical Fluid Chromatography and Extraction, Park City, UT, USA, pp. 155–156.

    Google Scholar 

  • Morrissey, M.A., Giorgetti, A., Polasek, M., Pericles, N. and Widner, H.M., (1991), Pressure and modifier programming in packed-column supercritical fluid chromatography. J. Chromatogr. Sci., 29, 237–242.

    CAS  Google Scholar 

  • Pickel, K.H., (1991), Influence of ‘negative’ modifiers by the separation of aromatic hydrocarbons. Second International Symposium on Supercritical Fluids, Boston, MA, USA, pp. 457–458.

    Google Scholar 

  • Raynie, D.E., Markides, K.E., Lee, M.L. and Goates, S.R., (1989), Back-pressure regulated restrictor for flow control in capillary supercritical fluid chromatography. Anal. Chem., 61, 1178–1181.

    Article  CAS  Google Scholar 

  • Reid, R.C., Prausnitz, J.M. and Poling, B.E., (1987), The Properties of Gases and Liquids, 4th edn. McGraw-Hill, New York, NY, USA.

    Google Scholar 

  • Rein, J., Cork, C.M. and Furton, K.G., (1991), Factors governing the analytical supercritical fluid extraction and supercritical fluid chromatographic retention of polycyclic aromatic hydrocarbons. J. Chromatogr., 545, 149–160.

    Article  CAS  Google Scholar 

  • Saito, M. and Yamauchi, Y., (1988), Recycle chromatography with supercritical fluid carbon dioxide as mobile phase. J. High Resolut. Chromatogr., Chromatogr. Commun., 11,741–743.

    Article  CAS  Google Scholar 

  • Saito, M., Yamauchi, Y., Kashiwazaki, H. and Sugawara, M., (1988), New pressure regulating system for constant mass flow supercritical-fluid chromatography and physicochemical analysis of mass-flow reduction in pressure programming by analogous circuit model. Chromatographia, 25, 801–805.

    Article  CAS  Google Scholar 

  • Schmitz, F.P. and Klesper, E., (1990), Separation of oligomers and polymers by supercritical fluid chromatography. J. Supercrit. Fluids, 3, 29–48.

    Article  CAS  Google Scholar 

  • SF-SolverTM, (1991), Software for Supercritical Fluid Analysis. Isco Inc., Lincoln, NB, USA.

    Google Scholar 

  • Smith, R.D., Fulton, J.L., Blitz, J.P. and Tingey, J.M., (1990), Reverse micelles and microemulsions in near-critical and supercritical fluids. J. Phys. Chem., 94, 781–787.

    Article  CAS  Google Scholar 

  • Tingey, J.M., Fulton, J.L. and Smith, R.D., (1990), Interdroplet attractive forces in AOT water-in-oil microemulsions formed in subcritical and supercritical solvents. J. Phys. Chem., 94, 1997–2004.

    Article  CAS  Google Scholar 

  • Verillon, F., Heems, D., Pichon, B., Marin Martinod, T. and Robert, J.C., (1991a), Supercritical fluid chromatograph with independent programming of mobile phase pressure, composition and flow rate. 1st Italian Congress on Supercritical Fluids and their Applications, Amalfi, Italy, 24–25 June.

    Google Scholar 

  • Verillon, F., Heems, D., Pichon, B., Marin Martinod, T. and Robert, J.C., (1991b), Supercritical fluid chromatograph with independent programming of mobile phase press-ure, composition and flow rate. 2ème Colloque sur les Fluides Supercritiques,Paris, France, 16–17 October.

    Google Scholar 

  • Wheeler, J.R. and McNalley, M.E., (1989), Supercritical fluid extraction and chromatography of representative agricultural products with capillary and microbore columns. J. Chromatogr. Sci., 27, 534–539.

    CAS  Google Scholar 

  • White, D.C., Nivens, D.E., Ringelberg, D., Hedrick, D. and Hawthorne, S.B., (1991), SFE/ derivatisation for rapid GC/MS identification of bacteria and bacterial products. International Symposium on Supercritical Fluid Chromatography and Extraction, Park City, UT, USA, pp. 43–44.

    Google Scholar 

  • Yazdi, P., McFann, G.J., Fox, M.A. and Johnston, K.P., (1990), Reverse micelles in supercritical fluids. 2. Fluorescence and absorption spectral probes of adjustable aggregation in the two-phase region. J. Phys. Chem., 94, 7224–7232.

    Article  CAS  Google Scholar 

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Lynch, T.P. (1993). Future developments in analytical supercritical fluid technology: some ideas from recent research. In: Dean, J.R. (eds) Applications of Supercritical Fluids in Industrial Analysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2146-0_8

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