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Chemistry of Iron pp 275–299Cite as

Iron chelators of clinical significance

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Abstract

Until relatively recently chelating agents have been considered to form a small esoteric group of pharmaceuticals with little relevance to general medicine. Penicillamine, for instance, has been used to treat Wilson’s disease for over 35 years, and desferrioxamine has found application for the treatment of transfusion-induced iron overload in thalassaemic patients for almost 20 years. This limited interest is surprising as Fe, Cu, Zn, Ca and Mg all have a critical involvement in cell biochemistry and it would seem likely that chelating agents might find roles in rectifying abnormal distribution of these metals and enhancing their absorption from the gastrointestinal tract.

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Authors
  1. R. C. Hider
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  2. S. Singh
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Editors and Affiliations

  1. Department of Chemistry and Biological Chemistry, University of Essex, UK

    J. Silver

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© 1993 Springer Science+Business Media Dordrecht

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Hider, R.C., Singh, S. (1993). Iron chelators of clinical significance. In: Silver, J. (eds) Chemistry of Iron. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2140-8_8

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  • DOI: https://doi.org/10.1007/978-94-011-2140-8_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4948-1

  • Online ISBN: 978-94-011-2140-8

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