Abstract
Microbicides of this kind are electrophilic active substances having at their disposal an activated halogen group in the α-position and/or in the vinyl position to an electronegative group E (Fig. 34). The antimicrobial activity of these substances arises from the fact that nucleophilic entities (H-Nul) of the microbial cell react with the positive carbon atom of the substances. It is apparent that a variety of modifications of both the electronegative group E and the portion of the molecule bearing the halogen group are possible. Thus microbicides having a wide range of chemical and physical properties have been synthesized within this group of active ingredients.
Sources for toxicity data, if not otherwise indicated: Registry of toxic effects of chemical substances (1990). Department of Health and Human Services, Cincinnati, USA. Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und angrenzende Gebiete (1989), Ed. H P. Fiedler, Editio Cantor, Aulendorf Germany. Product information and safety data sheets of microbicide suppliers. All indications are given in good faith and conscience. This also applies for the ’maximum working place concentrations’ (MWC), the ’acceptable daily intake’ (ADI) values and to the data with regard to ecotoxicity and biodegradability of microbicides which, as far as accessible, were also incorporated.
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© 1993 Springer Science+Business Media Dordrecht
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Paulus, W. (1993). Compounds with Activated Halogen Groups. In: Microbicides for the Protection of Materials. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2118-7_17
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DOI: https://doi.org/10.1007/978-94-011-2118-7_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4939-9
Online ISBN: 978-94-011-2118-7
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