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The roles of cytochrome P450 in nicotine metabolism

  • Chapter
Nicotine and Related Alkaloids

Abstract

The conversion of nicotine to cotinine is a major pathway of nicotine metabolism and cytochrome P450 catalyses the first step of this pathway (Nakayama, 1988). To date, numerous studies have shown that cytochrome P450 is composed of many molecular forms and their expression is regulated by many factors such as drug administration, age, sex and pathophysiological conditions (Ryan and Levin, 1990; Soucek and Gut, 1992; Funae and Imaoka, 1992).

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Authors
  1. H. Nakayama
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  2. T. Kita
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  3. T. Nakashima
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  4. S. Imaoka
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  5. Y. Funae
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Editor information

Editors and Affiliations

  1. Chelsea Department of Pharmacy, King’s College, London, UK

    J. W. Gorrod

  2. Department of Clinical Physiology, Karolinska Institute, Stockholm, Sweden

    J. Wahren

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© 1993 Springer Science+Business Media Dordrecht

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Nakayama, H., Kita, T., Nakashima, T., Imaoka, S., Funae, Y. (1993). The roles of cytochrome P450 in nicotine metabolism. In: Gorrod, J.W., Wahren, J. (eds) Nicotine and Related Alkaloids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2110-1_3

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  • DOI: https://doi.org/10.1007/978-94-011-2110-1_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4936-8

  • Online ISBN: 978-94-011-2110-1

  • eBook Packages: Springer Book Archive

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