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Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells

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Molecular Chaperones

Summary

In response to either elevated temperatures or several other metabolic insults, cells from all organisms respond by increasing the expression of so-called heat shock proteins (hsp or stress proteins). In general, the stress response appears to represent a universal cellular defence mechanism. The increased expression and accumulation of the stress proteins provides the cell with an added degree of protection. Studies over the past few years have revealed a role for some of the stress proteins as being intimately involved in protein maturation. Members of the hsp 70 family, distributed throughout various intracellular compartments, interact transiently with other proteins undergoing synthesis, translocation, or higher ordered assembly. Although not yet proven, it has been suggested that members of the hsp 70 family function to slow down or retard the premature folding of proteins in the course of synthesis and translocation. Yet another family of stress proteins, the hsp 60 or GroEL proteins (chaperonins), appear to function as catalysts of protein folding. Here I discuss the role of those stress proteins functioning as molecular chaperones, both within the normal cell and in the cell subjected to metabolic stress.

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Authors
  1. N. J. Welch
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Editors and Affiliations

  1. Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK

    R. J. Ellis (Professor of Biological Sciences) (Professor of Biological Sciences)

  2. Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK

    R. A. Laskey

  3. Central Research and Development Department, DuPont Company Experimental, Station E402, Wilmington, Delaware, 19880, USA

    G. H. Lorimer

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© 1993 Springer Science+Business Media Dordrecht

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Welch, N.J. (1993). Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells. In: Ellis, R.J., Laskey, R.A., Lorimer, G.H. (eds) Molecular Chaperones. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2108-8_9

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  • DOI: https://doi.org/10.1007/978-94-011-2108-8_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4935-1

  • Online ISBN: 978-94-011-2108-8

  • eBook Packages: Springer Book Archive

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