Abstract
Prodigiosin 25-C (PrG) suppresses induction of killer T cells without inhibiting functions of B cells and helper T cells. To explore the mechanism of the specific immunosuppression of the antibiotic, we treated naive mice with PrG and evaluated functions of T cells and macrophages in the spleen by mixed lymphocyte reaction (MLR). Our results indicated that PrG inhibits allogeneic major histocompatibility antigen complex (MHC)-specific stimulator function of macrophages but not response of T cells. Presentation of exogenous antigen was rather enhanced. These results suggest that PrG inhibits induction of killer T cells through selective inhibition of alloantigen presentation of macrophages.
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© 1993 Springer Science+Business Media Dordrecht
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Magae, J. et al. (1993). Suppression of Killer T Cell Induction by Prodigiosin 25-C. In: Kaminogawa, S., Ametani, A., Hachimura, S. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2044-9_21
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DOI: https://doi.org/10.1007/978-94-011-2044-9_21
Publisher Name: Springer, Dordrecht
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