Abstract
Obesity which is characterized by abnormal adipose tissue development is a first degree public health hazard in industrialized countries as it is accompanied by a high incidence of cardiovascular disease, diabetes and elevated morbidity. One important aspect in the study of adipose tissue development is to investigate the hormonal control of adipose differentiation. In particular, if negative regulators of differentiation can be identified, than they can be used to develop a therapeutic approach towards the control of excessive adipose tissue development in human subjects. The data presented here describe the identification of epidermal growth factor as a potent inhibitor of adipose differentiation both in vitro and in vivo. Moreover, evidence are presented that genetically obese ob/ob mice present an impaired level of EGF thus demonstrating for the first time the existence of a correlation between low level of the adipose differentiation inhibitor EGF and excessive adipose tissue development.
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© 1993 Springer Science+Business Media Dordrecht
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Serrero, G. (1993). From in Vitro Cell Culture to in Vivo Animal Study: Demonstration that Epidermal Growth Factor (EGF) Is a Potent Inhibitor of Adipose Differentiation.. In: Kaminogawa, S., Ametani, A., Hachimura, S. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2044-9_19
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DOI: https://doi.org/10.1007/978-94-011-2044-9_19
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