Abstract
The cytochrome P-450 IIIA, a major constitutive isoenzyme of human liver drug-metabolizing enzymes, is responsible for the metabolism of cyclosporine (CSA) (1,2,3). The catalytic activity of this isoenzyme varies up to twenty-fold between patients and could explain the wide individual variability in plasma levels upon administration of equal doses (2). This may have implications for its benefits and risks (e.g. neurotoxicity and renal failure) (4). In general, renal and neurological toxicities of CSA are associated with high levels of drug in blood. However, CSA can induce renal and neurological dysfunctions in some patients while blood levels of parent drug are not elevated (5, 6).
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Bibliography
Bertault-pères P., Bonfils C., Fabre G., Just S., Cano J.P., and Maurel P. (1897): Drug Metab. Dispos., 15: 391–397.
Kronbach T., Fischer V. and Meyer U.A. (1988): Clin. Pharmacol. Ther., 43: 630–635.
Lucey M.R., Kolars J.C., Merion R.M., Campbell D.A., Aldrich M., and Watkins P.B. (1990): Lancet, 35: 11–15.
Ptachinski R.J., Venkataramanan R., and Burckart G.J. (1986), Clin. Pharmacokin., 11: 107–132.
Kahan B.D. and Grevel J. (1988): Transplantation, 46: 631–644.
De Groen P.C., Aksanut A.J., Rakela J., Forbes G.S. and Krom R.A.F. (1987): N. Engl. J. Med., 317: 861–866.
Ged C., Rouillon J.M., Pichard L., Combalbert J., Bressot N., Michel H., Beaune P. and Maurel P. (1989): Br. J. Clin. Pharmacol., 28: 373–387.
Donats P., Abish E., Homberger M., Trahar R. and Trapp M. (1981): Journal of immunoassay, 2: 19–32.
Drug interactions of cyclosporine (1986): Aust. J. Pharm., 67: 848–849.
Godin J.R.P., Sketris I.S. and Belitsky P. (1986): Drug Intell. Clin. Pharm., 20: 504–505.
Pochet J.M. and Pirson Y. (1986): Lancet, i:979.
Lindhom A. and Henricsson S. (1987): Lancet, i:1262–1263.
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© 1993 Springer Science+Business Media Dordrecht
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Lemoine, A. et al. (1993). Urinary 6-ß Hydroxycortisol as a Predictor of Cyclosporine Blood Levels. In: Galmarini, D., Fassati, L.R., Paoletti, R., Sherlock, S. (eds) Drugs and the Liver: High Risk Patients and Transplantation. Medical Science Symposia Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1994-8_26
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DOI: https://doi.org/10.1007/978-94-011-1994-8_26
Publisher Name: Springer, Dordrecht
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