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24 Hour-Hypothermic Preservation of Rat Liver with Euro-Collins and UW Solutions. Comparative Evaluation by 31P NMR Spectroscopy, Biochemical Assays and Light Microscopy

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Drugs and the Liver: High Risk Patients and Transplantation

Part of the book series: Medical Science Symposia Series ((MSSS,volume 4))

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Abstract

Advances in liver preservation had been slow, until Jamieson et al. (1) described a successful long-term cold-preservation of the dog liver based on the use of a lactobionatecontaining solution. However, additional progress has remained limited for two reasons. First, the mechanisms responsible for cellular injury induced by cold-ischemic preservation are not fully understood due to the complexity of events occurring during storage and reperfusion. Second, the evaluation of the metabolic status of the transplant during ischemia and reperfusion has lacked adequate invasive and non-invasive methodologies.

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Authors
  1. J-M. Gulian
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  2. C. Dalmasso
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  3. S. Masson
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  4. F. Desmoulin
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  5. C. Scheiner
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  6. M. Charrel
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  7. P. J. Cozzone
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Editor information

Editors and Affiliations

  1. Institute of Surgical Researches and Transplantation, Ospedale Maggiore Policlinico di Milano, University of Milan, Milan, Italy

    D. Galmarini  & L. R. Fassati  & 

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  3. Royal Free Hospital School of Medicine, University of London, London, UK

    S. Sherlock

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© 1993 Springer Science+Business Media Dordrecht

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Gulian, JM. et al. (1993). 24 Hour-Hypothermic Preservation of Rat Liver with Euro-Collins and UW Solutions. Comparative Evaluation by 31P NMR Spectroscopy, Biochemical Assays and Light Microscopy. In: Galmarini, D., Fassati, L.R., Paoletti, R., Sherlock, S. (eds) Drugs and the Liver: High Risk Patients and Transplantation. Medical Science Symposia Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1994-8_13

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  • DOI: https://doi.org/10.1007/978-94-011-1994-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5748-6

  • Online ISBN: 978-94-011-1994-8

  • eBook Packages: Springer Book Archive

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