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Serotonergic Pharmacology of Appetite

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Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

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Abstract

Feeding is influenced by 5-HTergic drugs. Thus, 5-HT1A agonists cause hyperphagia in freely feeding rats by activating raphe presynaptic 5-HT1A receptors so that extracellular 5-HT at terminals is decreased. 5-HT1B and 5-HT1C agonists cause hypophagia in freely feeding or food-deprived rats by acting on hypothalamic postsynaptic receptors. Dfenfluramine (d-F) increases brain extracellular 5-HT but its hypophagic effect and that of its metabolite d-norfenfluramine (d-NF) survive 5-HT depletion. In the case of d-NF, results suggest a direct action at 5-HT1C sites. As appetite disorders are more frequent in females, sex differences in these mechanisms are considered. Results in general have implications for the understanding and control of disorders of appetite.

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Authors and Affiliations

  1. Institute of Neurology, Wakefield Street, London, WC1N, 1PJ, UK

    G. Curzon, E. L. Gibson, A. J. Kennedy & A. O. Oluyomi

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  1. G. Curzon
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  2. E. L. Gibson
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  3. A. J. Kennedy
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  4. A. O. Oluyomi
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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© 1993 Springer Science+Business Media Dordrecht

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Curzon, G., Gibson, E.L., Kennedy, A.J., Oluyomi, A.O. (1993). Serotonergic Pharmacology of Appetite. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_46

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  • DOI: https://doi.org/10.1007/978-94-011-1920-7_46

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