Skip to main content
SpringerLink
Log in
Book cover

Serotonin pp 367–374Cite as

Serotonin Mechanisms in Ethanol Abuse

  • Chapter
  • First Online:

  • 158 Accesses

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

Abstract

Serotonergic (5-HT) receptor systems have been implicated in the control of many ethanol-related behaviors, such as voluntary ethanol consumption, anxiety-like behaviors during ethanol withdrawal, discrimination of ethanol as a stimulus, and modulation of ethanol intoxication. Several classes of serotonin receptors (5-HT1A5-HT,,, 5-HT, and 5-HT,) may be important in mechanisms underlying the development and/or maintenance of ethanol tolerance and dependence by modulating emotions (anxiety), homeostasis, and adaptive processes. The impact of drugs selective for various types of serotonin receptors are discussed in relation to their effect on anxiety-like behaviors during ethanol withdrawal and voluntary ethanol consumption.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Soubrie, P. (1986) ‘Reconciling the role of central serotonin neurons in human and animal behaviour’, Behay. Brain Sci. 9, 319–364.

    Article  Google Scholar 

  2. Wong, D.T., Threlkeld, P.G., Lumeng, L., and Li, T.-K. (1990) ‘Higher density of serotonin-1A receptor in the hippocampus and cerebral cortex of alcohol-preferring P rats’, Life Sci. 46, 231–235.

    Article  CAS  Google Scholar 

  3. Harris, R.A., Brodie, M.S., and Dunwiddie, T.V. (1992) ‘Possible substrates of ethanol reinforcement: GABA and dopamine’, Ann. N.Y. Acad. Sci. 654, 61–69.

    Article  CAS  Google Scholar 

  4. Imperato, A. and DiChiara, G. (1986) ‘Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol’, J. Pharmacol. Exp. Ther. 239, 219–228.

    PubMed  CAS  Google Scholar 

  5. Fadda, F., Mosca, E., Colombo, G., and Gessa, G.L. (1990) ‘Alcohol-preferring rats: Genetic sensitivity to alcohol induced stimulation of dopamine metabolism’, Physiol. Behay. 47, 727–729.

    Article  CAS  Google Scholar 

  6. Hoyer, D., (1988) ‘Functional correlates of serotonin 1 recognition sites’, J. Recept. Res. 8, 59–81.

    Article  CAS  Google Scholar 

  7. Zhou, F.C., Bledsoe, S., Lumeng, L., and Li, T.-K. (1990) ‘Serotonergic immunostained terminal fibers are decreased in selected brain areas of alcohol-preferring P rats’, Alc: Clin. Exp. Res. 14, 355A.

    Google Scholar 

  8. Lal, H., Rezazadeh, S.M., and Prather, P.L. (1993) ‘Potential role of 5-HTIc and/or 5-HT2 receptors in mianserin-induced prevention of anxiogenic behaviors occurring during ethanol withdrawal’, Alc: Clin. Exp. Res., in press.

    Google Scholar 

  9. Rezazadeh, S.M., Prather, P.L., and Lal, H. (1993) ‘Sensitization to 5-HTIc receptor agonist in rats observed following withdrawal from chronic ethanol’, Alcohol 10, in press.

    Google Scholar 

  10. DerKach, V., Suprenant, A., and North, R.A. (1989)’5-HT3 receptors are membrane ion channels’, Nature 339, 706–709.

    Article  CAS  Google Scholar 

  11. Kilpatrick, G.J., Jones, B.J., and Tyer, M.B. (1987) ‘Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding’, Nature 330, 746–748.

    Article  CAS  Google Scholar 

  12. Lovinger, D.M. (1991) ‘Ethanol potentiates ion current mediated by 5-HT3 receptors on neuroblastoma cells and isolated neurons’, Alcohol and Alcoholism Suppl. 1, pp. 181–185.

    CAS  Google Scholar 

  13. Chen, J., van Praag, H.M., and Gardner, E.L. (1991) ‘Activation of 5-HT3 receptors by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens’, Brain Res. 543, 354–357.

    Article  CAS  Google Scholar 

  14. Jiang, L.H., Ashby, C.R., Jr., Kasser, R.J., and Wang, R.Y. (1990)’The effect of intraventricular administration of the 5-HT3 receptor agonist 2methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study’, Brain Res. 513, 156–160.

    Article  CAS  Google Scholar 

  15. Wozniak, K.M., Pert, A. and Linnoila, M. (1990) ‘Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine’, Eur. J. Pharmacol. 187, 287–289.

    Article  CAS  Google Scholar 

  16. Prather, P.L. and Lal, H. (1991) ‘Protracted withdrawal: Sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol’, Neuropsychopharm. 6, 23–29.

    Google Scholar 

  17. Lal, H. and Emmett-Oglesby, M.W. (1983) ‘Behavioral analogues of anxiety: animal models’, Neuropharmacology 22, 1423–1441.

    Article  CAS  Google Scholar 

  18. Lal, H., Harris, C.M., Benjamin, D., Springfield, A.C., Bhadra, S., and Emmett-Oglesby, M.W. (1988) ‘Characterization of a pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal’, J. Pharmacol., Exp. Ther. 247, 508–518.

    CAS  Google Scholar 

  19. Pellow, S., Johnston, A.L., and File, S.E. (1987) ‘Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat’, J. Pharm. Pharmacol. 39, 917–928.

    Article  CAS  Google Scholar 

  20. Lal, H., Prather, P.L., and Rezazadeh, S.M. (1991) ‘Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: Reversal by buspirone’, Alcohol 8, 467–471.

    Article  CAS  Google Scholar 

  21. Benjamin, D., Saiff, E.I., Coupet, J., and Lal, H. (1990) ‘Down regulation of brain 5-HT2 receptors underlies anxiolytic affect produced by sustained treatment with gepirone’, Soc. for Neurosci. Abs. 16, 1323.

    Google Scholar 

  22. Lal, H., Rezazadeh, S.M., and Prather, P.L. (1991) ‘Clozapine reverses anxiogenic behaviors observed during ethanol withdrawal’, Pharmacologist 33, 165.

    Google Scholar 

  23. Wallis, C.J., Rezazadeh, S.M., and Lal, H. (1992) ‘Behavioral evidence for down-regulation of 5HT3 receptors produced by chronic ethanol’, Soc. Neurosci. Abst. 18, 1431.

    Google Scholar 

  24. Jones, B.J., Costall, B., Domeney, A.M., Kelly, M.E., Naylor, R.J., Oakley, N.R., and Tyers, M.B. (1988) ‘The potential anxiolytic activity of GR38032F, a 5-HT3 receptor antagonist’, Br. J., Pharmacol. 93, 985–993.

    Article  CAS  Google Scholar 

  25. File, S.E. and Johnston, A.L. (1989) ‘Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat’, Psychopharmacol. 99, 248–251.

    Article  CAS  Google Scholar 

  26. Kornetsky, C., Bain, G.T., Unterwald, E.M., and Lewis, M.J. (1988) ‘Brain stimulation reward: Effects of ethanol’ Alc: Clin. Exp. Res. 12, 609–616.

    CAS  Google Scholar 

  27. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989) ‘Serotonin and ethanol preference’, in M. Galanter (ed.), Recent developments in alcoholism vol. 7, pp. 187–209.

    Article  CAS  Google Scholar 

  28. Naranjo, C., Sellers, F.M., Sullivan, J.T., Woodley, D.V., Kadlec, K., and Sykora, K. (1987) ‘The serotonin uptake inhibitor citalopram attenuates ethanol intake’, Clin. Pharmacol. Ther. 41, 266–274.

    Article  CAS  Google Scholar 

  29. Privette, T.H. Hornsby, R.L., Myers, R.D. (1988) ‘Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways’, Alcohol 5, 147–152.

    Article  CAS  Google Scholar 

  30. Sellers, E.M., Kaplan, H.L., Lawrin, M.D., Somer, C.A., Naranjo, C.A., and Frecker, R.C. (1988) ‘The 5-HT3 antagonist GR38032F decreases alcohol consumption in rats’, Soc. Neurosci. Abst. 14, 41.

    Google Scholar 

  31. Meert, T.F. and Janssen, P.A.J. (1991) ‘Ritanserin, a new therapeutic approach for drug abuse. Part 1: Effects on alcohol’, Drug Dev. Res. 24, 235–249.

    CAS  Google Scholar 

  32. Grant, K.A. (1990) ‘5-HT3 Antagonists block behavioral effects of ethanol’, Alc: Clin. Exp. Res. 14, 294.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Texas College of Osteopathic Medicine, 3500 Camp Bowie Boulevard, Fort Worth, Texas, 76107, USA

    H. Lal, S. M. Rezazaden & C. J. Wallis

Authors
  1. H. Lal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Rezazaden
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. J. Wallis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Lal, H., Rezazaden, S.M., Wallis, C.J. (1993). Serotonin Mechanisms in Ethanol Abuse. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_43

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1920-7_43

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation