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Serotonergic Regulation of Natural Killer Cells: A Minireview

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Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

Abstract

Natural killer (NK) cells are a subset of lymphocytes that kill tumor cells and virus-infected target cells in a non-MHC-restricted fashion. Serotonin augments several functions of human NK cells, including anti-tumor cytotoxicity, proliferation, and lymphokine production by an indirect mechanism of action. Thus, activation of 5-HT1Atype receptors abrogates a cell-contact-dependent suppressive signal delivered to NK cells by monocytes and granulocytes. The suppressive signal is closely related to the ‘respiratory burst’ activity of monocytes/granulocytes since catalase, a scavenger of reactive oxygen metabolites, abrogates the suppression as effectively as serotonin. Further, serotonin depresses the generation of oxygen metabolites by monocytes and granulocytes. The presented data are suggestive of a novel type of communication between subsets of leukocytes involved in nonadaptive immunity and its serotonergic regulation.

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Author information

Authors and Affiliations

  1. Department of Virology, University of Göteborg, Sweden

    Kristoffer Hellstrand & Svante Hermodsson

  2. Institute of Medical Microbiology, University of Göteborg, Sweden

    Claes Dahlgren

Authors
  1. Kristoffer Hellstrand
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  2. Claes Dahlgren
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  3. Svante Hermodsson
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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© 1993 Springer Science+Business Media Dordrecht

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Hellstrand, K., Dahlgren, C., Hermodsson, S. (1993). Serotonergic Regulation of Natural Killer Cells: A Minireview. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_40

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  • DOI: https://doi.org/10.1007/978-94-011-1920-7_40

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

  • eBook Packages: Springer Book Archive

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