Abstract
Functional interactions between the central nervous system and the immune system occur through as a complex network involving neurotransmitters, hormones, and cytokines. The serotoninergic system likely plays a role in these interactions.
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References
Metalnikov, S. (1931) Role du système nerveux et des réflexes conditionnels dans l’immunité, Ann. Institut Pasteur 46, 137–168.
Ader, R. (ed.) (1981) Psychoneuroimmunology, Academic Press, New York.
Weigent, D.A. and Blalock, J.E. (1987) Interactions between the neuroendocrine and immune systems: common hormones and receptors, Immunological Rev. 100, 79.
Besedovsky, H.O., del Rey, A., and Sorkin, E. (1985)Immunoneuroendocrine interactions, J. Immun. 135, 750s-754s.
Ader R Felten D., and Cohen N. (1990) Interactions between the brain and the immune system, Annu. Rev. Pharmacol. Toxicol. 30, 561–602.
Davis, R.B. (1968) Discussion of the role of 5-hydroxyindoles in the carcinoid syndrome, Advances in Pharmacol. 6, 146–149.
Boranic, M., Pericic, D., Poljak-Blazi, M., Manev, H., Sverko, V., Gabrilovac, J., Radacic, M., Pivac, N., and Miljenovic, G. (1990) Immune response of stressed rats treated with drugs affecting serotoninergic and adrenergic transmission, Biomed. & Pharmacother. 44, 381–387.
Jackson, J.C., Cross, R.J., Walker, R.F., Markesbery, W.R., Brooks, W.H., and Roszman, T.L. (1985) Influence of serotonin on the immune response, Immunology 54, 505–512.
Devoino, L., Morozova, N., and Cheido, M. (1988) Participation of serotoninergic system in neuroimmunomodulation: intraimmune mechanisms and the pathways providing an inhibitory effect, Int. J. Neurosci. 40, 111–128.
Slauson, D.O., Walker, C., Kristensen, F., Wang, Y., and de Weck, A.L. (1984) Mechanisms of serotonin-induced lymphocyte proliferation inhibition, Cell. Immunol. 1984, 84, 240–252.
Silverman, D.H.S., Wu, H., and Karnovsky, M.L. (1985) Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide releaseBiochem. Biophys. Res. Com. 131 (3), 1160–1167.
Silverman, D.H.S., Krueger, J.M., and Karnovsky, M.L. (1986) Specific binding sites for muramyl peptides on murine macrophages, J. Immunol. 136, 2195–2198.
Bonnet, M., Lespinats, G., and Burtin, C. (1987) Evidence for serotonin (5HT) binding sites on murine lymphocytes. Int. J. Immunopharmac. 9, 551–556.
Van Loveren, H., Den Otter, W., Meade, R., Terheggen, P.M.A.B., and Askenase, P.W. (1985) A role for mast cells and the vasoactive amine serotonin in T cell-dependent immunity to tumors, J. Immunol. 134 (2), 1292–1299.
Choquet, D. and Korn, H. (1988) ‘Dual effects of serotonin on a voltage-gated conductance in lymphocytes’, Proc. Nat. Acad. Sci. 85, 4557–4561.
Hellstrand, K. and Hermodsson, S. (1987) ‘Role of serotonin in the regulation of human natural killer cell cytotoxicity’, J. Immunol. 139 (3), 869–875.
Hellstrand, K. and Hermodsson, S. (1990) Monocyte-mediated suppression of IL-2-induced NK-cell activation. Regulation by 5-HT1A-type serotonin receptors, Scand. J. Immunol. 32, 183–192.
Fuller, R. (1992) ‘The involvement of serotonine in regulation of pituitary adreno-cortical function, Frontiers in Neuroendocrin. 3, 250–270.
Carlson, S.L., Felten, D.L., Livnat, S., and Felten, S.Y. (1987) Alterations of monoamines in specific central autonomic nuclei following immunization in mice, Brain, Behavior, and Immunity 1, 52–63.
Gemma, C., Ghezzi, P., and De Simoni, M.G. (1991) Activation of the hypothalamic serotoninergic system by central interleukin-1, Eur. J. Pharmacology 209, 139–140.
Bonnet, M., Lespinats, G., and Burtin, C. (1984) Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells, Cellular Immunology 83, 280–291.
Boyum, A. (1968) Isolation of mononuclear cells and granulocytes, Scan. J. Clin. Lab. Invest. 21 (Suppl.), 77–99.
Lorens, A.S., Hata, N., Handa, R.J., Van de Kar, L.D., Guschwan, M., Goral, J., Lee, M.J., Hamilton, M.E., Bethea, C.L., and Clancy Jr., J. (1990) Neurochemical, endocrine and immunological responses to stress in young and old fischer 344 male rats, Neurobiol. Aging 11, 139–150.
Haour, F., Ban, E., Milon, G., Baran, D., and Fillion, G. (1990) Brain interleukin-1 receptors: characterization and modulation after lipopolysaccharide injection, Progress in NeuroEndocrinImmunology 3(3), 1–4.
Ban, E., Milon, G., Prudhomme, N., Fillion, G., and Haour, F. (1991) Receptors for interleukin-1 (a and ß) in mouse brain: mapping and neuronal localization in hippocampus, Neuroscience 43, 21–31.
Cunningham, E.T., Jr., Wada, E., Carter, D.B., Tracey, D.E., Battey, J.F., and De Souza, E.B. (1992) In situ histochemical localization of Type I Interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse, J. Neurosci. 12 (3), 1101–1114.
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© 1993 Springer Science+Business Media Dordrecht
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Fillion, G., Fillion, MP., Cloez-Tayarani, I., Sarhan, H., Haour, F., Bolanos, F. (1993). 5-HT And The Immune System. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_38
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DOI: https://doi.org/10.1007/978-94-011-1920-7_38
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