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Abnormal Coronary Vasoconstrictor Responses to Serotonin in Patients with Ischemic Heart Disease

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Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

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Abstract

The coronary vasomotor responses to acetylcholine, serotonin (5-HT) and to isosorbide dinitrate were assessed by quantitative coronary arteriography in 31 patients.

Acetylcholine induced constrictions in diseased coronary arteries (n=15). In the patients with smooth normal coronary arteriograms, acetylcholine caused dilatations in 7 patients (smooth dilators) and constrictions in 9 patients (smooth constrictors). 5-HT evoked no significant diameter changes in the smooth dilators (+1.4 ± 4.1%), but in the smooth constrictors and in the patients with diseased coronary arteries 5-HT caused potent constrictions. The vasoconstrictor responses to 5-HT were similar in patients with minimal (-26.5 ± 4.7%) and with advanced atherosclerosis (-30.9 ± 5.3%). Isosorbide dinitrate reversed rapidly the vasoconstriction induced by 5-HT.

Both in early and advanced atherosclerosis, impairment of endothelium-dependent vasodilation causes a hypersensitivity of the coronary artery to the vasoconstrictor stimulus of 5-HT.

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Author information

Authors and Affiliations

  1. Department of Cardiology, University Hospital of Antwerp(UTA), Wilrijkstraat 10, Edegem, 2590, Belgium

    C. J. Vrints, J. Bosmans & J. P. Snoeck

  2. Division of Pharmacology, University of Antwerp (UTA), Wilrijkstraat 10, Edegem, 2590, Belgium

    H. Bult & A. G. Herman

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  1. C. J. Vrints
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  2. J. Bosmans
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  3. H. Bult
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  4. A. G. Herman
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  5. J. P. Snoeck
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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© 1993 Springer Science+Business Media Dordrecht

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Vrints, C.J., Bosmans, J., Bult, H., Herman, A.G., Snoeck, J.P. (1993). Abnormal Coronary Vasoconstrictor Responses to Serotonin in Patients with Ischemic Heart Disease. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_37

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  • DOI: https://doi.org/10.1007/978-94-011-1920-7_37

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

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