Skip to main content
SpringerLink
Log in

Preclinical Evidence for the Role of Serotonin Receptors in Anxiety

  • Chapter
  • First Online:
Book cover Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

Abstract

Animal paradigms are important to detect anxiolytic properties of psychoactive compounds. Two animal anxiety paradigms are presented, ultrasonic distress vocalizations (USV) in rat pups and stress-induced hyperthermia (SIH) in mice, to describe the putative anxiolytic properties of serotonergic ligands. Both paradigms indicate that 5-HTAreceptor agonists are potent anxiolytics, whereas specific 5-HT reuptake blockers also exert some anxiolytic properties. 5-HT02antagonists may have some anxiogenic properties (in USV), whereas 5-HT, antagonists seem to be devoid of anxiolytic properties in the paradigms used.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Van der Poel, A.M., Molewijk, E., MosJ.and Olivier, B. (1991) ‘Is clonidine anxiogenic in rat pups?’, in B. Olivier, J. Mos and J.L. Slangen (eds.), Animal models in Psychopharmacology, Birkhäuser Verlag, Basel, pp. 107–116.

    Chapter  Google Scholar 

  2. Miczek, K.A., Tornatzky, W., and Vivian, J. (1991) ‘Ethology and neuropharmacology: rodent ultrasounds’, in B. Olivier, J. Mos and J.L. Slangen (eds.), Animal models in Psychopharmacology, Birkhäuser Verlag, Basel, pp. 409–427.

    Chapter  Google Scholar 

  3. Insel, T.R. and Winslow, J.T. (1991) ‘Rat pup ultrasonic vocalizations: an ethologically relevant behavior responsive to anxiolytics’, in B. Olivier, J. Mos and J.L. Slangen (eds.) Animal models in Psychopharmacology, Birkhäuser Verlag, Basel, pp. 15–36.

    Chapter  Google Scholar 

  4. Mos, J. and Olivier, B. (1988) ‘Ultrasonic vocalizations by rat pups as an animal model for anxiolytic activity: effects of antidepressants’, in B. Olivier and J. Mos (eds.), Depression, Anxiety and Aggression, Preclinical and clinical interfaces, Medidact, Houten, pp. 85–93.

    Google Scholar 

  5. Mos, J. and Olivier, B. (1989) ‘Ultrasonic vocalizations by rat pups as an animal model for anxiolytic activity: effects of serotonergic drugs’, in P. Bevan, A.R. Cools and T. Archer (eds.), Behavioral Pharmacology of 5-HT, Lawrence Erlbaum, New Jersey, pp. 361–366.

    Google Scholar 

  6. Olivier, B., Tulp, M.Th.M., and Mos, J. (1991) ‘Serotonergic receptors in anxiety and aggression; evidence from animal pharmacology’, Human Psychopharmacology 6, S72–S78.

    Article  Google Scholar 

  7. Kehne, J.H., McCloskey, T.C., Baron, B.M., Chi, E.M., Harrison, B.L., Whitten, J.P., and Palfreyman, M.G. (1991) ‘NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations’, Eur. J. Pharmacol. 193, 283–292.

    Article  CAS  Google Scholar 

  8. Winslow, J.T. and Insel, T.R. (1991) ‘Serotonergic modulation of the rat pup ultrasonic isolation call: studies with 5-HT, and 5-HT, subtype-selective agonists and antagonists’, Psychopharmacology 105, 513–520.

    Article  CAS  Google Scholar 

  9. Nastiti, K., Benton, D., Brain, P.F., and Haug, M. (1991) ‘The effects of 5-HT receptor ligands on ultrasonic calling in mouse pups’, Neurosci. Biobehay. Rev. 15, 483–487.

    Article  CAS  Google Scholar 

  10. Winslow, J.T. and Insel, T.R. (1990) ‘Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rats pups’, Neuropsychopharmacology 3, 51–59.

    PubMed  CAS  Google Scholar 

  11. Borsini, F., Lecci, A., Volterra, G., and Meli, A. (1989) ‘A model to measure anticipatory anxiety in mice?’, Psychopharmacology 98, 207–211.

    Article  CAS  Google Scholar 

  12. Lecci, A., Borsini, F., Mancinelli, A., D’Arranno, V., Stasi, M.A., Volterra, G., and Meli, A. (1990) ‘Effects of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice’, J. Neural Transm. 82, 219–230.

    Article  CAS  Google Scholar 

  13. Lecci, A., Borsini, F., Volterra, G., and Meli, A. (1990) ‘Pharmacological validation of a novel animal model of anticipatory anxiety in mice’, Psychopharmacology 101, 255–261.

    Article  CAS  Google Scholar 

  14. Zethof, T.J.J., Van de Heyden, J.A.M., and Olivier, B. (1991) ‘A new animal model for anticipatory anxiety?’, in B. Olivier, J. Mos and J.L. Slangen (eds.) Animal models in Psychopharmacology, Birkhäuser Verlag, Basel, pp. 65–68.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of CNS pharmacology, Solvay Duphar B.V., P.O. Box 900, Weesp, 1380, DA, The Netherlands

    Jan Mos, Ellen Molewijk, Theo Zethof & Guus Van Der Poel

  2. Department of Psychopharmacology Faculty of Pharmacy, State University, Utrecht, The Netherlands

    Berend Olivier

Authors
  1. Berend Olivier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan Mos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ellen Molewijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Theo Zethof
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guus Van Der Poel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Olivier, B., Mos, J., Molewijk, E., Zethof, T., Van Der Poel, G. (1993). Preclinical Evidence for the Role of Serotonin Receptors in Anxiety. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_24

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1920-7_24

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation