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Serotonin pp 179–186Cite as

Serotonin and Serotonergic Drugs in Emesis

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Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

Abstract

The involvement of the major subtypes of 5-HT receptor in emesis is briefly reviewed; 5-HT,, receptors have been implicated particularly in motion sickness, although evidence is emerging for a more generalized involvement in other types (e.g. copper sulphate, cisplatin); 5-HT, receptors may be involved in apomorphine and copper sulphate emesis but further studies are required; 5-HT, receptor antagonists are the most extensively studied and are in clinical use for the treatment of emesis induced by intragastric copper sulphate.

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References

  1. Miner, W.D. and Sanger, G.J. (1986) ‘Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism’, Br. J. Pharmacol. 88, 497–499.

    Article  CAS  Google Scholar 

  2. Lucot, J.B. and Crampton, G.H. (1986) ‘Xylazine emesis, yohimbine and motion sickness susceptibility in the cat’, J. Pharm. Exp. Ther. 237, 450–455.

    CAS  Google Scholar 

  3. Lucot, J.B. (1992) ‘Prevention of motion sickness by 5-HT,A agonists in cats’, in A. Bianchi, L. Grelot, A.D. Miller and G.L. King (eds.), Mechanisms and control of emesis, Colloque INSERM, John Libbey, Eurotext 223, 195–201.

    CAS  Google Scholar 

  4. Lucot, J.B. (1990) ‘Effects of serotonin antagonists on motion sickness and its suppression by 8-OH-DPAT in cats’, Pharmacol. Biochem. Behay. 37, 283–287.

    Article  CAS  Google Scholar 

  5. Lucot, J.B. and Crampton, G.H. (1987) ‘Buspirone blocks cisplatin-induced emesis in cats’, J. Clin. Pharmacol. 27, 817–818.

    Article  CAS  Google Scholar 

  6. Lucot, J.B. (1990) ‘RU 24969-induced emesis in the cat: 5-HT1 sites other than 5-HT,A, 5-HT,, 5-HT,c implicated’, Eur. J. Pharmacol. 180, 193–199.

    Article  CAS  Google Scholar 

  7. Andrews, P.L.R. and Davis, C.J. (1993) ‘The mechanism of emesis induced by anti-cancer therapies’, in P.L.R. Andrews and G.J. Sanger (eds.), Emesis in anti-cancer therapy, mechanisms and treatment, Chapman and Hall Medical, London, p. 113–162.

    Google Scholar 

  8. Milano, S. and Grelot, L. (1992) ‘Differential Blocking effects of buspirone and 8-OH-DPAT on vagal-induced emesis in decerebrate cats’, in A. Bianchi, L. Grelot, A.D. Miller and G.L. King (eds.), Mechanisms and control of emesis, Colloque INSERM, John Libbey, Eurotext 223, 353–355.

    Google Scholar 

  9. Lang, I.M. and Marvig, J. (1989) ‘Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting’, Am. J. Physiol. 256, G92–G99.

    PubMed  CAS  Google Scholar 

  10. Schwörer, H., Racke, K., and Kilbinger, H. (1991) ‘Cisplatin increases the release of 5-hydroxytryptamine (5-HT) from the isolated vascularly perfused small intestine of the guinea pig: Involvement of 5-HT3 receptors’, Naunyn Schmeidebergs Arch. Pharmacol. 344, 143–149.

    Google Scholar 

  11. Andrews, P.L.R., Bhandari, P., and Davis, C.J. (1992) ‘Plasticity and modulation of the emetic reflex’, in A.L. Bianchi, L. Grelot, A.D. Miller and G.L. King (eds.), Mechanisms and control of emesis, Colloque INSERM, John Libbey, Eurotext 223, p. 275–284.

    Google Scholar 

  12. Andrews, P.L.R. and Bhandari, P. (1993) ‘The 5-hydroxytryptamine3 receptor antagonists as antiemetics: preclinical evaluation and mechanism of action’, Eur. J. Cancer 29A, S11–S16.

    Article  CAS  Google Scholar 

  13. Ravenscroft, M., Wells, U., Bhandari, P.B., and Andrews, P.L.R. (1992) ‘Agonist evidence for the involvement of 5-HT3 receptors in emesis in the ferret’, in A.L. Bianchi, L. Grelot, A.D. Miller and G.L. King (eds.), Mechanisms and control of emesis, Colloque INSERM, John Libbey, Eurotext 223, p. 251–252.

    Google Scholar 

  14. Andrews, P.L.R. and Lawes, I.N.C. (1992) ‘A protective role for vagal afferents hypothesis’, in S. Ritter, R.C. Ritter and C.D. Barnes (eds.), Neuroanatomy and Physiology of Abdominal vagal afferents, CRC Press, Boca Raton, Florida, p. 280–301.

    Google Scholar 

  15. Pratt, G.D., Bowery, N.G., Kilpatrick, G.J., Leslie, R.A., Barnes, N.M., Naylor, R.J., Jones, B.J., Nelson, D.R., Palacios, J.M., Slater, P., and Reynolds, D.J.M. (1990) ‘Consensus meeting agrees distribution of 5-HT3 receptors in mammalian hindbrain’, Trends Pharmacol. Sci. 11, 135–137.

    CAS  Google Scholar 

  16. Eglen, R.M., Alvarez, R., Johnson, L.G., Leung, L.G., and Wong, E.H.F. (1993) ‘The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT,) receptors’, Br. J. Pharmacol. 108, 376–382.

    Article  CAS  Google Scholar 

  17. Bhandari, P. and Andrews, P.L.R. (1991) ‘Preliminary evidence for the involvement of the putative 5-hydroxytryptamine, receptor in zacopride and copper sulphate-induced vomiting in the ferret’, Eur. J. Pharmacol. 204, 273–280.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology St, George’s Hospital Medical School Cranmer Terrace London SW17, ORE, UK

    U. Wells, M. Ravenscroft, P. Bhandari & P. L. R Andrews

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  1. U. Wells
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  2. M. Ravenscroft
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  3. P. Bhandari
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  4. P. L. R Andrews
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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© 1993 Springer Science+Business Media Dordrecht

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Wells, U., Ravenscroft, M., Bhandari, P., Andrews, P.L.R. (1993). Serotonin and Serotonergic Drugs in Emesis. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_21

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  • DOI: https://doi.org/10.1007/978-94-011-1920-7_21

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

  • eBook Packages: Springer Book Archive

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