Abstract
The CNS-mediated hypotensive response to urapidil is attributed to 5-HT1A receptor stimulation in anesthetized cats. This effect significantly participates in the blood pressure reduction following peripheral drug administration besides inhibition of vascular αl-adrenoceptors. In conscious dogs, the a1-antagonist effect prevents the appearance of a 5-HT syndrome, which is seen after ‘pure’ S-HT1A agonists, and contributes to the good tolerability of urapidil. It is concluded that the well-balanced properties of the hybrid molecule of urapidil make it an efficient and well-tolerable antihypertensive drug.
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Kolassa, N., Beller, K.D., Boer, R., Boss, H., Sanders, K.H. (1993). Urapidil: The Role of 5-HT1A and α-Adrenergic Receptors in Blood Pressure Reduction. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_17
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