Abstract
The promoter of human monoamine oxidase (MAO) A and B genes have been identified. The MAO A promoter activity is located in a 0.24 kb PvuII/DraII fragment containing two 90 bp repeats, each of which contains two Spl elements and lacks a TATA box. The highest MAO B promoter activity is detected in a 0.15 kb PstI/NaeI fragment which contains a Spl-CACCC-Spl-TATA structure. The different organization of the MAO A and B promoters may underlie their different cell and tissue specific expression.
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References
Chiba, K., Trevor, A., and Castagnoli, N. (1984) ‘Metabolism of the neurotoxic tertiary amine, MPTP by brain monoamine oxidase’, Biochem. Biophys. Res. Commun. 120, 574–578.
Bach, A.W.J., Lan, N.C., Johnson, D.L., Abell, C.W., Bembenek, M.E., Kwan, S.-W., Seeberg, P.H., and Shih, J.C. (1988) ‘cDNA cloning of human monoamine oxidase A and B: molecular basis of differences in enzymatic properties’, Proc. Natl. Acad. Sci. USA 85, 4934–4938.
Hsu, Y.P., Weyler, W., Chen, S., Sims, K.B., Rinehart, W.B., Utterback, M., Powell, J.F., and Breakefield, X.O. (1988) ‘Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences’, J. Neurochem. 51, 1321–1324.
Lan, N.C., Chen, C.H., and Shih, J.C. (1989) ‘Expression of functional human monoamine oxidase (MAO) A and B cDNA in mammalian cells’, J. Neurochem. 52, 1652–1654.
Shih, J.C. (1990) ‘Molecular basis of human MAO A and B’ Neuropsychopharmacology 4, 1–7.
Grimsby, J., Chen, K., Wang, L.J., Lan, N.C. and Shih, J.C. (1991) ‘Human monoamine oxidase A and B genes exhibit identical exon-intron organization’, Proc. Natl. Acad. Sci. USA 88, 3637–3641.
Ozelius, L., Hsu, Y.P., Bruns, G., Powell, J.F., Chen, S., Weyler, W., Utterback, M., Zucker, D., Haines, J., Trofalter, J.A., Conneally, P.M., Gusella, J.F., and Breakefield, X.O. (1988) ‘Human monoamine oxidase gene (MAOA): Chromosome position (Xp21-p11) and DNA polymorphism’, Genomics 3, 53–58.
Lan, N.C., Heinzmann, C., Gal, A., Klisak, I., Orth, U., Lai, E., Grimsby, J., Sparkes, R.S., Mohandas, T., and Shih, J.C. (1989) ‘Human monoamine oxidase A and B genes map to Xp11.23 and are deleted in a patient with Norris Desease’, Genomics 4, 552–55.
Grimsby, J., Lan, C., Neve, R., Chen, K., and Shih, J.C. (1990) ‘Tissue distribution of human MAO A and B mRNA’, J. Neurochem. 55, 1166–1169.
Chen, S., Shih, J.C., and Xu, Q.P. (1984) ‘Interaction of N-(2-nitro-4- azidophenyl) serotonin with two types of monoamine oxidase in rat brain’, J. Neurochem. 43, 1680–1687.
Zhu, Q.S., Grimsby, J., Chen, K., and Shih, J.C. (1992) ‘Promoter organization and activity of human monoamine oxidase (MAO) A and B genes’, J. Neuroscience, in press.
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© 1993 Springer Science+Business Media Dordrecht
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Shih, J.C., Zhu, QS., Grimsby, J., Chen, K., Shih, J. (1993). Different Organization of Human Monoamine Oxidase (Mao) A and B Promoters. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_1
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DOI: https://doi.org/10.1007/978-94-011-1920-7_1
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