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Neurohumoral Regulation of Coronary Flow pp 73–88Cite as

Positron Emission Tomography and the Detection of Endothelial Dysfunction

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 150))

Abstract

Endothelial dysfunction is generally studied in patients with atherosclerosis in the context of the dilator response of epicardial coronary arteries to acetylcholine1–4, phenylephrine1 or cold pressor test2–4. In the clinical situation this dilator response is or can be measured directly or indirectly in different invasive ways: a) quantitative coronary angiography2, b) continuous coronary sinus ther-modilution3, c) injection of radioactive xenon (133Xe) into the coronary vessel4, d) doppler flow measurements into the coronary vessel5, e) continuous measurement of the argon concentration after inhalation in the arterial and the coronary sinus blood6, and f) intravascular ultrasound cross-sectional arterial imaging7. However, not only some serious theoretical and practical drawbacks have been described8, but also these invasive methods do not allow determination of regional changes, inclusion of a control group of healthy volunteers, or to perform multiple studies in a single patient. Furthermore, the progression of disease and the influence of therapy cannot be evaluated. The only non-invasive method for measuring regional myocardial blood perfusion is positron emission tomography (PET). Although it is a rather complicated and expensive method, its applicability is better than other methods. Its quantitative capabilities permit not only an impression of regional perfusion differences, but also absolute measurements9.

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Authors
  1. J. G. Meeder MD
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  2. P. K. Blanksma MD
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  3. R. L. Anthonio MD
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  4. A. T. M. Willemsen MD
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  5. J. Pruim MD
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University Hospital Groningen, Groningen, The Netherlands

    W. H. van Gilst

  2. Department of Cardiology Thorax-Center, University Hospital Groningen, Groningen, The Netherlands

    K. I. Lie

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© 1993 Springer Science+Business Media Dordrecht

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Meeder, J.G., Blanksma, P.K., Anthonio, R.L., Willemsen, A.T.M., Pruim, J. (1993). Positron Emission Tomography and the Detection of Endothelial Dysfunction. In: van Gilst, W.H., Lie, K.I. (eds) Neurohumoral Regulation of Coronary Flow. Developments in Cardiovascular Medicine, vol 150. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1900-9_6

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  • DOI: https://doi.org/10.1007/978-94-011-1900-9_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4839-2

  • Online ISBN: 978-94-011-1900-9

  • eBook Packages: Springer Book Archive

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