Abstract
The relationship between molecular structure of the visual pigment genes and red-green color vision was studied in 126 normal and 63 color-defective males. We found that the great majority of defects in red-green color vision are associated with the formation of 5′R-G hybrid genes (protan series), deletion of the G gene (deutan series), or the formation of 5′R-G hybrid genes (deutan series). Within these two series, however, dichromacy and trichromacy cannot always be predicted from the molecular patterns, particularly among protans. Amino acid residues in exon 5 largely determine whether a hybrid gene will be more R-like or more G-like in phenotype. We observed numerous genetic polymorphisms in the R and G pigment genes of both normal and color-defective subjects. These polymorphisms may account for some, but not all, of the observed variations in color vision phenotypes. A common Ser/Ala polymorphism at position 180 of the R pigment gene was found to be highly correlated with the bimodal distribution of Raleigh matches we observed among 50 color-normal Caucasian males.
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© 1993 Springer Science+Business Media Dordrecht
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Deeb, S.S. et al. (1993). Structure-function relationships in human red/green color vision. In: Drum, B. (eds) Colour Vision Deficiencies XI. Documenta Ophthalmologica Proceedings Series, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1856-9_2
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DOI: https://doi.org/10.1007/978-94-011-1856-9_2
Publisher Name: Springer, Dordrecht
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