Abstract
In an effort to separate metabolic from structural bases for the early S (short-wavelength) pathway sensitivity losses, we explored the relationship between acute changes in blood glucose and S sensitivity in diabetes. S and ML (middle/long wavelength) sensitivities were assessed by measuring thresholds for 1.5° blue and yellow targets, respectively, presented on 200 cd/m2 yellow backgrounds. Induced and endogenous variations in blood glucose are accompanied by variations in S, but not ML sensitivity, such that relatively higher S sensitivities are associated with relatively lower blood glucose levels. This association is consistent with a metabolic basis for the steady-state S sensitivity loss often reported in diabetic eyes without retinopathy. Possible mechanisms of the acute glucose-dependent S sensitivity loss considered are transient hypoxia, reductions in neurotransmitters, and changes in the refractive index of the outer segments leading to decreased light-absorbing capabilities of the photoreceptors.
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© 1993 Springer Science+Business Media Dordrecht
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Schneck, M.E., Adams, A.J., Volbrecht, V.J., Linfoot, J.L. (1993). Acute changes in blood glucose and their effects on color vision function in diabetes. In: Drum, B. (eds) Colour Vision Deficiencies XI. Documenta Ophthalmologica Proceedings Series, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1856-9_18
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DOI: https://doi.org/10.1007/978-94-011-1856-9_18
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