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Calcium and the Production of Endothelium-Derived Vasoactive Factors

  • Chapter
Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

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Abstract

Endothelial cells play a major role in the local control of the vascular system. They form a semipermeable barrier which regulates the exchange of nutrients and waste products between the blood and the underlying smooth muscle. These cells also influence the tone of the blood vessel wall, in part, by releasing potent and short-lasting relaxing factors such as prostanoids, nitric oxide and endothelium-derived hyperpolarizing factor, as well as contractile factors such as thromboxane/endoperoxides, superoxide anions, and endothelin(s). The present review will discuss the biological properties of the vasoactive factors and emphasize the importance of calcium ions for both the production of the factors by the endothelial cells and the modulation of the vascular tone that they achieve.

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Author information

Author notes

  1. T. Nagao

    Present address: 2nd Department of Internal Medicine, Kyushu University, Maidash 3-1-1 Highashi-ku, Fukuoka 812, Japan

Authors and Affiliations

  1. Center for Experimental Therapeutics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    V. B. Schini, T. Nagao, S. Illiano & P. M. Vanhoutte

Authors
  1. V. B. Schini
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  2. T. Nagao
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  3. S. Illiano
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  4. P. M. Vanhoutte
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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© 1993 Springer Science+Business Media Dordrecht

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Schini, V.B., Nagao, T., Illiano, S., Vanhoutte, P.M. (1993). Calcium and the Production of Endothelium-Derived Vasoactive Factors. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_5

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4756-2

  • Online ISBN: 978-94-011-1725-8

  • eBook Packages: Springer Book Archive

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