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A New Class of Calcium Antagonist Selective for the GI Tract

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Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

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Abstract

This article is aimed at providing evidence in support of the existence of a new class of Ca2+ antagonist, the prototype being pinaverium bromide, which exhibits selectivity for the gastrointestinal (GI) tract. It should be recalled that Ca2+ is implicated at different levels in the functions of the GI tract. As examples, Ca2+ plays roles in excitation-contraction coupling in smooth muscle of the esophagus, stomach, and intestine, it is involved in the regulation of blood flow (alterations of which could be related to the formation of ulcers), and Ca2+ overload can lead to hepatocellular injuries. Aspects related to GI motility will be emphasized herein.

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Author information

Authors and Affiliations

  1. SOLVAY PHARMA, Laboratoires de Thérapeutique Moderne (L.T.M.), 42, rue Rouget-de-Lisle, B.P. 22, 92151, Suresnes Cedex, France

    M. O. Christen

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  1. M. O. Christen
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Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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© 1993 Springer Science+Business Media Dordrecht

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Christen, M.O. (1993). A New Class of Calcium Antagonist Selective for the GI Tract. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_43

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_43

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4756-2

  • Online ISBN: 978-94-011-1725-8

  • eBook Packages: Springer Book Archive

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