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Pharmacological Basis for use of Calcium Antagonists in Dementia

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Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

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Abstract

Calcium overload is thought to be one of the processes contributing to neuronal death. Pathological enhancement of calcium transients can lead to disruption of cytoskeletal and membrane structures, adversely altering cellular function (1). Cytosolic free calcium increases in ischemic brain (2) and certain neurotoxins are known to elevate cytosolic calcium prior to the death of neurones (3,4).

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References

  1. Siesjö B.K. (1990): Eur. J. Neurol., 30: (suppl.2): 3–9.

    Article  Google Scholar 

  2. Uematsu D., Greenberg J.H., Hickey W.F. and Reivich M. (1989): Stroke, 20:1531–1537.

    Article  PubMed  CAS  Google Scholar 

  3. Sucher N.J., Lei S.Z. and Lipton S.A. (1991): Brain Res., 297: 297–302.

    Article  Google Scholar 

  4. Dreyer E.B., Kaiser P.K., Offermann J.T. and Lipton S.A. (1990): Science, 248: 364–367.

    Article  PubMed  CAS  Google Scholar 

  5. Kazda S., Garthoff B., Krause H.P. and Schlossmann K. (1982): Arzneimittelforsch, 32: 331–338.

    PubMed  CAS  Google Scholar 

  6. Hoffmeister F., Benz U., Heise A., Krause H.P. and Neuser V. (1982): Arzneimittelforsch, 32: 347–360.

    PubMed  CAS  Google Scholar 

  7. Towart R. (1981): Circ. Res., 48: 650–657.

    Article  PubMed  CAS  Google Scholar 

  8. Bellemann P., Schade A. and Towart R. (1983): Proc. Natl Acad. Sci USA, 80: 2356–2360.

    Article  PubMed  CAS  Google Scholar 

  9. Quirion R. (1986): Eur. J. Pharmacol, 117: 139–142.

    Article  Google Scholar 

  10. McCarthy R.T. and TanPiengco P.E. (1991): .J. Neurosci., (submitted).

    Google Scholar 

  11. Chisholm J.: personal communication.

    Google Scholar 

  12. Fahey J.M., Hedayat B., Cook J.R., Isaacson R.L. and Van Buskirk R.G. (1989): In: Nimodipine and Central Nervous System Function: New Vistas, edited by J. Traber and W.H. Gispen pp. 117–40. Schattauer, Stuttgart.

    Google Scholar 

  13. Azmitia E.C. (1989): In: Nimodipine and Central Nervous System Function: New Vistas, edited by J. Traber and W.H. Gispen pp. 141–159. Schattauer, Stuttgart.

    Google Scholar 

  14. Weiss J.H. and Choi D.W. (1991): In: Nimodipine, Pharmacological and Clinical Results in Cerebral Ischemia, edited by A. Scriabine, G.M. Teasdale, D.Tettenborn and W. Young pp. 57–63. Springer, Berlin.

    Google Scholar 

  15. LeVere T.E., Brugler T., Sandin M. and Gray-Silva S. (1989): Behav. Neurosci, 103: 561–565.

    Article  PubMed  CAS  Google Scholar 

  16. Poplawsky A. and Isaacson R.L. (1990): Behav. NeuraL Biol., 53: 133–139.

    Article  PubMed  CAS  Google Scholar 

  17. Finger S., Green L., Tarnoff M.E., Mortman K.D. and Andersen A. (1990): Exp. Neurol, 109: 279–285.

    Article  PubMed  CAS  Google Scholar 

  18. Isaacson R.L., Shen Y. and Mandel A. (1990): Rest. Neurol Neurosci., 2: 1–7.

    CAS  Google Scholar 

  19. Schuurman T., Klein H., Beneke M. and Traber J. (1987): Neurosci Res. Commun., 1: 9–15.

    CAS  Google Scholar 

  20. Luiten P.G.M., deJong G.I., Malder A.B., Horvath E., Schuurman T. and Traber J. (1989): In: Nimodipine and Central Nervous System Function: New Vistas, edited by J. Traber and W.H. Gispen pp. 239–256. Schattauer, Stuttgart.

    Google Scholar 

  21. Nyakas C., Markel E., Schuurman T. and Luiten P.G.M. (1991): Eur. J. Neurosci, 3: 168–174.

    Article  PubMed  Google Scholar 

  22. Deyo R.A., Straube K.T. and Disterhoft J.F. (1989): Science, 243: 809–811.

    Article  PubMed  CAS  Google Scholar 

  23. Sandin M., Jasmin S. and Levere T.E. (1990): Neurobiol Aging, 11: 573–575.

    Article  PubMed  CAS  Google Scholar 

  24. Tobares N., Pedromingo A. and Bigorra J. (1989): In: Diagnosis and Treatment of Senile Dementia, edited by M. Bergener and B. Reisberg pp. 360–365. Springer, Berlin.

    Book  Google Scholar 

  25. Ban T.A., Morey L., Aguglia E., Azzarelli O., Balsano F., Marigliano V., Caglieris N., Sterlicchio M., Capurso A., Tomasi N.A., Crepaldi, G., Volpe D., Palmieri G., Ambrosi G., Polli E., Cortellaro M., Zanussi C. and Froldi M. (1990): Prog. Neuropsychopharmacol Biol. Psychiat., 14: 525–551.

    Article  CAS  Google Scholar 

  26. Tollefson G.D. (1990): BioL Psychiat., 27: 1133–1142.

    Article  PubMed  CAS  Google Scholar 

  27. Scriabine A., Schuurman T. and Traber J. (1989): FASEB J., 3: 1799–1806.

    PubMed  CAS  Google Scholar 

  28. Bär P.R., Traber J., Schuurman T. and Gispen W.H. (1991): J. Neural. Transm. (suppl.)31: 55–71.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Miles Inc., 400 Morgan Lane, West Haven, Connecticut, 06516, USA

    Alexander Scriabine

Authors
  1. Alexander Scriabine
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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© 1993 Springer Science+Business Media Dordrecht

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Scriabine, A. (1993). Pharmacological Basis for use of Calcium Antagonists in Dementia. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_38

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4756-2

  • Online ISBN: 978-94-011-1725-8

  • eBook Packages: Springer Book Archive

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