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Effect of Aging on Brain Voltage-Dependent Calcium Channels

  • Chapter
Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

Abstract

Control of interneuronal communication involves a variety of homeostatic mechanisms in which free calcium ions play a fundamental role (1). An altered metabolism of calcium in the brain that occurs with aging has been observed since the beginning of this century (2). A number of data have been accumulated mostly in the last decade, indicating that aging modifies a number of functions that are strictly related to, and controlled by, calcium ions (3). Release processes, enzymatic activities, and neuronal plasticity are all impaired as a consequence of age, so that a unifying model of brain aging stressing the importance of this ion has been proposed (4).

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Author information

Authors and Affiliations

  1. Department Experimental Medicine and Biochemical Sciences, II University of Roma, Rome, Italy

    Fiorenzo Battaini & Marco Trabucchi

  2. Institute of Physiology, Georgian Academy of Science, Tbilisi, Georgia

    Valerian Chikvaidze

  3. Pharmacobiology Department, University of Bari, Bari, Italy

    Stefano Govoni

Authors
  1. Fiorenzo Battaini
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  2. Marco Trabucchi
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  3. Valerian Chikvaidze
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  4. Stefano Govoni
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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© 1993 Springer Science+Business Media Dordrecht

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Battaini, F., Trabucchi, M., Chikvaidze, V., Govoni, S. (1993). Effect of Aging on Brain Voltage-Dependent Calcium Channels. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_32

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_32

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4756-2

  • Online ISBN: 978-94-011-1725-8

  • eBook Packages: Springer Book Archive

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