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Myocardial preservation in the immature heart

  • Chapter
Ischemia-reperfusion in cardiac surgery

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 142))

Abstract

The repair of most congenital intra-cardiac defects in neonates and infants requires a period of myocardial ischemia to provide satisfactory operating conditions for the conduct of the repair. Extensive efforts have been made to improve the preservation of the heart during these periods of surgically induced ischemia, but there is still a need for further improvements in this area. The majority of the experimental efforts have involved ‘mature’ heart models, but there are reasons to believe that myocardial ischemia may have different effects on the ‘immature’ heart from the ‘mature’ heart. Therefore different strategies for myocardial preservation might be desirable for the immature heart. This discussion will focus primarily on preservation of the ‘immature’ heart although it must be understood that the precise definition of the term ‘immature’ remains unclear. Further, the crossover point from ‘immature’ to ‘mature’ for the human species is unknown as well.

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Authors
  1. John E. Mayer Jr.
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Editors and Affiliations

  1. Institute of Physiology, Heinrich-Heine-University, Düsseldorf, Germany

    Hans Michael Piper

  2. Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-University, Düsseldorf, Germany

    Claus J. Preusse

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© 1993 Springer Science+Business Media Dordrecht

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Mayer, J.E. (1993). Myocardial preservation in the immature heart. In: Piper, H.M., Preusse, C.J. (eds) Ischemia-reperfusion in cardiac surgery. Developments in Cardiovascular Medicine, vol 142. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1713-5_12

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  • DOI: https://doi.org/10.1007/978-94-011-1713-5_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4750-0

  • Online ISBN: 978-94-011-1713-5

  • eBook Packages: Springer Book Archive

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