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Oxidatively Modified LDL and Atherosclerosis

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Drugs Affecting Lipid Metabolism

Part of the book series: Medical Science Symposia Series ((MSSS,volume 2))

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Abstract

A growing body of evidence indicates that oxidative modification of LDL enhances its potential atherogenicity in a number of different ways. It has also been clearly demonstrated that oxidative modification does occur in vivo and that administration of some antioxidant compounds slows the progression of atherosclerosis in LDL receptor-deficient rabbits and in cholesterol-fed rabbits. Whether the antiathero-sclerotic effect of these compounds is limited to their ability to directly protect LDL against oxidation or whether they have significant additional biological effects is not clear. Recent studies on the mechanisms that may be involved in cell-catalyzed oxidation of LDL are reviewed and discussed. Finally, the pros and cons of undertaking clinical testing of the oxidative modification hypothesis are presented.

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Authors
  1. Daniel Steinberg M.D., Ph.D.
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Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Università di Milano, Via Balzaretti 9, I-20133, Milano, Italy

    A. L. Catapano  & Rodolfo Paoletti (Direttore) &  (Direttore)

  2. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    A. M. Gotto Jr. (Chairman) (Chairman)

  3. Department of Medicine, The Methodist Hospital, 6565 Fannin M.S. A601, Houston, TX, 77030-2797, USA

    Louis C. Smith (Professor of Experimental Medicine) (Professor of Experimental Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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Steinberg, D. (1993). Oxidatively Modified LDL and Atherosclerosis. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_8

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  • DOI: https://doi.org/10.1007/978-94-011-1703-6_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4746-3

  • Online ISBN: 978-94-011-1703-6

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