Abstract
The incidence of atherosclerotic coronary heart disease (CHD) was assessed in 4559 male partecipants of the Prospective Cardiovascular Munster (PROCAM) study, aged 40 to 64 years, over — 6 year follow-up period. In this time, 186 study partecipants developed atherosclerotic CHD (134 definite nonfatal myocardial infarctions and 52 definite atherosclerotic CHD deaths including 21 sudden cardiac deaths and 31 fatal myocardial infarctions). Univariate analysis revealed — significant association between the incidence of atherosclerotic CHD, and high density lipoprotein (HDL) cholesterol (p<0.001), which remained after adjustment for other risk factors.
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References
NIH Consensus Conference, Washington February 1992.
Assmann G., Oberwittler W., Schulte H., Schriewer H., Funke H., Epping P.H., Hauss W.H.: Pradiktion und Fruherkennung der koronaren Herzkrankheit. Internist 1980; 21:446–459.
Friedewald W.T., Levy J., Fredrickson D.S.: Estimation of the concentration of low-density-lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972;18:499–509.
Assmann G., Schulte H.: PROCAM Trial. Panscientia publishing house, Hedingen-Zurich 1986.
Assmann G., Schulte H.: Relation of High Density Lipoprotein Cholesterol and Triglycerides to Incidence of Atherosclerotic Coronary Artery Disease (The PROCAM Experience). Am. J. Cardiol. 1992; 70:733–737.
Nie N.H.: SPSSX User’s Guide. McGraw-Hill, New York. 1983.
Ray A.A.: SAS User’s Guide: Basics. Cary, NC, SAS Institute, 1982.
Assmann G., Schulte H.: Results and Conclusions of the Prospective Cardiovascular Munster (PROCAM) Study. In: Assmann G. (ed.) Lipid Metabolism Disorders and Coronary Heart Disease (completely revised second edition). MMV Medizin Verlag, Munchen, 1993 (in press).
Gordon T., Castelli W.P., Hjortland M.C., Kannel W.B., Dawber T.R.: High-density lipoprotein as — protective factor against coronary heart disease: The Framingham Study. Am. J. Med. 1977;62:707–714.
Jacobs D.R. (for Lipid Research Clinics Follow-up Study): High density lipoprotein cholesterol and coronary heart disease cardiovascular disease and all-cause mortality, abstract. Circulation 1985;72(suppl III): 185.
Watkins L.O., Neaton J.D., Phillips A.N. (for the MRFIT Research Group): High-density lipoprotein cholesterol and coronary heart disease incidence in black and white MRFIT usual care men. Am. J. Cardiol. 1986;57:538–545.
Miller N.E., Forde O.H., Thelle D.S., Mjos O.D. The Tromso Heart Study: High-density lipoprotein as — protective factor against coronary heart disease: — prospective case-control study. Lancet 1977;i:965–970.
Goldbourt U., Medalie J.H.: High-density lipoprotein cholesterol and incidence of coronary heart disease: The Israeli Ischaemic Heart Disease Study. Am. J. Epidemiol. 1979;109:296–308.
Enger S.C., Hjermann I., Foss O.P., Helgeland A., Holme I., Leren P., Norum K.R.: High-density lipoprotein cholesterol and myocardial infarction or sudden coronary death: — prospective case-control study in middle-aged men of the Oslo study. Artery 1979;5:170–181.
Shestov D.B. Results of four years of follow-up of USSR populations. In USA-USSR First Lipoprotein Symposium, Bethesda, 1982. Us Department of Health and Human Services, National Institutes of Health, Publication (NIH) 83-1966, 391-407.
Keys A., Karvonen M.J., Punsar S., Menotti A., Fidanza F., Farchi G.: HDL serum cholesterol and 24-year mortality of men in Finland. Int. J. Epidemiol. 1984;13:428–435.
Pocock S.J., Shaper A.G., Phillips A.N., Whitehead T.P.: High density lipoprotein cholesterol is not — major risk factor for ischemic heart disease in British men. Br. Med. J. 1986;292:515–519.
Frick H.M., Elo O., Haapa K., Heinonen O.P., Heinsalmi P., Helo P., Huttunen J.K., Kaitaniemi P., Koskinen P., Maenpaa H., Malkonen M., Manttari M., Norola S., Pasternack A., Pikkarainen J., Romo M., Sjoblom T., Nikkila E.A.: The Helsinki Heart Study-primary prevention trial with gemfibrozil in middle aged men with dyslipidaemia. Safety of treatment, Changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 1987; 317:1237–1245.
Manninen V., Huttunen J.K., Heinonen O.P., Tenkanen L., Frick M.H.: Relation between baseline lipid and lipoprotein values and the incidence of coronary heart disease in the Helsinki Heart Study. Am. J. Cardiol. 1989; 63:42H–47H.
Manninen V., Elo O., Frick M.H., Haapa K., Heinonen O.P., Heinsalmi P., Helo P., Huttunen J.K., Kaitaniemi P., Koskinen P., Maenpaa H., Malkonen M., Manttari M., Norola S., Pasternack A., Pikkarainen J., Romo M., Sjoblom T., Nikkila E.A.: Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. J. AMA 1988; 260:641–651.
Huttunen J.K., Manninen V., Manttari M., Koskinen P., Romo M., Tenkanen L., Heinonen O.P., Frick M.H.: The Helsinki Heart Study: Central Findings and Clinical Implications. Annals of Medicine 1991; 23: 155–159.
Hunt S.C., Hasstedt S.J., Kuida H., Stults B.M., Hopkins P.N. and Wiliams R.R.: Genetic heritability and common environmental components of resting and stressed blood pressures, lipids and body mass index in Utah pedigrees and twins. Am. J. Epidemiology 1989;129:625–638.
Christian J.G., Carmelli D., Castelli W.P., Fabsitz R., Grim C.E., Meaney F.J., Norton J.A., Reed T., Williams C.J. and Wood P.D.: High Density Lipoprotein Cholesterol. — 16 year longitudinal study in aging male twins. Arteriosclerosis 1990;10:1020–1027.
DeBacker G., Hulstaerdt F., DeMunck, Rosseneu M., Van Parijs L. and Dramaix M.: Serum lipids and apoproteins in students whose patients suffered prematurely form myocardial infarction. Am. Heart J. 1986; 112:478–484.
Pometta D., Micheli H., Suenram A., Jornot C: HDL lipids in close relatives of coronary heart disease patients. Atherosclerosis 1979;34:419–429.
Glomset J.A.: The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 1968;9:155–163.
Eisenberg S.: High Density Lipoprotein Metabolism. J. Lipid Res. 1984;25:1017–1058.
Tall A.R.: Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J. Clin. Invest. 1990;86:379–384.
Schmitz G., Bruning T., Williamson E. and Nowick G.: The role of reverse cholesterol transport and its disturbances in Tangier disease and HDL deficiency with xanthomas. Eur. Heart. J. 1990; 11(Suppl. E): 197–207.
Johnson W.J., Mahlberg F.H., Rothblat G.H., Phillips M.C.: Cholesterol transport between cells and high density lipoproteins. Biochim. Biophys. Acta 1991;1085:273–298.
Oram J.: Cholesterol traffiking in cells. Curr. Opin. Lipidol. 1990;1:416–421.
Ailhaud G.: Cellular signal transductans: — new role for HDL. Curr. Opin. Lipidol. 1992;2:222–226.
Castro G.R. and Fielding C.J.: Early incorporation of cell-derived cholesterol into pre-P-migrating high density lipoprotein. Biochemistry 1988;27:25–29.
Huang Y., von Eckardstein A., Assmann G.: Cell derived unesterified cholesterol is cycled betweeen high density lipoproteins and low density lipoproteins for its effective esterification. Arteriosclerosis Thromb. 1993; in press.
Assmann G., Schmitz G., Funke H., von Eckardstein A.: Apolipoprotein A-I and HDL Deficiency. Curr. Opin. Lipidol. 1990;1:110–115.
Assmann G., von Eckardstein A. and Funke H.: Lecithinxholesterol acyltransferase deficiency and fish eye disease. Curr. Opin. Lipidol 1991;2:110–117.
Assmann G., von Eckardstein A., Funke H.: The role of Apolipoprotein mutants in HDL metabolism. in Rosseneu, M.Y. (ed.): Structure and function of apolipoproteins. CRC Reviews in Biochemistry, CRC Press, Boca Raton, 1992; pp 85–121.
Brown M.L., Hesler C. and Tall A.R.: Lecithin:cholesterol Aclytransferase and cholestery ester transfer protein. Curr. Opin. Lipidol. 1991;1:123–127.
Breslow J.L.: Familial Disorders of High Density Lipoprotein Metabolism. in Scriver, C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services. New York. 1989; pp 1251–1266.
Norum K.R., Gjone E. and Glomset J.A.: Familial lecithin:cholesterol acyltransferase deficiency including fish-eye disease. in Scriver C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services, New York, 1989; pp 1181–1194.
Assmann G., Schmitz G. and Brewer H.B.: Familial High Density Lipoprotein Deficiency:Tangier Disease, in Scriver C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services. New York. 1989; pp 1267–1282.
Swenson T.L.: Transfer proteins in reverse cholesterol transport. Curr. Opin. Lipidol. 1992;3:67–74.
Patsch J.R., Prasad S., Gotto A.M.: Postprandial lipemia: — key for the conversion of high density lipoproteins2 into high density lipoproteins3 by hepatic lipase. J. Clin. Invest. 1984;74:2017–2023.
Patsch J.R., Karlin J.B., Cott L.W., Smith L.C., Gotto A.M.: Inverse relationship betweeen blood levels of high density lipoprotein subtraction — and magnitude of postprandial lipemia. Proc. Natl. Acad. Sci. USA 1983;80:1449–1453.
Patsch J.R., Prasad S., Gotto A.M., Patsch W.: High density lipoproteins2: reletionship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J. Clin. Invest. 1987;30:341–347.
Patsch J.R., Miesenbock G., Hopferwieser T., Muhlberger V., Kanapp E., Dunn J.K., Gotto A.M., Patsch W.: The relationship of triglyceride metabolism and coronary artery disease: Studies in the postprandial state. Arteriosclerosis Thromb. 1992; 12.
Blankenhorn D.H., Alaupovic P., Wickham E., Chin H.P., Azen S.P.: Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts. Circulation 1990;81:470–476.
Nachman R.L.: Thrombosis and atherogenesis: molecular connections. Blood 1992;79:1897–1906.
Kuusi T., Ehnholm C, Viikari J., Harkonen R., Vartiainen E., Puska P;, Taskinen M.R.: Postheparin plasma lipoprotein and hepatic lipase determinants of hypo-and hyper-alphalipoproteinemia. J. Lipid Res. 1989;30:117–1126.
Babirak S.P., Brown G., Brunzell J.D.: Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arteriosclerosis Thromb. 1992; 12:1176–1183.
Laloue J.M., Wilson D.E., Iverius P.H.: Lipoprotein lipase and hepatic triglyceride lipase: molecular and genetic aspects. Curr. Opin. Lipidol. 1992;3:86–95.
Laws A., King A.C., Haskell W.L., Reaven G.M.: Relation of fasting plasma insulin concentration to high density lipoprotein cholesterol and triglycerides in men. Arteriosclerosis Thromb 1991, 11:1636–1642.
Laakso M., Sarlund, Mykkanen L.: Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis 1990;10:223–231.
Williams R.R., Hunt S.C., Hopkins P.N., Stults B.M., Wu L.L., Hasstedt S.J., Barlow G.K., Stephenson S.H., Lalouel J.M., Kuida H.: Familial dyslipidemic hypertension. — AMA 1988;259 3579–3586.
Reaven G.M.: Role of insulin resistance in human disease. Diabetes 1988;37:1595–1607.
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von Eckardstein, A., Assmann, G., Schulte, H. (1993). Relationship of HDL Cholesterol to Incidence of Atherosclerotic Coronary Heart Disease: The Procam Experience. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_42
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DOI: https://doi.org/10.1007/978-94-011-1703-6_42
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