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Relationship of HDL Cholesterol to Incidence of Atherosclerotic Coronary Heart Disease: The Procam Experience

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Drugs Affecting Lipid Metabolism

Part of the book series: Medical Science Symposia Series ((MSSS,volume 2))

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Abstract

The incidence of atherosclerotic coronary heart disease (CHD) was assessed in 4559 male partecipants of the Prospective Cardiovascular Munster (PROCAM) study, aged 40 to 64 years, over — 6 year follow-up period. In this time, 186 study partecipants developed atherosclerotic CHD (134 definite nonfatal myocardial infarctions and 52 definite atherosclerotic CHD deaths including 21 sudden cardiac deaths and 31 fatal myocardial infarctions). Univariate analysis revealed — significant association between the incidence of atherosclerotic CHD, and high density lipoprotein (HDL) cholesterol (p<0.001), which remained after adjustment for other risk factors.

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References

  1. NIH Consensus Conference, Washington February 1992.

    Google Scholar 

  2. Assmann G., Oberwittler W., Schulte H., Schriewer H., Funke H., Epping P.H., Hauss W.H.: Pradiktion und Fruherkennung der koronaren Herzkrankheit. Internist 1980; 21:446–459.

    PubMed  CAS  Google Scholar 

  3. Friedewald W.T., Levy J., Fredrickson D.S.: Estimation of the concentration of low-density-lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972;18:499–509.

    PubMed  CAS  Google Scholar 

  4. Assmann G., Schulte H.: PROCAM Trial. Panscientia publishing house, Hedingen-Zurich 1986.

    Google Scholar 

  5. Assmann G., Schulte H.: Relation of High Density Lipoprotein Cholesterol and Triglycerides to Incidence of Atherosclerotic Coronary Artery Disease (The PROCAM Experience). Am. J. Cardiol. 1992; 70:733–737.

    Article  PubMed  CAS  Google Scholar 

  6. Nie N.H.: SPSSX User’s Guide. McGraw-Hill, New York. 1983.

    Google Scholar 

  7. Ray A.A.: SAS User’s Guide: Basics. Cary, NC, SAS Institute, 1982.

    Google Scholar 

  8. Assmann G., Schulte H.: Results and Conclusions of the Prospective Cardiovascular Munster (PROCAM) Study. In: Assmann G. (ed.) Lipid Metabolism Disorders and Coronary Heart Disease (completely revised second edition). MMV Medizin Verlag, Munchen, 1993 (in press).

    Google Scholar 

  9. Gordon T., Castelli W.P., Hjortland M.C., Kannel W.B., Dawber T.R.: High-density lipoprotein as — protective factor against coronary heart disease: The Framingham Study. Am. J. Med. 1977;62:707–714.

    Article  PubMed  CAS  Google Scholar 

  10. Jacobs D.R. (for Lipid Research Clinics Follow-up Study): High density lipoprotein cholesterol and coronary heart disease cardiovascular disease and all-cause mortality, abstract. Circulation 1985;72(suppl III): 185.

    Google Scholar 

  11. Watkins L.O., Neaton J.D., Phillips A.N. (for the MRFIT Research Group): High-density lipoprotein cholesterol and coronary heart disease incidence in black and white MRFIT usual care men. Am. J. Cardiol. 1986;57:538–545.

    Article  PubMed  CAS  Google Scholar 

  12. Miller N.E., Forde O.H., Thelle D.S., Mjos O.D. The Tromso Heart Study: High-density lipoprotein as — protective factor against coronary heart disease: — prospective case-control study. Lancet 1977;i:965–970.

    Article  Google Scholar 

  13. Goldbourt U., Medalie J.H.: High-density lipoprotein cholesterol and incidence of coronary heart disease: The Israeli Ischaemic Heart Disease Study. Am. J. Epidemiol. 1979;109:296–308.

    PubMed  CAS  Google Scholar 

  14. Enger S.C., Hjermann I., Foss O.P., Helgeland A., Holme I., Leren P., Norum K.R.: High-density lipoprotein cholesterol and myocardial infarction or sudden coronary death: — prospective case-control study in middle-aged men of the Oslo study. Artery 1979;5:170–181.

    PubMed  CAS  Google Scholar 

  15. Shestov D.B. Results of four years of follow-up of USSR populations. In USA-USSR First Lipoprotein Symposium, Bethesda, 1982. Us Department of Health and Human Services, National Institutes of Health, Publication (NIH) 83-1966, 391-407.

    Google Scholar 

  16. Keys A., Karvonen M.J., Punsar S., Menotti A., Fidanza F., Farchi G.: HDL serum cholesterol and 24-year mortality of men in Finland. Int. J. Epidemiol. 1984;13:428–435.

    Article  PubMed  CAS  Google Scholar 

  17. Pocock S.J., Shaper A.G., Phillips A.N., Whitehead T.P.: High density lipoprotein cholesterol is not — major risk factor for ischemic heart disease in British men. Br. Med. J. 1986;292:515–519.

    Article  CAS  Google Scholar 

  18. Frick H.M., Elo O., Haapa K., Heinonen O.P., Heinsalmi P., Helo P., Huttunen J.K., Kaitaniemi P., Koskinen P., Maenpaa H., Malkonen M., Manttari M., Norola S., Pasternack A., Pikkarainen J., Romo M., Sjoblom T., Nikkila E.A.: The Helsinki Heart Study-primary prevention trial with gemfibrozil in middle aged men with dyslipidaemia. Safety of treatment, Changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 1987; 317:1237–1245.

    Article  PubMed  CAS  Google Scholar 

  19. Manninen V., Huttunen J.K., Heinonen O.P., Tenkanen L., Frick M.H.: Relation between baseline lipid and lipoprotein values and the incidence of coronary heart disease in the Helsinki Heart Study. Am. J. Cardiol. 1989; 63:42H–47H.

    Article  PubMed  CAS  Google Scholar 

  20. Manninen V., Elo O., Frick M.H., Haapa K., Heinonen O.P., Heinsalmi P., Helo P., Huttunen J.K., Kaitaniemi P., Koskinen P., Maenpaa H., Malkonen M., Manttari M., Norola S., Pasternack A., Pikkarainen J., Romo M., Sjoblom T., Nikkila E.A.: Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. J. AMA 1988; 260:641–651.

    CAS  Google Scholar 

  21. Huttunen J.K., Manninen V., Manttari M., Koskinen P., Romo M., Tenkanen L., Heinonen O.P., Frick M.H.: The Helsinki Heart Study: Central Findings and Clinical Implications. Annals of Medicine 1991; 23: 155–159.

    Article  PubMed  CAS  Google Scholar 

  22. Hunt S.C., Hasstedt S.J., Kuida H., Stults B.M., Hopkins P.N. and Wiliams R.R.: Genetic heritability and common environmental components of resting and stressed blood pressures, lipids and body mass index in Utah pedigrees and twins. Am. J. Epidemiology 1989;129:625–638.

    CAS  Google Scholar 

  23. Christian J.G., Carmelli D., Castelli W.P., Fabsitz R., Grim C.E., Meaney F.J., Norton J.A., Reed T., Williams C.J. and Wood P.D.: High Density Lipoprotein Cholesterol. — 16 year longitudinal study in aging male twins. Arteriosclerosis 1990;10:1020–1027.

    Article  PubMed  CAS  Google Scholar 

  24. DeBacker G., Hulstaerdt F., DeMunck, Rosseneu M., Van Parijs L. and Dramaix M.: Serum lipids and apoproteins in students whose patients suffered prematurely form myocardial infarction. Am. Heart J. 1986; 112:478–484.

    Article  CAS  Google Scholar 

  25. Pometta D., Micheli H., Suenram A., Jornot C: HDL lipids in close relatives of coronary heart disease patients. Atherosclerosis 1979;34:419–429.

    Article  PubMed  CAS  Google Scholar 

  26. Glomset J.A.: The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 1968;9:155–163.

    PubMed  CAS  Google Scholar 

  27. Eisenberg S.: High Density Lipoprotein Metabolism. J. Lipid Res. 1984;25:1017–1058.

    PubMed  CAS  Google Scholar 

  28. Tall A.R.: Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J. Clin. Invest. 1990;86:379–384.

    Article  PubMed  CAS  Google Scholar 

  29. Schmitz G., Bruning T., Williamson E. and Nowick G.: The role of reverse cholesterol transport and its disturbances in Tangier disease and HDL deficiency with xanthomas. Eur. Heart. J. 1990; 11(Suppl. E): 197–207.

    Article  PubMed  CAS  Google Scholar 

  30. Johnson W.J., Mahlberg F.H., Rothblat G.H., Phillips M.C.: Cholesterol transport between cells and high density lipoproteins. Biochim. Biophys. Acta 1991;1085:273–298.

    Article  PubMed  CAS  Google Scholar 

  31. Oram J.: Cholesterol traffiking in cells. Curr. Opin. Lipidol. 1990;1:416–421.

    Article  Google Scholar 

  32. Ailhaud G.: Cellular signal transductans: — new role for HDL. Curr. Opin. Lipidol. 1992;2:222–226.

    Article  Google Scholar 

  33. Castro G.R. and Fielding C.J.: Early incorporation of cell-derived cholesterol into pre-P-migrating high density lipoprotein. Biochemistry 1988;27:25–29.

    Article  PubMed  CAS  Google Scholar 

  34. Huang Y., von Eckardstein A., Assmann G.: Cell derived unesterified cholesterol is cycled betweeen high density lipoproteins and low density lipoproteins for its effective esterification. Arteriosclerosis Thromb. 1993; in press.

    Google Scholar 

  35. Assmann G., Schmitz G., Funke H., von Eckardstein A.: Apolipoprotein A-I and HDL Deficiency. Curr. Opin. Lipidol. 1990;1:110–115.

    Article  Google Scholar 

  36. Assmann G., von Eckardstein A. and Funke H.: Lecithinxholesterol acyltransferase deficiency and fish eye disease. Curr. Opin. Lipidol 1991;2:110–117.

    Article  CAS  Google Scholar 

  37. Assmann G., von Eckardstein A., Funke H.: The role of Apolipoprotein mutants in HDL metabolism. in Rosseneu, M.Y. (ed.): Structure and function of apolipoproteins. CRC Reviews in Biochemistry, CRC Press, Boca Raton, 1992; pp 85–121.

    Google Scholar 

  38. Brown M.L., Hesler C. and Tall A.R.: Lecithin:cholesterol Aclytransferase and cholestery ester transfer protein. Curr. Opin. Lipidol. 1991;1:123–127.

    Google Scholar 

  39. Breslow J.L.: Familial Disorders of High Density Lipoprotein Metabolism. in Scriver, C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services. New York. 1989; pp 1251–1266.

    Google Scholar 

  40. Norum K.R., Gjone E. and Glomset J.A.: Familial lecithin:cholesterol acyltransferase deficiency including fish-eye disease. in Scriver C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services, New York, 1989; pp 1181–1194.

    Google Scholar 

  41. Assmann G., Schmitz G. and Brewer H.B.: Familial High Density Lipoprotein Deficiency:Tangier Disease, in Scriver C.R., Beaudet A.L., Sly W.S. and Valle D. (eds.): The Metabolic Basis of Inherited Disease. 6th edition. McGraw-Hill Information Services. New York. 1989; pp 1267–1282.

    Google Scholar 

  42. Swenson T.L.: Transfer proteins in reverse cholesterol transport. Curr. Opin. Lipidol. 1992;3:67–74.

    Article  CAS  Google Scholar 

  43. Patsch J.R., Prasad S., Gotto A.M.: Postprandial lipemia: — key for the conversion of high density lipoproteins2 into high density lipoproteins3 by hepatic lipase. J. Clin. Invest. 1984;74:2017–2023.

    Article  PubMed  CAS  Google Scholar 

  44. Patsch J.R., Karlin J.B., Cott L.W., Smith L.C., Gotto A.M.: Inverse relationship betweeen blood levels of high density lipoprotein subtraction — and magnitude of postprandial lipemia. Proc. Natl. Acad. Sci. USA 1983;80:1449–1453.

    Article  PubMed  CAS  Google Scholar 

  45. Patsch J.R., Prasad S., Gotto A.M., Patsch W.: High density lipoproteins2: reletionship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J. Clin. Invest. 1987;30:341–347.

    Article  Google Scholar 

  46. Patsch J.R., Miesenbock G., Hopferwieser T., Muhlberger V., Kanapp E., Dunn J.K., Gotto A.M., Patsch W.: The relationship of triglyceride metabolism and coronary artery disease: Studies in the postprandial state. Arteriosclerosis Thromb. 1992; 12.

    Google Scholar 

  47. Blankenhorn D.H., Alaupovic P., Wickham E., Chin H.P., Azen S.P.: Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts. Circulation 1990;81:470–476.

    Article  PubMed  CAS  Google Scholar 

  48. Nachman R.L.: Thrombosis and atherogenesis: molecular connections. Blood 1992;79:1897–1906.

    PubMed  CAS  Google Scholar 

  49. Kuusi T., Ehnholm C, Viikari J., Harkonen R., Vartiainen E., Puska P;, Taskinen M.R.: Postheparin plasma lipoprotein and hepatic lipase determinants of hypo-and hyper-alphalipoproteinemia. J. Lipid Res. 1989;30:117–1126.

    Google Scholar 

  50. Babirak S.P., Brown G., Brunzell J.D.: Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arteriosclerosis Thromb. 1992; 12:1176–1183.

    Article  CAS  Google Scholar 

  51. Laloue J.M., Wilson D.E., Iverius P.H.: Lipoprotein lipase and hepatic triglyceride lipase: molecular and genetic aspects. Curr. Opin. Lipidol. 1992;3:86–95.

    Article  Google Scholar 

  52. Laws A., King A.C., Haskell W.L., Reaven G.M.: Relation of fasting plasma insulin concentration to high density lipoprotein cholesterol and triglycerides in men. Arteriosclerosis Thromb 1991, 11:1636–1642.

    Article  CAS  Google Scholar 

  53. Laakso M., Sarlund, Mykkanen L.: Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis 1990;10:223–231.

    Article  PubMed  CAS  Google Scholar 

  54. Williams R.R., Hunt S.C., Hopkins P.N., Stults B.M., Wu L.L., Hasstedt S.J., Barlow G.K., Stephenson S.H., Lalouel J.M., Kuida H.: Familial dyslipidemic hypertension. — AMA 1988;259 3579–3586.

    CAS  Google Scholar 

  55. Reaven G.M.: Role of insulin resistance in human disease. Diabetes 1988;37:1595–1607.

    Article  PubMed  CAS  Google Scholar 

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von Eckardstein, A., Assmann, G., Schulte, H. (1993). Relationship of HDL Cholesterol to Incidence of Atherosclerotic Coronary Heart Disease: The Procam Experience. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_42

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  • DOI: https://doi.org/10.1007/978-94-011-1703-6_42

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4746-3

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