Abstract
Lowering cholesterol by the treatment with LDL-apheresis using dextran sulfate-cellulose beads affinity column resulted in — regression of coronary atherosclerosis in 38% of the patients including — cases of homozygous familial hypercholesterolemia (FH), 25 cases of heterozygous FH, and — other cases of mild to severe hypercholesterolemia. In heterozygous FH and others, regression took place in — out of 15 cases where plasma cholesterol was reduced more than 120 mg/dl by apheresis treatment, but in only — out of 14 cases, where cholesterol reduction was less than 120 mg/dl. Regression was also observed in — out of — cases of homozygous FH and there was no case with progression in this group.
Plasma cholesterol levels are not available in 1 of 15 patients with unchanged segments.
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© 1993 Springer Science+Business Media Dordrecht
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Goto, Y. et al. (1993). Regression of Coronary Atherosclerosis by LDL-Apheresis. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_36
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DOI: https://doi.org/10.1007/978-94-011-1703-6_36
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