Abstract
Vitamin E, a chain-breaking antioxidant, is the major lipid soluble antioxidant in the plasma. Studies in humans of the absorption and incorporation of vitamin E into lipoproteins have been carried out using RRR- and SRR- α-tocopherols and RRR-?-tocopherol labeled with different amounts of deuterium. We have investigated normal subjects and patients with abetalipoproteinemia, lipoprotein lipase deficiency, abnormal apolipoprotein B-100 synthesis, and familial isolated vitamin E deficiency. We found that all three labeled tocopherols are absorbed equally and are secreted in chylomicrons. In the liver RRR- α-tocopherol is preferentially incorporated into nascent very low density lipoprotein (VLDL), presumably by a hepatic tocopherol binding protein. Therefore, ?- and SRR- α-tocopherols do not re-appear in the plasma to the same extent as RRR- α-tocopherol. Thus, chylomicrons function to transport various dietary tocopherols from the intestine, while VLDL preferentially transport RRR-α-tocopherol into the plasma, where mechanisms of lipoprotein metabolism result in the transfer of α-tocopherol to the other lipoproteins.
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Traber, M.G., Kayden, H.J. (1993). Vitamin E—Absorption, Transport in Lipoproteins, Delivery to Tissues and Antioxidant Activity. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_23
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DOI: https://doi.org/10.1007/978-94-011-1703-6_23
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