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High Density Lipoproteins: Function in Reverse Cholesterol Transport and Maintenance of Cellular Integrity

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Drugs Affecting Lipid Metabolism

Part of the book series: Medical Science Symposia Series ((MSSS,volume 2))

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Abstract

High density lipoproteins (HDL) have long been known to play an important role in reverse cholesterol transport. This has served as an explanation for the epidemiologic observation that HDL-cholesterol and apolipoprotein (apo) A-I are inversely correlated with the risk for coronary artery disease. More recent data indicate that HDL is involved in several other mechnisms such as coagulation, immunomodulation, cell proliferation, and detoxification. It appears that specific subclasses of HDL may serve different ructions. One potentially important discovery is the presence of clusterin in a specific HDL-fraction. Clusterin, which is also known as complement lysis inhibitor or apoJ, has been shown to be associated with slow migrating HDL in isotachophoresis. Since it has a high affinity to damaged cell membranes, it may play an important role in targeting of HDL to sites of tissue damage and repair. Studies regarding the function of clusterin containing HDL particles are likely to permit new insights into the antiatherogenic mechanisms related to HDL. Of particular importance will be the interaction of these particles with the cells of the vessel wall. To this end more refined methods to isolate functional HDL subclasses are necessary.

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Authors
  1. K. J. Lackner
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  2. G. Schmitz
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Università di Milano, Via Balzaretti 9, I-20133, Milano, Italy

    A. L. Catapano  & Rodolfo Paoletti (Direttore) &  (Direttore)

  2. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    A. M. Gotto Jr. (Chairman) (Chairman)

  3. Department of Medicine, The Methodist Hospital, 6565 Fannin M.S. A601, Houston, TX, 77030-2797, USA

    Louis C. Smith (Professor of Experimental Medicine) (Professor of Experimental Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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Lackner, K.J., Schmitz, G. (1993). High Density Lipoproteins: Function in Reverse Cholesterol Transport and Maintenance of Cellular Integrity. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_17

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  • DOI: https://doi.org/10.1007/978-94-011-1703-6_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4746-3

  • Online ISBN: 978-94-011-1703-6

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