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Modulation of Triglyceride Metabolism by Diet and Drugs

  • Chapter
Drugs Affecting Lipid Metabolism

Part of the book series: Medical Science Symposia Series ((MSSS,volume 2))

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Abstract

Lipoprotein lipase is a key enzyme in the mobilization of fat from triglyceride-rich particles in human plasma. The composition of very low density lipoproteins (VLDL) and chylomicrons, which are secreted by the liver and the intestine, respectively, are important determinants of the composition, structure and catabolism of high (HDL) and low density lipoproteins (LDL). HDL and LDL communicate with triglyceride-rich lipoproteins through the action of cholesteryl ester transfer protein (CETP) which exchanges the triglycerides of the latter for the cholesteryl esters of the former. Therefore, the amounts of triglyceride in VLDL and chylomicrons are important determinants of the triglyceride content and the metabolic fates of HDL and LDL. Under fasting conditions the major donor of triglycerides to LDL and HDL are the VLDL. Therefore, factors that affect fasting triglycerides are likely to have an effect on metabolism of all lipoproteins including the chylomicrons.

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Literature Cited

  1. Dixon JL, Furukawa S, and Ginsberg HN. A Biol Chem 1991; 266:5080.

    PubMed  CAS  Google Scholar 

  2. Erickson SK, and Fielding PE. A Lipid Res 1986; 27:875.

    PubMed  CAS  Google Scholar 

  3. Stirling C, McAleer M, Reckless HPD, Campbell RR, Mundy D, Betteridge DJ, and Foster K. Chemical Science 1985; 68:83.

    CAS  Google Scholar 

  4. Goh EH and Heimberg M. Biochem. Bilphys. Res. Commun. 1973; 55:382–388.

    Article  CAS  Google Scholar 

  5. Soler-Argilaga C, Wilcox HG and Heimberg M. A Lipid Res 1976; 17:139.

    PubMed  CAS  Google Scholar 

  6. Elkeles RS, Ashwell M, Priest R, and Dkurrant M. Proc Roy Soc Med 1976; 69(Supplement 2):98.

    PubMed  CAS  Google Scholar 

  7. Carlson LA. Proc Roy Soc Med 1976; 69 (Supplement 2): 101.

    PubMed  CAS  Google Scholar 

  8. Rifkind B. Metabolism 1966; 15:673.

    Article  PubMed  CAS  Google Scholar 

  9. Harris WS. A Lipid Res 1989; 30:785.

    PubMed  CAS  Google Scholar 

  10. Nestel PJ. Annu Rev Nutr 1990; 10:149.

    Article  PubMed  CAS  Google Scholar 

  11. Rustan AC, Nossen JO, Christiansen EN, and Drevon CA. A Lipid Res 1988; 29:1417.

    PubMed  CAS  Google Scholar 

  12. Wong SH and Marsh JB. Metabolism 37:1177.

    Google Scholar 

  13. Yamazaki RK, Shen T, and Schade GB. Biochim Biophys Acta 1987; 920:62.

    Article  PubMed  CAS  Google Scholar 

  14. Homan R, Grossman JE, and Pownall HJ. A Lipid Res 1991; 32:231–241.

    PubMed  CAS  Google Scholar 

  15. Yao, ZM, and Vance DE. A Biol Chem 1987; 263:2998.

    Google Scholar 

  16. Stacpoole PW, Alig J, Kilgore LL, Ayala CM, Herbert PN, Zech LA, and Fisher WR. 1988. Metabolism 37:944–951.

    Article  PubMed  CAS  Google Scholar 

  17. Tsai CE, Wooten JT, and Otto DA. Nutr Res 1989; 9:673.

    Article  Google Scholar 

  18. Baltzell JK, Wooten JT, and Otto DA. Lipids 1991; 26:289.

    Article  PubMed  CAS  Google Scholar 

  19. Bick D, Pao Q, and Pownall HJ (abstract) FASEB Journal 1992; 6:A370.

    Google Scholar 

  20. Hulsmann WC, Oerdemanus MC, and Jansen H. Biochim Biophys Acta 1980; 618:364–369.

    Article  PubMed  CAS  Google Scholar 

  21. Weintraub MS, Zechner R, Brown A, Eisenberg S, and Breslow JL. A Clin Invest 1988; 82:1884–1893.

    Article  PubMed  CAS  Google Scholar 

  22. Lieber, CS, and Pignon, J.-P. In: A Shepherd and JC Fruchart, eds. Human plasma lipoproteins: Chemistry, Physiology and Pathology. 1989:245–280.

    Google Scholar 

  23. Weintraub MS, Eisenberg S, and Breslow JL. A Clin Invest 1987; 79:1110.

    Article  PubMed  CAS  Google Scholar 

  24. Wilson, DE, Schreibman PH, Brewster AC, and Arky RA. A Lab Clin Med. 1970; 75:264–274.

    PubMed  CAS  Google Scholar 

  25. Chait A, Mancini M, February AW, and Lewis B. Lancet 1972; 2:62–64.

    Article  PubMed  CAS  Google Scholar 

  26. Jones DP, Perman ES, and Lieber CS. A Lab Clin Med 1965; 66:804–813.

    PubMed  CAS  Google Scholar 

  27. Crouse JR, Gerson CD, DeCarli LM, and Lieber CS. A Lipid Res 1968; 9:509–512.

    PubMed  CAS  Google Scholar 

  28. Abramson, EA, and Arky, RA. A Lab Clin Med 1968; 72:105–117.

    PubMed  CAS  Google Scholar 

  29. Frayn KN, Coppack SW, Walsh PE, Butterworth HC, Humphreys SM, and Pedrosa HC. Metabolism 1990; 39:958

    Article  PubMed  CAS  Google Scholar 

  30. Patsch JR, Karlin JV, Scott LW, Gotto AM Jr. Proc Natl Acad Sci USA 1983; 80:1449

    Article  PubMed  CAS  Google Scholar 

  31. Patsch JR, Hopferwieser Th, Muhlberger V, Knapp E, Braunsteiner H, Gotto AM, Dunn K, and Patsch W. Postprandial lipemia in patients with coronary artery disease. Arteriosclerosis 1990; 10:766a

    Google Scholar 

  32. Deckelbaum RJ, Granot E, Oschry Y, Rose L, and Eisenberg S. Arteriosclerosis 1984; 4:225.

    Article  PubMed  CAS  Google Scholar 

  33. Mann CJ, Yen FT, Grant AkMk, and Bihain BE. A Clin Invest 1991; 88:2059.

    Article  PubMed  CAS  Google Scholar 

  34. Austin MA. Arteriosclerosis and Thrombosis. 1991; 11:2–14.

    Article  PubMed  CAS  Google Scholar 

  35. Assman G, Gotto AM, and Paoletti R., eds. Report of an international committee for the Evaluation of hypertriglyceridemia as a vascular risk factor. Amer a Cardiol 1991; 681A

    Google Scholar 

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Authors
  1. Patricia Pace
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  2. Roger D. Knapp
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  3. Peter H. Jones
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  4. Henry J. Pownall
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  5. Antonio M. Gotto Jr.
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Università di Milano, Via Balzaretti 9, I-20133, Milano, Italy

    A. L. Catapano  & Rodolfo Paoletti (Direttore) &  (Direttore)

  2. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    A. M. Gotto Jr. (Chairman) (Chairman)

  3. Department of Medicine, The Methodist Hospital, 6565 Fannin M.S. A601, Houston, TX, 77030-2797, USA

    Louis C. Smith (Professor of Experimental Medicine) (Professor of Experimental Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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Pace, P., Knapp, R.D., Jones, P.H., Pownall, H.J., Gotto, A.M. (1993). Modulation of Triglyceride Metabolism by Diet and Drugs. In: Catapano, A.L., Gotto, A.M., Smith, L.C., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Medical Science Symposia Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1703-6_15

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  • DOI: https://doi.org/10.1007/978-94-011-1703-6_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4746-3

  • Online ISBN: 978-94-011-1703-6

  • eBook Packages: Springer Book Archive

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