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Autoantibodies to scleroderma-associated antigens

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Manual of Biological Markers of Disease

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Abstract

Speckled and nucleolar patterns of nuclear fluorescence using mouse liver as substrate were first reported in 60 percent of scleroderma patients by Rothfield and Rodnan in 1968 [1]. Since then the characteristics of the speckles have been defined and many of the autoantigens have been identified. The anti-centromere antibody (ACA) was identified when tissue culture cells in division instead of resting rodent liver or kidney were used as substrate in the indirect immunofluorescence assay [2]. ACA since then have been separated into specific antibodies directed against specific centromeric proteins (CENPs), i.e. anti-CENP-A, anti-CENP-B, and anti-CENP-C [3]. ACA along with anti-topoisomerase I are very specific for scleroderma/ CREST and are the major autoantibodies found in this group of diseases. The autoantibodies are easily detected by assays available in nearly all clinical laboratories. (see also Chapter A and Chapter B.5.2)

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Author information

Authors and Affiliations

  1. Department of Medicine MC-1310, The School of Medicine of the University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, 06032, USA

    Naomi F. Rothfield

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  1. Naomi F. Rothfield
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Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1996 Kluwer Academic Publishers

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Rothfield, N.F. (1996). Autoantibodies to scleroderma-associated antigens. In: van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1670-1_45

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  • DOI: https://doi.org/10.1007/978-94-011-1670-1_45

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-2219-1

  • Online ISBN: 978-94-011-1670-1

  • eBook Packages: Springer Book Archive

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