Skip to main content
SpringerLink
Log in

The PM/Scl antigens

  • Chapter
Manual of Biological Markers of Disease

  • 82 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

CTNE:

Calf thymus nuclear extract

PM/Scl:

Polymyositis-Scleroderma

ELISA:

Enzyme-linked immunosorbant assay

UTR:

Untranslated region

References

  1. Reichlin M & Mattioli M (1976) Description of a serological reaction characteristic of polymyositis. Clin Immunol Immunopathol 5: 12–20

    Article  PubMed  CAS  Google Scholar 

  2. Wolfe JF, Adelstein E & Sharp GC (1977) Antinuclear antibody with distinct specificity for polymyositis. J Clin Invest 59: 176–178

    Article  PubMed  CAS  Google Scholar 

  3. Bernstein RM, Bunn CC, Hughes GRV, Francoeur AM & Mathews MB (1984) Cellular protein and RNA antigens in autoimmune diseases. Mol Biol Med 2: 105–120

    PubMed  CAS  Google Scholar 

  4. Targoff IN & Reichlin M (1985) Nucleolar localization of the PM-Scl antigen. Arthritis Rheum 28: 226–230

    Article  PubMed  CAS  Google Scholar 

  5. Reimer G, Scheer U, Peters JM & Tan EM (1986) Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/ scleroderma overlap syndromes. J Immunol 137: 3802–3808

    PubMed  CAS  Google Scholar 

  6. Reimer G, Steen VD, Penning CA, Medsger TA & Tan EM (1988) Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum 31: 525–532

    Article  PubMed  CAS  Google Scholar 

  7. Gelpi C, Alguero A, Angeles Martinez M, Vidal S, Juarez C & Rodriguez-Sanchez JL (1990) Identification of protein components reactive with anti-PM/Scl autoantibodies. Clin Exp Immunol 81: 59–64

    Article  PubMed  CAS  Google Scholar 

  8. Kipins RJ, Craft J & Hardin JA (1990) The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. Arthritis Rheum 33: 1431–1437

    Article  Google Scholar 

  9. Alderuccio F, Chan EKL & Tan EM (1991) Molecular characterization of an autoantigen of PM-Scl in the Polymyositis/Scleroderma overlap syndrome: A unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. J Exp Med 173: 941–952

    Article  PubMed  CAS  Google Scholar 

  10. Blüthner M & Bautz FA (1992) Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein. J Exp Med 176: 973–980

    Article  PubMed  Google Scholar 

  11. Ge Q, Frank MB, O’Brien C & Targoff IN (1992) Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. J Clin Invest 90: 559–570

    Article  PubMed  CAS  Google Scholar 

  12. Bautz FA, Haidmann L & Genth E (1988) Nucleolar autoantibodies in patients with polymyositis-scleroderma overlap syndrome. Z Rheumatol 47: 314

    Google Scholar 

  13. Brendel V, Dohlman J, Blaisdel BE & Karlin S (1991) Very long charge runs in systemic lupus erythematosus-associated autoantigens. Proc Natl Acad Sci USA 88: 1536–1539

    Article  PubMed  CAS  Google Scholar 

  14. Tan EM (1989) Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44: 93–151

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Martin Blüthner

    Present address: W.M. Keck Autoimmune Disease Center, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Rd., LaJolla, Ca, 92037, USA

Authors and Affiliations

  1. Institute of Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 230, D-69120, Heidelberg, Germany

    Friedlinde A. Bautz

Authors
  1. Friedlinde A. Bautz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Blüthner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Bautz, F.A., Blüthner, M. (1996). The PM/Scl antigens. In: van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1670-1_31

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1670-1_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-2219-1

  • Online ISBN: 978-94-011-1670-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation