Abstract
Some quality control aspects of the preparation of [methyl-11C]- and [1-11C]-labelled methionine is examined. The oxidation of [11C]-labelled methionine to its corresponding [11C]-labelled sulphoxide and sulphone during synthesis, purification and in analytical samples is emphasized. Analytical procedures for determination of enantiomeric and radiochemical purity are also discussed.
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LĂ¥ngström B, Lundqvist H. The preparation of 11C-methyl iodide and its use in the synthesis of 11C-methyl-L-methionine. Int J Appl Radiat Isot 1976; 27: 357–363.
Comar D, Cartron J-C, Maziere M, Marazano C. Labelling and metabolism of methionine-methyl-11C. Eur J Nucl Med 1976; 1: 11–14.
Berger G, Maziere M, Knipper R, Prenant C, Comar D. Automated synthesis of 11C-labelled radiopharmaceuticals: imipramine, chlorpromazine, nicotine and methionine. Int J Appl Radiat Isot 1979; 30: 393–399.
LĂ¥ngström B, Antoni G, Gullberg P, Halldin C, Malmborg P, NĂ¥gren K, Rimland A, Svärd H. Synthesis of L- and D-[methyl-11C]methionine. J Nucl Med 1987; 28: 1037–40.
Meyer G-J, Osterholz A, Hundeshagen H. Routine quality control of 11C-labelled radiopharmaceuticals by high pressure liquid chromatography. J Radioanal Chem 1983; 80: 229–235.
Meyer G-J, Coenen HH, Waters SL, LĂ¥ngström B, Cantineau R, Strijckmans K, Vaalburg W, Halldin C, Crouzel C, Mazière M. Quality assurance and quality control of short-lived radiopharmaceuticals. EEC report (in press).
Bolster JM, Vaalburg W, Elsinga PH, Wynberg H, Woldring MG. Synthesis of DL[1-11C]methionine. Appl Radiat Isot 1986; 37: 1069–1070.
Bolster JM, Vaalburg W, Elsinga PH, Ishiwata K, Vissering H, Woldring MG. The preparation of 11C-carboxylic labelled L-methionine for measuring protein synthesis rates. J Labelled Compd Radiopharm 1986; 23: 1081–1082.
Johnström P, Ehrin E, Stone-Elander S, Nilsson JLG. Synthesis of 11C-labelled D-and L-methionine for positron emission tomography. Investigation of the enantiomeric purity of the products. Acta Pharm Suec 1984; 21: 189–194.
Ishiwata K, Ido T, Vaalburg W. Increased amounts of D-enantiomer dependent on alkaline concentration in the synthesis of L-[methyl-11C]methionine. Appl Radiat Isot 1988; 39: 311–314.
Lundqvist H, LĂ¥ngström B, Malmqvist M. Determination of enantiomeric purity in biogenic 11C-labelled amino acids by aminoacylation of tRNA. J Radioanal Nucl Chem 1985; 89: 79–87.
NĂ¥gren K, LĂ¥ngström B. Synthesis of D/L- and L-Se-[methyl-11C]selenomethionine. J Labelled Compd Radiopharm 1988; 25: 133–139.
Bodanszky M. Principles of peptide synthesis. Berlin: Springer-Verlag, 1984: 146–148.
Janssen WPA, van Nispen JW, Jansen JFGA, Wiegman T, Paans AMJ, de Wied D, Woldring MG, Vaalburg W. Rapid conversion of a homocysteine-containing peptide into its corresponding 11CH3-labeled methionine sulfone analogue. PET experiments with H-[S-CH3]Met(O2)-Glu-His-Phe-D-Lys-Phe-OH. J Labelled Compd Radiopharm 1989; 26: 248–250.
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© 1993 Springer Science+Business Media Dordrecht
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NĂ¥gren, K. (1993). Quality Control Aspects in the Preparation of [11C]-Methionine. In: Mazoyer, B.M., Heiss, W.D., Comar, D. (eds) PET Studies on Amino Acid Metabolism and Protein Synthesis. Developments in Nuclear Medicine, vol 23. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1620-6_6
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DOI: https://doi.org/10.1007/978-94-011-1620-6_6
Publisher Name: Springer, Dordrecht
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