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Utilization of Amino Acid Transport Rates for the Differential Diagnosis of Brain Tumors

  • G.-J. Meyer
  • W. Burchert
  • K.-F. Gratz
  • H. Hundeshagen
Part of the Developments in Nuclear Medicine book series (DNUM, volume 23)

Abstract

Tumor growth is associated with the increase of tissue mass, a large fraction of which are protein containing structures. Since these are built up from amino acids it can be assumed that these building blocks accumulate in tumorous tissue to a larger extent, than in the surrounding tissue.

Keywords

Positron Emission Tomography Brain Tumor Glucose Utilization Amino Acid Uptake Blood Tumor Barrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ericson K, Bergström M, Eriksson L, Hatam A, Greitz T, Soederström CE, Widen L. Positron emission tomography with 68Ga-EDTA compared with transmission computedtomography in the evaluation of brain infarcts. Acta Radiol. 22, 385–389, 1981Google Scholar
  2. 2.
    Bergström M, Collins VP, Ehrin E, Ericson K, Eriksson L, Greitz T, Halldin C, Holst H v, Langström B, Lilja A, Lundquist H, Nagren K. Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using 68Ga-EDTA, 11C-Glucose, and 11C-Methionine. J. Comput. Assist. Tomogr. 7, 1062–1066, 1983PubMedCrossRefGoogle Scholar
  3. 3.
    Mosskin M, von Holst H, Ericson K, Noren G. The blood tumor barrier in intracranial tumors studied with X-ray computed tomography and positron emission tomography using 68-Ga EDTA. Neuroradiol. 28, 259, 1986CrossRefGoogle Scholar
  4. 4.
    Ericson, K., Lilja A, Bergström M., Collins VP., Eriksson, L., Ehrin E., v.Holst, H., Lundqvist H., Langström B., Mosskin, M. Positron emission tomography with 11C-methyl-L-methionine, 11C-D-glucose, and 68-Ga-EDTA in supratentorial tumors. J. Comput. Assist. Tomography 9, 683–689, 1985CrossRefGoogle Scholar
  5. 5.
    Mosskin M, Ericson K, Hindmarsh T, von Holst H, Collins VP, Bergström M, Eriksson L, Johnström P. Positron emission tomography compared with MRI and CT in supratentorial gliomas using multiple stereotactic biopsies as reference. Acta Radiologica 30, 225–323, 1989PubMedCrossRefGoogle Scholar
  6. 6.
    Lilja A, Bergstrom K, Hartvig P, Spännare B, Halldin C, Lundquist H, Langstrom B Dynamic Study of Supratentorial Gliomas with L-methyl-11-C-Methionine and Positron Emission Tomography. Amer. J. Neuro. Radiol. 6, 505–514 [ 1985 ]Google Scholar
  7. 7.
    Lilja A, Lundqvist H, Olsson Y, Spännare B, Gullberg P, Langström B. Positron emission tomography and computed tomography in differential diagnosis between recurrent or residual glioma and treatment induced brain lesions. Acta Radiol. 30, 121–128, 1989PubMedCrossRefGoogle Scholar
  8. 8.
    Mosskin M, von Holst H, Bergstrom M, Collins VP,Eriksson L, Johnström P, Noren G. Positron emission tomography with 11C-methionine and X-ray computed tomography of intracranial tumors compared with histopathologic examination of multiple biopsies. Acta Radiol. 28, 673–681, 1987PubMedCrossRefGoogle Scholar
  9. 9.
    Mosskin M, Ericson K, Hindmarsh T, von Holst H, Collins VP, Bergstrom M, Eriksson L, Johnström P. Positron emission tomography compared with magnetic resonance imaging and computed tomography in supratentorial gliomas using multiple stereotactic biopsies as reference. Acta Radiol. 30, 225–232, 1989PubMedCrossRefGoogle Scholar
  10. 10.
    Bustany P, Sargent T, Saudubray JH Henry JF, Comar D. Regional human brain uptake and protein incorporation of 11C-L-Methionine studied in vivo with PET. J. Cerebr. Blood Flow Metabol. 1, 17–18, 1981Google Scholar
  11. 11.
    Bustany P, Chatel M, Derlon, JM, Darcel F, Sgouropoulos P, Soussaline F, Syrota A. Brain tumor protein synthesis and histological grades: A study by positron emis-sion tomography [PET] with 11C-L-Methionine. J. Neurooncol. 3, 397–404, 1986PubMedCrossRefGoogle Scholar
  12. 12.
    Meyer, G.J., Schober O, Gaab, MR, Dietz, H., Hundeshagen H. Multi parameter studies in brain tumors. In: Beckers C, Goffinet A, Bol A, Eds., Positron Emission Tomography in Clinical Research and Clinical Diagnosis. Kluwer Acad. Publ., Dordrecht,1989, pp 229–248Google Scholar
  13. 13.
    Schober O, Duden C, Meyer G.-J., Müller JA, Hundeshagen H. Non selective transport of [11C-methyl]-L-, and -D-methionine into a malignant glioma. Eur. J. Nucl. Med. 13, 103–105, 1987PubMedCrossRefGoogle Scholar
  14. 14.
    Meyer G.-J., Schober O., Hundeshagen H. Uptake of 11C-D- and L-methionine in brain tumors. Eur J. Nucl. Med. 10, 373–376, 1985PubMedGoogle Scholar
  15. 15.
    Schober O., Creutzig H., Meyer G.-J., Becker H., Schwarzrock R., Dietz H., Hundeshagen H. 11C-Methionin-PET, IMP-SPECT, CT und MRI bei Hirntumoren. Fortschr. Roentgenstr. 143, 133–136, 1985CrossRefGoogle Scholar
  16. 16.
    Schober O., Meyer G.-J., Stolke D., Hundeshagen H. Brain tumor imaging using 11C-labelled L-methionine and D-methionine. J. Nucl. Med. 26, 98–99, 1985PubMedGoogle Scholar
  17. 17.
    Schober O., Meyer G.-J., Gaab M.R., Müller J.A., Hundeshagen H. Grading of brain tumors by L-[11C]methionine PET. J. Nucl. Med. 27: 890–891, 1986Google Scholar
  18. 18.
    Schober O., Meyer G.-J., Duden C., Lauenstein L., Niggemann J., Müller J.-A., Gaab M.R., Becker H., Dietz H., Hundeshagen H. Die Aufnahme von Aminosäuren in Hirntumoren mit der Positronen-Emissionstomographie als Indikator für die Beurteilung von Stoffwechselaktivität und Malignität. Fortschr. Röntgenstr. 147, 503–509, 1987CrossRefGoogle Scholar
  19. 19.
    Schober O., Meyer G.-J., Gaab M.R., Dietz H., Hundeshagen H. Multi-Parameter Studies in Brain Tumors by PET. J. Nucl. Med. 29, 853 1988Google Scholar
  20. 20.
    O’Tuama LA., Guilarte TR, Douglass KH, Wagner Jr, HN, Wong, DF, Dannals R.F., Ravert, HT, Wilson AA, La France N.D., Bice AN, Links JM. Assesment of [11C] L-Methionine transport into the human brain. J. Cerebr. Blood Flow Metabol. 9, 341–345 1988CrossRefGoogle Scholar
  21. 21.
    O’Tuama LA, La France ND, Dannals RF, Douglass KH, Links JM, Bice AN, Williams JA, Villemagne V, Wagner Jr. HN. Quantitative imaging of neutral amino acid transport by human brain tumors. J. Cerebr. Blood Flow Metabol. 7, S517, 1987CrossRefGoogle Scholar
  22. 22.
    Mineura K, Sasajima T, Yoshitaka S, Kowada M, Shishido F, Uemura K. Early and accurate detection of primary cerebral glioma with interfibrillary growth using 11C-L-methionine positron emission tomography. J. Med. Imaging 3, 192–193, 1989Google Scholar
  23. 23.
    Hatazawa J, Ishiwata K, Itoh M, Kameyama M, Kubota K, Ido T, Matsuzawa, T,Yoshimoto T, Watanuki S, Seo S. Quantitative evaluation of [methyl-11C1-methionine uptake in tumor using positron emission tomography. J. Nucl. Med. 30, 1809–1813, 1989PubMedGoogle Scholar
  24. 24.
    Kameyama M, Shirane R, Itoh J, Sato K, Katakura R, Yoshimoto T, Hatazawa J, Itoh M, Seo S, Ido T. The accumulation of 11C-Methionine and histological grade in cerebral glioma studied with PET. CYRIC Annnual Report 1988, Cyclotron and Radioisotope Center Tohoku University, Sendai 1989, pp 228–237Google Scholar
  25. 25.
    Schober O., Meyer, G.-J., Klinische Anwendung der Positronen Emissions Torno-graphie. In: Handbuch der medizinischen Radiologie Band XV/1B, DietheIm L, Heuck F, Olsson O, Strnad F., Vieten H., Zuppinger A., Eds. Springer Verlag Berlin 1988 pp 315–469.Google Scholar
  26. 26.
    Eriksson L. personal communications, cf. also: Proc. Eur Symp. on Positron Emission Tomography in Cancer, Hammersmith Hospital, London 5.-6. July 1989Google Scholar
  27. 27.
    Bergstrom M, and Muhr C. personal communications. cf. also: Proc. Eur Symp. on Positron Emission Tomography in Cancer, Hammersmith Hospital, London 5.-6. July 1989Google Scholar
  28. 28.
    Fujiwara, T, Matsazuwa T, Kubota K, Abe Y, Itoh M, Fukuda H, Hatazawa J, Yoshioka S, Yamaguchi K, Ito K, Watanuki S, Takahashi T, Ishiwata K, Iwata R, Ido T. Relationship between histologic type of primary lung cancer and carbon -11-Lmethionine uptake with positron emission tomography. J. Nucl. Med. 30, 33–37, 1989PubMedGoogle Scholar
  29. 29.
    Mies G, Bodsch W, Paschen W, Hossmann KA. Experimental application of triple labeled quantitative autoradiography for measurement of cerebral blood flow, glucose metabolism and protein biosynthesis. In: Heiss WD, Phelps ME, Eds., Positron Emission Tomography of the Brain. Springer Berlin 1983, pp 19–28CrossRefGoogle Scholar
  30. 30.
    Kirikae M, Diksik M, Yamamoto YL. Quantitative measurements of regional glucose Utilization and rate of valin incorporation into proteins by double tracer auto-radiography in the rat brain tumor model. J. Cerebr. Blood Flow Metabol. 9, 87–95, 1989CrossRefGoogle Scholar
  31. 31.
    Abe Y, Matsuzawa T, Itoh M, Ishiwata K, Fujiwara T, Sato T, Yamaguchi K, Ido T. Regional coupling of blood flow and methionine uptake in an experimental tumor assessed with autoradiography. Eu. J. Nucl. Med. 14, 388–392, 1988Google Scholar
  32. 32.
    Meyer, G.J., Schober O, Gaab, MR, Dietz, H., Hundeshagen H. Multi parameter studies in brain tumors. In: Beckers C, Goffinet A, Bol A, Eds., Positron Emission Tomography in Clinical Research and Clinical Diagnosis. Kluwer Acad. Publ., Dordrecht,1989, pp 229–248Google Scholar
  33. 33.
    Kameyama M, Tsurumi Y, Shirane R, Katakura R, Suzuki J, Itoh M, Fukuda H, Matsuzawa T, Watanuki, S, Ido T. Multi parametric analysis of brain tumor with PET. J. Cereb. Blood Flow Metabol. 7, S466 [ 1987 ]Google Scholar
  34. 34.
    Yamamoto YL, Thompson CJ, Meyer E, Robertson SJ, Feindel W. Dynamic positron emission tomography for stud of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr. J. Comp. Assist. Tomogr. 1, 43–56, 1977CrossRefGoogle Scholar
  35. 35.
    Kapoulesas I, Alavi A, Alves WM, Gur RE, Weiss DW. Registration of Three-dimensional MR and PET Images of the human brain without Markers. Radio1. 181, 731–739, 1991Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • G.-J. Meyer
  • W. Burchert
  • K.-F. Gratz
  • H. Hundeshagen

There are no affiliations available

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